pbaRapid and sensitive LC-MS/MS method for the enantioanalysis of verapamil in rat plasma using superficially porous silica isopropyl-cyclofructan 6 chiral stationary phase after SPE: Application to a stereoselective pharmacokinetic study

2021 ◽  
pp. 114108
Author(s):  
Mohamed Hefnawy ◽  
Abdulrhman Al-Majed ◽  
Haitham Alrabiah ◽  
Nasser Algrain ◽  
Mostafa Mohammed ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Pharmacokinetic Study ◽  
Chiral Stationary Phase ◽  
Porous Silica ◽  
Rat Plasma

Stereoselective HPLC analysis of tertatolol in rat plasma using macrocyclic antibiotic chiral stationary phase

Chirality ◽  
2010 ◽  
Vol 23 (4) ◽  
pp. 333-338 ◽  
Author(s):  
Mohamed M. Hefnawy ◽  
Yousif A. Asiri ◽  
Nourah Z. Al-Zoman ◽  
Gamal. A. Mostafa ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Stationary Phase ◽  
Hplc Analysis ◽  
Chiral Stationary Phase ◽  
Rat Plasma ◽  
Macrocyclic Antibiotic

Preparation, characterisation and enantioselective separation properties of a chiral stationary phase based on silica beads coated with a 2-hydroxypropyl-β-cyclodextrin polymer

e-Polymers ◽  
2003 ◽  
Vol 3 (1) ◽  
Author(s):  
Benjamin Carbonnier ◽  
Ludovic Janus ◽  
André Deratani ◽  
Michel Morcellet
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Structural Parameters ◽  
Porous Silica ◽  
Nitrogen Adsorption ◽  
Water Soluble ◽  
Size Exclusion ◽  
Adsorption Method ◽  
Cyclodextrin Polymer ◽  
Silica Beads

Abstract This paper describes the preparation of a chiral stationary phase based on a 2-hydroxypropyl-β-cyclodextrin polymer coated on porous silica. This method requires first the synthesis of a water-soluble cyclodextrin polymer carried out by the polycondensation of 2-hydroxypropyl-β-cyclodextrin with epichlorohydrin under controlled conditions. In the second step, the obtained copolymer was immobilised onto the porous silica surface by physisorption. The macromolecular features of the copolymer were investigated by size exclusion chromatography coupled with a multiple angle laser-light scattering detector. The evolution of the structural parameters of the modified silica beads (specific surface area and pore size distribution) was determined using a nitrogen adsorption method. The enantio-separation capability of the coated silica phase was evaluated for different polycyclic molecules. It was found that the enantioselectivity was strongly influenced by the geometry and shape of the solutes under study and the presence of an acidic modifier in the mobile phase.

Quantification of annonacin in Rat plasma: Application to pharmacokinetic study

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
N Bonneau ◽  
I Schmitz Afonso ◽  
D Touboul ◽  
A Brunelle ◽  
P Champy
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma

Chiral drugs separation by a new antibiotics-based chiral stationary phase

2014 ◽  
Author(s):  
Chunye Liu ◽  
Yanqing Miao ◽  
Yihui Guo ◽  
Yinjuan An ◽  
Yunfang Li ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Drugs ◽  
New Antibiotics
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