Fine specificity of the antibody response to Epstein-Barr nuclear antigen-2 and other Epstein-Barr virus proteins in patients with clinically isolated syndrome: A peptide microarray-based case-control study

2016 ◽  
Vol 297 ◽  
pp. 56-62 ◽  
Author(s):  
Ludwig Schlemm ◽  
René Markus Giess ◽  
Ludwig Rasche ◽  
Catherina Pfuhl ◽  
Katharina Wakonig ◽  
...  
Keyword(s):  
Antibody Response ◽  
Epstein Barr Virus ◽  
Case Control Study ◽  
Case Control ◽  
Clinically Isolated Syndrome ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr ◽  
Epstein Barr Nuclear Antigen ◽  
Control Study

scholarly journals Cytomegalovirus, Epstein–Barr virus and risk of breast cancer before age 40 years: a case–control study

2004 ◽  
Vol 90 (11) ◽  
pp. 2149-2152 ◽  
Author(s):  
A K Richardson ◽  
B Cox ◽  
M R E McCredie ◽  
G S Dite ◽  
J-H Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epstein Barr Virus ◽  
Case Control Study ◽  
Case Control ◽  
Barr Virus ◽  
Epstein Barr ◽  
Control Study

EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: a case-control study

2008 ◽  
Vol 14 (8) ◽  
pp. 1120-1122 ◽  
Author(s):  
P Sundström ◽  
L Nyström ◽  
E Jidell ◽  
G Hallmans
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Human Leukocyte ◽  
Case Control ◽  
Nuclear Antigen ◽  
Barr Virus ◽  
Epstein Barr ◽  
Control Study

Objectives and methods The interaction between the two best documented risk factors (human leukocyte antigen [HLA] class II [DRB1*1501 positivity] and Epstein-Barr virus [elevated Epstein-Barr nuclear antigen 1 (EBNA-1) antibody reactivity]) for multiple sclerosis (MS) was studied in a case-control study of biobank samples from 109 MS cases and 212 matched referents. Results Multivariate logistic regression analysis showed that both were statistically significant in both sexes. HLA DRB1*1501-positive referents had higher EBNA-1 reactivity than HLA-negative referents. Less EBNA-1 reactivity was required to increase the MS risk in HLA DRB1*1501-positives than in HLA-negatives. Conclusion We suggest that HLA DRB1*1501-positive individuals have an increased vulnerability to EBV-induced autoimmunity.

scholarly journals Detection of Epstein–Barr virus in different sources of materials from patients with oral lichen planus: a case–control study

2015 ◽  
Vol 69 (4) ◽  
pp. 358-363 ◽  
Author(s):  
Rúbia da Rocha Vieira ◽  
Lígia Lavezo Ferreira ◽  
Éder Ricardo Biasoli ◽  
Daniel Galera Bernabé ◽  
Cáris Maroni Nunes ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Epstein Barr Virus ◽  
Oral Lichen Planus ◽  
Case Control Study ◽  
Case Control ◽  
Barr Virus ◽  
Epstein Barr ◽  
Oral Lichen ◽  
Different Sources ◽  
Control Study

scholarly journals Molecular detection of Epstein-Barr virus in breast cancer among Sudanese female population: a case-control study

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1355
Author(s):  
Eiman S. Ahmed ◽  
Lubna S. Elnour ◽  
Emmanuel E. Siddig ◽  
Rowa Hassan
Keyword(s):  
Breast Cancer ◽  
Epstein Barr Virus ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Cancer Tissue ◽  
Female Population ◽  
Barr Virus ◽  
Epstein Barr ◽  
Control Study

Background: Breast cancer is the most common cancer in women worldwide and in Sudan. Breast cancer occurs due to a multifactorial process and infection with an oncogenic virus has been recently investigated as a possible risk factor for breast cancer. For nearly two decades, studies have incriminated Epstein-Barr virus (EBV) in the etiology of breast cancer. However, the results are unconvincing, and their interpretation has remained a matter of debate. The aim of this study was to detect EBV in breast cancer biopsies obtained from Sudanese female patients. Methods: A descriptive, hospital-based, case-control study, conducted at Faculty of Medical Laboratory Science, University of Khartoum, Khartoum, Sudan. Archival blocks were obtained from 115 patients with breast cancer and 115 controls during the period between November 2016 till March 2017. Results: Among 115 breast cancer tissue specimens, EBV DNA was identified in 42/115 (36.5 %) samples and was not identified in 73/115 (63.5 %) tissue samples. The highest frequency of EBV detection was among 41–60 year-olds (23/42, 54.7 %), followed by 21–40 year-olds (12/42, 28.5 %) and 61–80 year-olds (5/42, 11.9 %). In the control group, the majority were diagnosed with fibroadenoma (70.4%), followed by fibrocystic changes (10.4%) and lactating changes (0.9%). Conclusion: The data obtained in this study demonstrated that EBV was present in a high percentage of our study population; however, the exact role of EBV in Sudanese breast cancer needs to be studied more in depth.

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