Factors associated with adverse pregnancy outcomes in women with antiphospholipid syndrome: A multicenter study

2017 ◽  
Vol 122 ◽  
pp. 21-27 ◽  
Author(s):  
Masashi Deguchi ◽  
Hideto Yamada ◽  
Mayumi Sugiura-Ogasawara ◽  
Mamoru Morikawa ◽  
Daisuke Fujita ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Multicenter Study ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Factors Associated ◽  
Adverse Pregnancy

scholarly journals Low Preconception Complement Levels Are Associated with Adverse Pregnancy Outcomes in a Multicenter Study of 260 Pregnancies in 197 Women with Antiphospholipid Syndrome or Carriers of Antiphospholipid Antibodies

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 671
Author(s):  
Cecilia Nalli ◽  
Daniele Lini ◽  
Laura Andreoli ◽  
Francesca Crisafulli ◽  
Micaela Fredi ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Multicenter Study ◽  
Pregnancy Outcomes ◽  
Antiphospholipid Antibodies ◽  
Pregnancy Loss ◽  
Fetal Loss ◽  
Adverse Pregnancy Outcomes ◽  
Experimental Animal Models ◽  
Increased Risk ◽  
Adverse Pregnancy

Antiphospholipid antibodies (aPL) can induce fetal loss in experimental animal models. Human studies did find hypocomplementemia associated with pregnancy complications in patients with antiphospholipid syndrome (APS), but these results are not unanimously confirmed. To investigate if the detection of low C3/C4 could be considered a risk factor for adverse pregnancy outcomes (APO) in APS and aPL carriers’ pregnancies we performed a multicenter study including 503 pregnancies from 11 Italian and 1 Russian centers. Data in women with APS and asymptomatic carriers with persistently positive aPL and preconception complement levels were available for 260 pregnancies. In pregnancies with low preconception C3/C4, a significantly higher prevalence of pregnancy losses was observed (p = 0.008). A subgroup analysis focusing on triple aPL-positive patients found that preconception low C3 and/or C4 levels were associated with an increased rate of pregnancy loss (p = 0.05). Our findings confirm that decreased complement levels before pregnancy are associated with increased risk of APO. This has been seen only in women with triple aPL positivity, indeed single or double positivity does not show this trend. Complement levels are cheap and easy to be measured therefore they could represent a useful aid to identify patients at increased risk of pregnancy loss.

scholarly journals Factors associated with sub-microscopic placental malaria and its association with adverse pregnancy outcomes among HIV-negative women in Dar es Salaam, Tanzania: a cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Aneth Vedastus Kalinjuma ◽  
Anne Marie Darling ◽  
Ferdinand M. Mugusi ◽  
Ajibola Ibraheem Abioye ◽  
Fredros O. Okumu ◽  
...  
Keyword(s):  
Birth Weight ◽  
Pregnancy Outcomes ◽  
Malaria Infection ◽  
Placental Malaria ◽  
Adverse Pregnancy Outcomes ◽  
Placental Infection ◽  
Factors Associated ◽  
Adverse Pregnancy ◽  
Prevention Methods ◽  
Dna Pcr

Abstract Background Malaria infection during pregnancy has negative health consequences for both mothers and offspring. Sub-microscopic malaria infection during pregnancy is common in most African countries. We sought to identify factors associated with sub-microscopic placental malaria, and its association with adverse pregnancy outcomes among HIV-negative pregnant women in Dar es Salaam, Tanzania. Methods We recruited a cohort of pregnant women during their first trimester and assessed for the occurrence of placental malaria and pregnancy outcomes. The follow-up was done monthly from recruitment until delivery. Histopathology placental malaria positive results were defined as the presence of malaria pigment or parasitized erythrocytes on the slide (histology-positive (HP)), and the sub-microscopic placental infection was defined as positive Plasmodium falciparum DNA by polymerase chain reaction (DNA PCR) amplification in a negative histopathology test. Adverse pregnancy outcomes investigated included low birth weight (birth weight below 2.5 kg), prematurity (live birth below 37 weeks), and small-for-gestational-age (SGA) (live born with a birth weight below 10th percentile for gestational age and sex). Weighted baseline category logit, log-binomial, and log-Poisson models were used to assess factors associated with placental malaria, and its association with adverse pregnancy outcomes. Results Among 1115 women who had histopathology and DNA PCR performed, 93 (8%) had HP placental infection, and 136 (12%) had the sub-microscopic placental infection. The risk of sub-microscopic placental malaria was greater in women who did not use mosquito prevention methods such as bed nets, fumigation, or mosquito coils (odds ratio (OR) = 1.75; 95% confidence interval (CI): 1.05–2.92; P = 0.03) and in women who were anemic (OR = 1.59; 95% CI: 1.20–2.11; P = 0.001). Women who were underweight had reduced odds of sub-microscopic placental malaria infection (OR = 0.33; 95% CI: 0.17–0.62; P = 0.001). Women who were overweight/obese had 1.48 times higher the odds of HP placental malaria compared to normal weight (OR = 1.48; 95% CI: 1.03–2.11; P = 0.03). HP placental malaria infection was associated with an increased risk of SGA births (RR = 1.30, 95% CI: 0.98–1.72, P = 0.07). In contrast, the sub-microscopic infection was associated with a reduced risk of SGA births (RR = 0.61, 95% CI: 0.43–0.88, P = 0.01). Placental malaria was not associated with low birth weight or prematurity. Conclusion Malaria prevention methods and maternal nutrition status during early pregnancy were important predictors of sub-microscopic placental malaria. More research is needed to understand sub-microscopic placental malaria and the possible mechanisms mediating the association between placental malaria and SGA.

Factors associated with adverse pregnancy outcomes in women with systemic lupus erythematosus

2016 ◽  
Vol 118 ◽  
pp. 114-115
Author(s):  
Haruka Muto ◽  
Takeshi Kanagawa ◽  
Masako Kanda ◽  
Ayako Inatomi ◽  
Haruna Kawaguchi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Systemic Lupus ◽  
Factors Associated ◽  
Adverse Pregnancy

Antiphospholipid syndrome characteristics and adverse pregnancy outcomes after 20 weeks of pregnancy

2018 ◽  
Vol 142 (2) ◽  
pp. 214-220 ◽  
Author(s):  
Rinat Gabbay-Benziv ◽  
Hadas Zafrir-Danieli ◽  
Dorit Blickstein ◽  
Anat Shmueli ◽  
Lina Salman ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy

scholarly journals Factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus

2018 ◽  
Vol 125 ◽  
pp. 39-44 ◽  
Author(s):  
Masashi Deguchi ◽  
Yoko Maesawa ◽  
Shino Kubota ◽  
Mayumi Morizane ◽  
Kenji Tanimura ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Systematic Lupus Erythematosus ◽  
Factors Associated ◽  
Adverse Pregnancy

scholarly journals Factors associated with birthweight and adverse pregnancy outcomes among children in rural Guinea-Bissau - a prospective observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alexander Dahl Stjernholm ◽  
Sanne Marie Thysen ◽  
Igualdino Da Silva Borges ◽  
Ane Bærent Fisker
Keyword(s):  
Observational Study ◽  
Pregnancy Outcomes ◽  
Prospective Observational Study ◽  
Low Birthweight ◽  
Randomised Trial ◽  
Adverse Pregnancy Outcomes ◽  
Factors Associated ◽  
Guinea Bissau ◽  
Adverse Pregnancy ◽  
At Home

Abstract Background Low birthweight (LBW) is associated with higher mortality and morbidity, but there is limited data on the prevalence of LBW in rural Africa, where many births occur at home. The Bacillus Calmette-Guérin (BCG) vaccine has non-specific effects. Studies suggest that maternal BCG-vaccination may affect the health of the child. Methods The present study is nested within a randomised trial in rural Guinea-Bissau: Pregnancies were registered at two-monthly village visits, where information on BCG scar status and other background factors were obtained. Children were enrolled in the trial and weighed at home within 72 h after birth. In this prospective observational study, we assessed factors associated with adverse pregnancy outcomes and birthweight in binomial and linear regression models. Results Among 1320 women who had their BCG scar status assessed, 848 (64%) had a scar, 472 (36%) had no scar. The risk of adverse pregnancy outcomes (miscarriages, stillbirths, early neonatal deaths) tended to be higher among BCG scar-negative women (13%) than among women with a BCG scar (10%), adjusted prevalence ratio = 1.29 (0.99–1.68). Birthweight was assessed for 628 (50%) of the 1232 live born children. The mean birthweight was 2.89 kg (SD 0.43) and the proportion of LBW children was 17% (104/628). Sex, twinning, region of birth, maternal age, maternal mid-upper arm circumference (MUAC), antenatal consultations, parity and possession of a mobile phone were associated with birthweight, while maternal BCG scar status was not. Conclusions This study provides the first birthweight data for home-born children in rural Guinea-Bissau, with a mean birthweight of 2.89 kg (SD 0.43) and a LBW prevalence of 17%. We found a tendency for higher risk of adverse pregnancy outcomes among BCG scar-negative women. Birthweight was similar in children of mothers with and without BCG scar.

scholarly journals Factors associated with adverse pregnancy outcomes among women who delivered at intermediate hospital oshakati, Namibia

2016 ◽  
Vol 5 (1) ◽  
pp. 5
Author(s):  
Teopolina Natangwe Mungoba ◽  
Kabwebwe Honore Mitonga ◽  
Sabina Aishe David ◽  
Alfred Musekiwa ◽  
Tuyakula Nakale
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Haemoglobin Level ◽  
Rural Area ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Maternal Deaths ◽  
Factors Associated ◽  
Gestational Period ◽  
Adverse Pregnancy

Background: Globally, the leading cause of death among females aged 15-49 years old is maternal mortality. More than 1,500 women die each day from pregnancy related causes resulting in an estimated 550,000 maternal deaths annually. We identified risk factors associated with adverse pregnancy outcomes.Methods: We conducted a descriptive, cross-sectional study, in which we administered a structured questionnaire through face to face interviews. We also applied the multivariate logistic regression model to determine factors associated with adverse pregnancy outcomes.Results: We enrolled a total of 306 pregnant women of whom 50% (n=153) were 12-19 years old and 50% (n=153) were 20-45 years old. Maternal death occurred only in the 20-45 years old mothers (6/153, 3.9%). In multivariate analysis, living in a rural area (aOR2.00, 95% CI: 1.08 to 3.69, p=0.027), shorter gestational period [32-37 weeks] (aOR4.84, 95% CI: 2.31 to 10.14, p=0.0007), haemoglobin level <10gm% (aOR3.87, 95%CI: 1.79 to 8.39, p=0.001), obesity [BMI ≥ 30 kg/m2] (aOR4.89, 95% CI: 1.38 to 17.37, p=0.014) and moderately high blood pressure [SBP/DBP of 150/100-159/109] (aOR15.15, 95% CI: 1.78 to 128.68, p=0.013) were significantly associated with adverse pregnancy outcomes.Conclusion: In this study, we identified living in a rural area, shorter gestational period, haemoglobin level < 10gm%, obesity, and having moderately high blood pressure to be risk factors for adverse pregnancy outcomes. All the maternal deaths were in the 20-45 years old pregnant mothers. We recommend educating women on these risk factors in order to reduce the burden of adverse pregnancy outcomes.

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