Serum potassium level as a biomarker for acute caffeine poisoning

The presented article contains the clinical observation of bradycardia development in 64-year-old patient with chronic kidney disease who was in ambulatory treatment at the hemodialysis department. During electrocardiogram recording an arrhythmia was detected as a junctional rhythm. The specific changes on electrocardiogram, presence of risk factors, and data of additional collection of history disease allowed purposing the development of dangerous condition — hyperkalemia. The diagnosis was confirmed after detection of the serum potassium level. This case illustrates the necessity to consider the possibility of hyperkalemia in patients with chronic kidney diseases including those who undergoing hemodialysis treatment. Relevant clinical manifestations and changes on the electrocardiogram require the urgent assessment of the serum potassium level for timely and adequate correction of the electrolyte disorder.

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Serum Potassium Levels and Adverse Outcomes in Patients with Acute Myocardial Infarction

Esculapio ◽

10.51273/esc21.251711 ◽

2021 ◽

Vol 17 (1) ◽

pp. 5-8

Author(s):

Rizwan Abbas ◽

Tazeen Nazar ◽

Bilal Aziz ◽

Furqan Saeed ◽

Kashif Nawaz ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Serum Potassium ◽

Potassium Level ◽

Adverse Outcome ◽

Serum Potassium Level ◽

Computer Software ◽

Case Series ◽

Adverse Outcomes ◽

Low Serum

Objective: To determine the effect of serum potassium levels on short term mortality outcomes in patients with acute myocardial infarction. Methods: This Descriptive Case Series was conducted in the CCU of Mayo Hospital Lahore from 15th November, 2017 to 15th May, 2018. A total of 156 patients of either sex between the age group of 30-60 years and diagnosed as cases of myocardial infarction with symptoms of less than 24 hours duration and serum potassium level of <3.5 mEq/L were included in the study. Patients were then followed up for 7 days and adverse outcome was recorded. Data was analyzed using computer software SPSS Version 22.0. Results: Out of the 156 patients, 119 (76.3%) were males and 37 (23.7%) were females. Mean age of the patients was 47.88±6.24 years, mean weight 85.31±13.14 Kg, mean duration of presenting complaints was 10.269±4.51 hours and mean Serum Potassium levels were 3.05±0.25 mEq/L. Adverse outcome in the form of mortality due to arrhythmias was seen in 15 (9.6%) patients. Conclusion: Low serum potassium level (<3.5mEq/L/L) was significantly associated with increased adverse outcome in acute myocardial infarction patients. Keywords: Acute myocardial infarction, Low serum potassium levels, Adverse outcome How to cite: Abbas R., Nazar T, Aziz B., Saeed F., Nawaz K., Nabeel M. serum potassium levels and adverse outcomes in patients with acute myocardial infarction. Esculapio 2021;17(01):5-8

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The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction

International Journal of Cardiology ◽

10.1016/j.ijcard.2016.07.024 ◽

2016 ◽

Vol 221 ◽

pp. 505-510 ◽

Cited By ~ 14

Author(s):

Muhammed Keskin ◽

Adnan Kaya ◽

Mustafa Adem Tatlısu ◽

Mert İlker Hayıroğlu ◽

Osman Uzman ◽

...

Keyword(s):

Myocardial Infarction ◽

Serum Potassium ◽

Potassium Level ◽

Serum Potassium Level ◽

St Elevation Myocardial Infarction ◽

St Elevation ◽

Long Term Mortality

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The Incidence And Risk Factors of Serum Hypokalemia After Primary Total Joint Arthroplasty

10.21203/rs.3.rs-1029175/v1 ◽

2021 ◽

Author(s):

Pin Pan ◽

Zitao Zhang ◽

Xiaofeng Zhang ◽

Qing Jiang ◽

Zhihong Xu

Keyword(s):

Risk Factors ◽

Red Blood Cells ◽

Knee Replacement ◽

Serum Potassium ◽

Total Joint Arthroplasty ◽

Blood Cells ◽

Potassium Level ◽

Serum Potassium Level ◽

Joint Arthroplasty ◽

Regular Monitoring

Abstract Background: Regular monitoring of serum potassium after total joint arthroplasty (TJA) is a routine examination, which can detect abnormal serum potassium and reduce adverse events timely caused by postoperative hypokalemia. In this study, we aimed to investigate the incidence and risk factors of hypokalemia after primary total hip and knee replacement.Methods: This study included patients who underwent unilateral total knee or hip arthroplasty in our department from April 2017 to March 2018. The serum potassium level before and after operation was collected and retrospectively analyzed. The differences in age, BMI and other factors between hypokalemia patients and non-hypokalemia patients at different time points after surgery were compared, and then the risk factors of postoperative hypokalemia were analyzed based on multiple logistic regression.Results: The total incidence of postoperative hypokalemia was 53.1%, while the respective rate on the first, third and fifth postoperative day was 12.5%, 40.7% and 9.6%. The serum potassium level on the first, third and fifth postoperative day was 3.84±0.32mmol/l, 3.59±0.34mmol/l and 3.80±0.32mmol/l, while among which, the level on the third day was the lowest (p=0.015). The independent risk factors for hypokalemia after total hip and knee replacement were the level of preoperative serum potassium (p=0.011), preoperative red blood cells (p=0.027), and a history of diabetes (p=0.007).Conclusion: Regular monitoring of serum potassium should be performed after TJA due to hypokalemia was a very common complication. We need to pay more attention to patients’ preoperative potassium and red blood cells, especially patients with diabetes.

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Sodium-Glucose Cotransporter-2 Inhibitors and the Risk of Abnormal Serum Potassium Level

Clinical Journal of the American Society of Nephrology ◽

10.2215/cjn.02130221 ◽

2021 ◽

Vol 16 (7) ◽

pp. 1094-1096

Author(s):

Y. Joseph Hwang ◽

Beini Lyu ◽

Alex R. Chang ◽

Lesley A. Inker ◽

Morgan E. Grams ◽

...

Keyword(s):

Serum Potassium ◽

Potassium Level ◽

Serum Potassium Level ◽

Sodium Glucose Cotransporter

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ON THE MECHANISM OF THE DEPRESSION OF THE SERUM POTASSIUM LEVEL BY EPINEPHRINE

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1940.130.3.562 ◽

1940 ◽

Vol 130 (3) ◽

pp. 562-567 ◽

Cited By ~ 6

Author(s):

Paul S. Larson

Keyword(s):

Serum Potassium ◽

Potassium Level ◽

Serum Potassium Level

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P1445ESPECIALLY HYPOKALEMIA IS A RISK FACTOR FOR ALL-CAUSE MORTALITY IN INCIDENT HEMODIALYSIS PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p1445 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Esther De Rooij ◽

Friedo W Dekker ◽

Saskia Le Cessie ◽

Johan W De Fijter ◽

Ellen K Hoogeveen

Keyword(s):

Risk Factor ◽

Kidney Function ◽

Serum Potassium ◽

Potassium Level ◽

Proportional Hazards Model ◽

Serum Potassium Level ◽

Hemodialysis Patients ◽

Cox Proportional Hazards Model ◽

Residual Kidney Function ◽

All Cause Mortality

Abstract Background and Aims Both hypo- and hyperkalemia can potentially induce fatal cardiac arrhythmias in the general population. However, little is known about the effect of potassium as a modifiable risk factor in hemodialysis (HD) patients. Therefore, we investigated the relation between serum potassium level and all-cause mortality in incident HD patients and whether there is an optimum serum potassium level to pursue. Method All incident HD patients (>18 y) from the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD), a prospective multi-center cohort study, were included. These patients were followed from the start of their first dialysis treatment until death, transplantation or a maximum of 2 years. Serum potassium levels were obtained at fixed 6-month time intervals and divided into six categories: ≤ 4.0, > 4.0 - ≤ 4.5, > 4.5 - ≤ 5.0, > 5.0 - ≤ 5.5 (reference), > 5.5 - ≤ 6.0 and > 6.0 mmol/L. Using a Cox proportional-hazards model with serum potassium category as a time-dependent variable, hazard ratios (HR) for all-cause mortality were calculated, adjusted for baseline age, sex, current smoking, diabetes and residual kidney function. Results In total, 1278 HD patients were included. At baseline, mean (±SD) age was 64 (±14) years, 60% were men, 23% were current smokers, 21% had diabetes and the median (interquartile range) residual kidney function was 3.0 (1.5-4.8) ml/min/1.73m2. Mean (±SD) serum potassium level was 4.8 (±0.8) mmol/L. The prevalence of the six potassium categories was: 10%, 19%, 26%, 22%, 15% and 8%, respectively. A total of 298 (23%) deaths was observed during 2 years of follow-up. After multivariable adjustment the HR (95% CI) for any death according to the six potassium categories were: 2.5 (1.5-4.3), 1.9 (1.2-3.0), 1.6 (1.0-2.5), 1 (reference), 1.3 (0.8-2.2) and 1.7 (1.0-3.0). Conclusion We found a U-shaped relation between serum potassium and all-cause mortality in incident hemodialysis patients. Especially, low serum potassium was a 2.5-fold stronger risk factor for all-cause mortality compared to normal serum potassium. Our results indicate an optimum serum potassium level between 5.0 - 5.5 mmol/L, emphasizing that potassium lowering therapy should be used with caution in hemodialysis patients.

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