Quinolone treatment associated with myoclonic seizure, electroencephalography ‘contribution: A cause or precursor

2017 ◽  
Vol 381 ◽  
pp. 335-336 ◽  
Author(s):  
A. Basma ◽  
I. Kamoun ◽  
H. Zouari ◽  
K. Masmoudi ◽  
C. Mhiri
Keyword(s):  
Myoclonic Seizure

scholarly journals The Impact of Potassium Channel Gene Polymorphisms on Antiepileptic Drug Responsiveness in Arab Patients with Epilepsy

2018 ◽  
Vol 8 (4) ◽  
pp. 37 ◽  
Author(s):  
Laith AL-Eitan ◽  
Islam Al-Dalalah ◽  
Afrah Elshammari ◽  
Wael Khreisat ◽  
Ayah Almasri
Keyword(s):  
Potassium Channel ◽  
Disease Susceptibility ◽  
Case Control ◽  
P Value ◽  
Myoclonic Seizure ◽  
Increased Risk ◽  
Epileptic Patients ◽  
Drug Responsiveness ◽  
The Impact ◽  
Increased Susceptibility

This study aims to investigate the effects of the three potassium channel genes KCNA1, KCNA2, and KCNV2 on increased susceptibility to epilepsy as well as on responsiveness to antiepileptic drugs (AEDs). The pharmacogenetic and case-control cohort (n = 595) consisted of 296 epileptic patients and 299 healthy individuals. Epileptic patients were recruited from the Pediatric Neurology clinic at the Queen Rania Al Abdullah Hospital (QRAH) in Amman, Jordan. A custom platform array search for genetic association in Jordanian-Arab epileptic patients was undertaken. The MassARRAY system (iPLEX GOLD) was used to genotype seven single nucleotide polymorphisms (SNPs) within three candidate genes (KCNA1, KCNA2, and KCNV2). Only one SNP in KCNA2, rs3887820, showed significant association with increased risk of susceptibility to generalized myoclonic seizure (p-value < 0.001). Notably, the rs112561866 polymorphism of the KCNA1 gene was non-polymorphic, but no significant association was found between the KCNA1 (rs2227910, rs112561866, and rs7974459) and KCNV2 (rs7029012, rs10967705, and rs10967728) polymorphisms and disease susceptibility or drug responsiveness among Jordanian patients. This study suggests that a significant association exists between the KCNA2 SNP rs3887820 and increased susceptibility to generalized myoclonic seizure. However, the present findings indicate that the KCNA1 and KCNV2 SNPs do not influence disease susceptibility and drug responsiveness in epileptic patients. Pharmacogenetic and case-control studies involving a multicenter and multiethnic approach are needed to confirm our results. To improve the efficacy and safety of epilepsy treatment, further studies are required to identify other genetic factors that contribute to susceptibility and treatment outcome.

Myoclonic Seizure in the Postanesthesia Care Unit After Thoracic Laminectomy

2002 ◽  
Vol 95 (3) ◽  
pp. 777-779 ◽  
Author(s):  
Su-Man Lin ◽  
Mei-Yung Tsou ◽  
Kwok-Hon Chan ◽  
Young-Chen Yin ◽  
Shih-Tai Hsin ◽  
...  
Keyword(s):  
Postanesthesia Care Unit ◽  
Myoclonic Seizure

scholarly journals Levetiracetam-associated aggravation of myoclonic seizure in children

Seizure ◽  
2012 ◽  
Vol 21 (10) ◽  
pp. 807-809 ◽  
Author(s):  
Yong-Hong Liu ◽  
Xiao-Li Wang ◽  
Yan-Chun Deng ◽  
Gang Zhao
Keyword(s):  
Myoclonic Seizure

scholarly journals Myoclonic Seizure Due to Brainstem Metastasis of the Gall Bladder Carcinoma

1970 ◽  
Vol 7 (1-2) ◽  
pp. 73-76
Author(s):  
Shunsaku Hirai ◽  
Yoshinosuke Fukuchi ◽  
Mitsunori Morimatsu ◽  
Hirofumi Sawada ◽  
Kazutoshi Okano ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Gall Bladder Carcinoma ◽  
Myoclonic Seizure

scholarly journals Predictors of Childhood Intractable Epilepsy- A Retrospective Study in A Tertiary Care Hospital

1970 ◽  
Vol 33 (1) ◽  
pp. 6-15
Author(s):  
AKM Moinuddin ◽  
MM Rahman ◽  
S Akhter ◽  
CA Kawser
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Intractable Epilepsy ◽  
Childhood Epilepsy ◽  
Care Hospital ◽  
Predictors Of Outcome ◽  
Myoclonic Seizure ◽  
One Year ◽  
Onset Group ◽  
Early Onset Group

Objective: To study the predictors of intractable childhood epilepsy and to comparethe predictors of outcome in early and late onset childhood epilepsy.Design: Retrospective study.Study place: Child Development and Neurology Unit in the Department of Paediatricsof Bangabandhu Sheikh Mujib Medical University (BSMMU).Study period: January 2004 to December 2005.Subjects: Children with epilepsy of 1 month to 15 years of age who attended theepilepsy clinic.Results: The predictors of outcome of childhood epilepsy were analyzed. Accordingto outcome there were two groups, well- controlled group (seizure free for more than 6months) and intractable epilepsy ( one or more seizures per month over a period of 6months). The predictors of early and late onset childhood epilepsy were also compared.Total 73 cases were studied. Out of them 38 patients had early onset epilepsy (lessthan one year) and 35 had late onset epilepsy (more than one year). Median age ofonset of early and late onset of childhood epilepsy group was 3.5 months and 60months respectively. Male and female ratio was 1.53:1 and 0.94:1 in early and lateonset group respectively. Major seizure type was tonic-clonic seizure in 57.9% and77.1% patients of early and late onset group respectively. In this study, 27 (77.1%)patients of late onset and 5(13.2%) patients of early onset group achieved seizureremission. Independent predictors of intractable childhood epilepsy were finally found.Conclusion: In this study symptomatic epilepsy, myoclonic seizure, initial highfrequency of seizure, infantile spasm, neonatal seizures and birth asphyxia weresignificantly higher among early onset group than in late onset group. Early onset ofseizure, myoclonic seizure, initial high frequency of seizure (≥1 seizure/day),symptomatic etiology, neonatal seizure and microcephaly were found independentpredictors of intractable epilepsy.Key words: Early onset; late onset; intractable seizures.DOI: 10.3329/bjch.v33i1.5669Bangladesh Journal of Child Health 2009; Vol.33(1): 6-15

Hmong Child With Myoclonic Seizure Disorder

2000 ◽  
Vol 15 (8) ◽  
pp. 563-563
Author(s):  
Jerome S. Haller
Keyword(s):  
Seizure Disorder ◽  
Myoclonic Seizure

scholarly journals EFFICACY OF TOPIRAMATE AS ADD-ON THERAPY IN TWO DIFFERENT TYPES OF PROGRESSIVE MYOCLONIC EPILEPSY

2013 ◽  
Vol 56 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Caner Feyzi Demir ◽  
Hasan Hüseyin Özdemir ◽  
Bülent Müngen
Keyword(s):  
Quality Of Life ◽  
Adjunctive Therapy ◽  
Marked Decrease ◽  
Myoclonic Epilepsy ◽  
Myoclonic Seizure ◽  
Lafora's Disease ◽  
Different Types ◽  
Alternative Agent ◽  
Progressive Myoclonic Epilepsy

The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora’s disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy.

scholarly journals Clinico-Radiological Spectrum of Neuronal Migrational Disorders: A Study of Paediatric Patients in the Western Region of Nepal

1970 ◽  
Vol 28 (1) ◽  
pp. 10-13
Author(s):  
PK Swain ◽  
MS Dhaliwal ◽  
A Thapalial ◽  
PK Tiwari
Keyword(s):  
Family History ◽  
Developmental Delay ◽  
Tertiary Care ◽  
Focal Seizure ◽  
Congenital Talipes Equinovarus ◽  
Myoclonic Seizure ◽  
Paediatric Hospital ◽  
Talipes Equinovarus ◽  
History Of ◽  
Neuro Imaging

Objective: This study was conducted in a tertiary care paediatric hospital to ascertain the spectrum of clinical and radiological features of Neuronal Migrational Disorders in children. The role of inheritance in Neuronal Migrational Disorders is under intense investigation. Studies on Neuronal Migrational Disorders (NMDs) in children from developing countries are lacking. Method: Retrospective analysis of records of diagnosed cases by neuroimaging as Neuronal Migrational Disorders in the Department of Paediatrics. Results: Eighteen Children (2days to 8years age) with different types of neuronal migrational disorder based on neuro-imaging were included. Observed anomalies included Lissencephaly (33.3%), Pachygyria (16.6%), Polymicrogyria (5.5%), Heterotopia (11.1%), Schizencephaly (22.2%) and Hemimegalencephaly (5.5%). Focal Seizure in 5 (27.7%) cases, Generalised Tonic Clonic Seizures in 3 (16.6%) and Myoclonic Seizure in 2 (11.1%) cases were the types of seizure present in 10 (55.5%) patients. Five patients presented with Quadriparesis, two with Hemiplegia and one with Congenital Talipes Equinovarus. All the eighteen patients had some degree of Cognitive Developmental Delay. Conclusion: Lissencephaly is the most common type of Neuronal Migrational Disorder followed by Schizencepahly. Focal Seizure and Quadriparesis were the common manifestations. Family history of similar cases with parental consanguinity in Schizencephaly cases gives a clue to the autosomal recessive mode of inheritance. Family history of similar cases of Schizencephaly without any history of consanguinity indicates an autosomal pattern of inheritance. Key words: Neuronal Migrational Disorders, Lissencephaly, Schizencephaly, Cognitive Developmental Delay and Neuro-imaging.    DOI = 10.3126/jnps.v28i1.1399   J. Nepal Paediatr. Soc. Vol.28(1) p.10-13

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