Association of serum potassium level with early and late mortality in elderly patients with acute kidney injury

Introduction: In the elderly, impairment of kidney function occurs. Renal diseases overlap with anatomic and functional changes related to age-related involutionary processes. Mortality among patients with acute renal injury is approximately 50%, despite advances in treatment and diagnosis of AKI. The aim: To assess the incidence of acute kidney injury in elderly patients and to analyze the causes of acute renal failure depending on age. Materials and methods: A retrospective analysis included medical documentation of patients hospitalized in the Nephrology Clinic during the 6-month period. During this period 452 patients were hospitalized in the clinic. A group of 77 patients with acute renal failure as a reason for hospitalization was included in the study. Results: The prerenal form was the most common cause of AKI in both age groups. In both age groups, the most common cause was dehydration; in the group of patients up to 65 years of age, dehydration was 29.17%; in the group of people over 65 years - 43.39%. Renal replacement therapy in patients with AKI was used in 14.29% of patients. In the group of patients up to 65 years of age hemodialysis was 16.67% and above 65 years of age. -13.21% of patients. The average creatinine level in the group of younger patients at admission was 5.16 ± 3.71 mg / dl, in the group of older patients 3.14 ± 1.63 mg / dl. The size of glomerular filtration GFR in the group of younger patients at admission was 21.14 ± 19.54 ml / min, in the group of older patients 23.34 ± 13.33 ml / min. Conclusions: The main cause of acute kidney injury regardless of the age group was dehydration. Due to the high percentage of AKI in the elderly, this group requires more preventive action, not only in the hospital but also at home.

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Antithrombin III Protects Against Acute Kidney Injury in Septic Elderly Patients

SSRN Electronic Journal ◽

10.2139/ssrn.3354676 ◽

2019 ◽

Author(s):

Yun Xie ◽

Rui Tian ◽

Wei Jin ◽

Hui Xie ◽

Jiang Du ◽

...

Keyword(s):

Acute Kidney Injury ◽

Elderly Patients ◽

Antithrombin Iii ◽

Kidney Injury

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Effects of angiotensin II receptor blockers on serum potassium level and hyperkalemia risk: retrospective single-centre analysis

European Journal of Hospital Pharmacy ◽

10.1136/ejhpharm-2021-002739 ◽

2021 ◽

pp. ejhpharm-2021-002739

Author(s):

Sakae Fukushima ◽

Manami Oishi ◽

Hiroya Aso ◽

Kifumi Arai ◽

Yuuki Sasaki ◽

...

Keyword(s):

Angiotensin Ii ◽

Serum Potassium ◽

Potassium Level ◽

Serum Potassium Level ◽

Angiotensin Ii Receptor Blockers ◽

Angiotensin Ii Receptor ◽

Single Centre ◽

Receptor Blockers

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Nutritional status and risk of contrast-associated acute kidney injury in elderly patients undergoing percutaneous coronary intervention

Clinical and Experimental Nephrology ◽

10.1007/s10157-021-02061-4 ◽

2021 ◽

Author(s):

Xiaoqi Wei ◽

Hanchuan Chen ◽

Zhebin You ◽

Jie Yang ◽

Haoming He ◽

...

Keyword(s):

Risk Factors ◽

Acute Kidney Injury ◽

Percutaneous Coronary Intervention ◽

Nutritional Status ◽

Elderly Patients ◽

Kidney Injury ◽

Coronary Intervention ◽

Severe Malnutrition ◽

Percutaneous Coronary ◽

Conut Score

Abstract Background This study aimed to investigate the connection between malnutrition evaluated by the Controlling Nutritional Status (CONUT) score and the risk of contrast-associated acute kidney injury (CA-AKI) in elderly patients who underwent percutaneous coronary intervention (PCI). Methods A total of 1308 patients aged over 75 years undergoing PCI was included. Based on the CONUT score, patients were assigned to normal (0–1), mild malnutrition (2–4), moderate-severe malnutrition group (≥ 5). The primary outcome was CA-AKI (an absolute increase in ≥ 0.3 mg/dL or ≥ 50% relative serum creatinine increase 48 h after contrast medium exposure). Results Overall, the incidence of CA-AKI in normal, mild, moderate-severe malnutrition group was 10.8%, 11.0%, and 27.2%, respectively (p < 0.01). Compared with moderate-severe malnutrition group, the normal group and the mild malnutrition group showed significant lower risk of CA-AKI in models adjusting for risk factors for CA-AKI and variables in univariate analysis (odds ratio [OR] = 0.48, 95% confidence interval [CI]: 0.26–0.89, p = 0.02; OR = 0.46, 95%CI: 0.26–0.82, p = 0.009, respectively). Furthermore, the relationship were consistent across the subgroups classified by risk factors for CA-AKI except anemia. The risk of CA-AKI related with CONUT score was stronger in patients with anemia. (overall interaction p by CONUT score = 0.012). Conclusion Moderate-severe malnutrition is associated with higher risk of CA-AKI in elderly patients undergoing PCI.

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