scholarly journals Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect induced osteoarthritis rat model

2014 ◽  
Vol 22 (7) ◽  
pp. 1061-1067 ◽  
Author(s):  
J. Qin ◽  
S.K.-H. Chow ◽  
A. Guo ◽  
W.-N. Wong ◽  
K.-S. Leung ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Bone Formation ◽  
Rat Model ◽  
High Frequency ◽  
Cruciate Ligament ◽  
Cartilage Degeneration ◽  
High Frequency Vibration ◽  
Anterior Cruciate ◽  
Epiphyseal Bone ◽  
Low Magnitude

Effect of Remnant-Preserving Reconstruction of Acute Anterior Cruciate Ligament Injuries in a Rabbit Model: Histological and Biomechanical Analysis

2022 ◽  
Vol 12 (5) ◽  
pp. 897-906
Author(s):  
XiaoChen Ju ◽  
Hao Chai ◽  
Sasirekha Krishnan ◽  
Abinaya Jaisankar ◽  
Murugan Ramalingam ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Articular Cartilage ◽  
Acl Reconstruction ◽  
Bone Healing ◽  
Cruciate Ligament ◽  
Cartilage Degeneration ◽  
Remnant Preservation ◽  
Model Animal ◽  
Anterior Cruciate ◽  
Articular Cartilage Degeneration

Acute anterior cruciate ligament (ACL) is a key structure that stabilizes knee joints. The objective of this research is to investigate the influence of ligament remnants preserved on the tendon-bone healing following ACL reconstruction and to examine postoperative articular cartilage degeneration in rabbit as a model animal. Sixty New Zealand rabbits are randomly divided into an ACL reconstruction without remnant preservation group (Group A; n = 30) or ACL reconstruction with remnant preservation group (Group B; n = 30). The expression of HIF-1α, VEGF, and micro vessel density (MVD) in the transplanted tendon was detected by immunohistochemical staining at week 6 and 12 after the operation. The signal intensity of the transplanted tendon was observed by MRI scanning, and the width of the bone tunnel was measured by CT scanning at week 6 and 12 after the operation. The graft biomechanics was tested 12 weeks after the operation. The JNK and MMP-13 expression levels were compared to analyze the cartilage degeneration of the knee at week 12 after the operation. The experimental results were analyzed and showed that the remnant-preserving ACL reconstruction is beneficial for bone healing of the tendon in rabbits, but ACL reconstruction with or without ligament remnants preserved will not affect knee articular cartilage degeneration post-surgery.

A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament in a Rat Model

2020 ◽  
Author(s):  
Yohei Kawakami ◽  
Kazuhiro Nonaka ◽  
Naomasa Fukase ◽  
Antonio D’ Amore ◽  
Yoichi Murata ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Rat Model ◽  
Cruciate Ligament ◽  
Artificial Ligament ◽  
A Cell ◽  
Anterior Cruciate

A Novel Joint Loading System to Investigate the Effect of Daily Mechanical Load on a Healing Anterior Cruciate Ligament (ACL) Reconstruction

2009 ◽  
Author(s):  
Mark Stasiak ◽  
Peter Torzilli ◽  
Carl Imhauser ◽  
Jonathan Packer ◽  
Asheesh Bedi ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Knee Joint ◽  
Acl Reconstruction ◽  
Rat Model ◽  
Mechanical Load ◽  
Cruciate Ligament ◽  
Joint Distraction ◽  
The Us ◽  
Loading System ◽  
Anterior Cruciate

A novel system was developed to investigate the effect of mechanical load on tendon to bone healing, using a rat model of ACL reconstruction. A greater understanding of the effects of mechanical load may improve rehabilitation practices for the more than 100,000 ACL reconstructions each year in the US alone.[1] The purpose of this study was to assess: the accuracy of knee joint distraction, variability in fixator compliance, and ability of animals to tolerate the fixator over a typical loading protocol.

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