scholarly journals Jejunal interposition reconstruction with a stomach preserving esophagectomy improves postoperative weight loss and reflux symptoms for esophageal cancer patients

2012 ◽  
Vol 178 (2) ◽  
pp. 700-707 ◽  
Author(s):  
Eiji Yamada ◽  
Yasuhiro Shirakawa ◽  
Tomoki Yamatsuji ◽  
Leon Sakuma ◽  
Munenori Takaoka ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Cancer Patients ◽  
Jejunal Interposition ◽  
Postoperative Weight Loss ◽  
Reflux Symptoms ◽  
Jejunal Interposition Reconstruction

A phase II study to examine the effectiveness of nutritional support with elemental diet for stage II/III gastric cancer patients receiving adjuvant chemotherapy with S-1 (OGSG 1108).

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 98-98
Author(s):  
Junji Kawada ◽  
Hiroshi Imamura ◽  
Jin Matsuyama ◽  
Junichi Fukui ◽  
Kazuhiro Nishikawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Weight Loss ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Nutritional Support ◽  
Elemental Diet ◽  
Stage Ii ◽  
Postoperative Weight Loss ◽  
Second Stage ◽  
Gastric Cancer Patients

98 Background: Postoperative weight loss after gastrectomy causes deterioration in patient’s quality of life and tolerance for adjuvant chemotherapy in gastric cancer patients. Nutritional support may prevent postoperative weight loss and chemotherapy related adverse effects to improve compliance of adjuvant chemotherapy. Methods: Clinical stage II/III gastric cancer patients received R0 resection were registered in the first stage of the present study. Those patients were qualified and enrolled in the second stage who could intake more than 60% of elemental diet (Elental, 300 kcal/day for 14 days) in the postoperative period and were proven pathological stage II/III. Enrolled patients were planned to receive a total of 300 kcal/day of Elental for 24 weeks and additional courses was permitted up to 365 days. The primary endpoint was compliance of S-1: percent of patients who accomplish S-1 adjuvant for one year with more than 70% relative performance (RP). The secondary endpoints were nutritional parameters (body weight, BMI, s-albumin, s-protein, s-cholesterol), RP of 8 courses of S-1, adverse effects of S-1, RP of Elental and ratio of patients who were enrolled to the second stage. Results: From January 2012 to September 2014, 149 patients were registered in the first stage and 82 patients were enrolled in the second stage: including 50 men; 32 women; median age of 70 years (range, 42-85 years); and performance status were zero in 45 and one in 37 patients. Compliances of S-1 were 60.5% (95%CI: 49.0, 71.2) in 81 eligible patients and 69% (95%CI: 56.9, 79.5) in eligible patients without recurrence. In 81 eligible patients, RP of 8 courses of S-1 was 87.3 % (95%CI: 88.3, 85.9), and the body weight loss was 1.80kg (95%CI: -0.38, 4.48). Grade 3-4 toxicities were neutropenia 12%, anemia 4%, anorexia 4% and diarrhea 4%. Conclusions: Nutritional support for gastric cancer patients receiving adjuvant chemotherapy contributes to increase compliance of S-1 and potential effect on survival may be expected. Clinical trial information: UMIN000006872.

Prognostic value of nutritional status for esophageal cancer patients undergoing neoadjuvant therapy and resection.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 133-133 ◽  
Author(s):  
Sabrina D Saeed ◽  
Jacques Fontaine ◽  
Luis Pena ◽  
Sarah E. Hoffe ◽  
Jessica Frakes ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Neoadjuvant Therapy ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Feeding Tube ◽  
Tube Placement ◽  
Significant Weight Loss ◽  
Increased Risk ◽  
The Impact

133 Background: Malnutrition, linked to decreased patient tolerance to chemotherapy and increased rates of therapy-related toxicity, negatively affects cancer prognosis. Esophageal carcinomas (EC) frequently present with dysphagia and significant weight loss which may be exacerbated by neoadjuvant chemoradiation, placing EC patients at an increased risk of malnutrition. We therefore aim to assess the prognostic value of pre-operative malnutrition for esophageal cancer patients undergoing neoadjuvant therapy (NAT). Methods: Query of our institution’s IRB approved database of 1113 EC patients (pts) identified 725 individuals who underwent NAT followed by resection from 1994-2018. Seventy-six pts were considered to be at higher nutritional risk during NAT, as indicated by significant weight loss and enteral feeding tube requirement (ETF+), while 644 did not receive pre-operative feeding tube placement (ETF–). Clinicopathologic characteristics, post-operative outcomes, and survival were compared between ETF+ and ETF– using various statistical methods. Results: Of the included pts, 83% were male with a median age of 64.5 (28-86) years. Between ETF+ (n = 76) and ETF– (n = 644), pt characteristics were balanced in terms of initial stage, age, histology and tumor location. A higher percentage of ETF+ pts had > 5% weight loss before NAT (32 vs. 6%; p < .01). ETF+ was associated with a significantly worse median survival (27 vs. 77 m; p < .01), but not with increased post-operative length of hospital stay (p = .69), complications (p = .20) or tumor recurrence (p = .89). Although completion of chemotherapy (p = .46) and radiation (p = .49) were comparable between ETF+ and ETF–, tumor response was worse in the ETF+ group (71 vs. 60% non-complete response; p = .02). Conclusions: Our results suggest that baseline malnutrition is a risk factor for poor survival and negatively impacts the efficacy of neoadjuvant therapy in EC patients. Poor response to NAT in malnourished patients may stem from impaired immune function. Future prospective studies should evaluate other parameters for nutritional assessment to further assess the impact of malnutrition on tumor regression and survival after NAT.

Tu1603 Prophylactic Effect of Rikkunshito on Body Weight Loss and Malnutrition Accompanied With Anorexia in Esophageal Cancer Patients After Esophagectomy

2014 ◽  
Vol 146 (5) ◽  
pp. S-1086
Author(s):  
Masaki Nakamura ◽  
Mikihito Nakamori ◽  
Toshiyasu Ojima ◽  
Masahiro Katsuda ◽  
Takeshi Iida ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Body Weight ◽  
Cancer Patients ◽  
Body Weight Loss ◽  
Prophylactic Effect

scholarly journals Variation by stage in the effects of prediagnosis weight loss on mortality in a prospective cohort of esophageal cancer patients

2017 ◽  
Vol 30 (9) ◽  
pp. 1-7 ◽  
Author(s):  
S. Shen ◽  
J. L. Araujo ◽  
N. K. Altorki ◽  
J. R. Sonett ◽  
A. Rodriguez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Cancer Patients ◽  
Prospective Cohort

scholarly journals Effect of Weight Loss on Survival in Esophageal Cancer Patients undergoing Neoadjuvant Chemoradiotherapy and Surgery

2020 ◽  
Vol 5 (2) ◽  
pp. 137-146
Author(s):  
Jia Hua Lyu ◽  
Tao Li ◽  
Yong Tao Han ◽  
Lei Wu ◽  
Lin Peng ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Cancer Patients ◽  
Neoadjuvant Chemoradiotherapy

Abstract 2637: Impact of pre-diagnosis weight loss on outcomes in a prospective cohort of esophageal cancer patients

2016 ◽  
Author(s):  
Sherry Shen ◽  
James L. Araujo ◽  
Nasser K. Altorki ◽  
Joshua R. Sonett ◽  
Adriana Rodriguez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Cancer Patients ◽  
Prospective Cohort

scholarly journals Nutritional Status and Feeding Regimen of Patients with Esophagus Cancer—A Study from Vietnam

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 289
Author(s):  
Binh Pham Van ◽  
Hoa Nguyen Thi Thanh ◽  
Huong Le Thi ◽  
Anh Nguyen Le Tuan ◽  
Hang Dang Thi Thu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Esophageal Cancer ◽  
Nutritional Status ◽  
Dietary Intake ◽  
Total Energy ◽  
Cancer Patients ◽  
Energy Intake ◽  
Strongly Correlated ◽  
Esophagus Cancer ◽  
Day By Day

Background: Esophagus cancer patients are at high risk of malnutrition. This study was performed to assess the nutritional status and dietary intake of newly diagnosed esophageal cancer patients in Vietnam National Cancer Hospital (NCH). Methods: A cross-sectional study was conducted on 206 early esophageal cancer inpatients after gastrostomy from September 2017 to June 2018. The chi-squared test, Fisher exact test, and Mann–Whitney test were performed. The software of the Vietnam National Institute of Nutrition was used to evaluate the dietary intake of patients. Results: All the participants were male with a mean age of 57.1 ± 8.5 years. Overall, 87.4% of patients had dysphagia. Furthermore, 82.5% and 90.8% of patients reported weight loss one and six months pre-diagnosis, respectively. Moreover, 52.9% of patients suffered from mild/moderate malnutrition and 29.6% of patients had severe malnutrition according to the Patient-Generated Subjective Global Assessment (PG-SGA). The body mass index (BMI) and mid upper arm circumference (MUAC) measurement revealed 47.6% and 50% of undernourished patients, respectively. The proportions of patients having malnutrition were 10.7%, 55.8%, and 27.2% according to albumin, prealbumin, and total lymphocyte counts, respectively. The means of energy, protein, lipid, and carbohydrate in the patients’ 24 h preoperative diets were 973.6 ± 443.0 kcal/day, 42.4 ± 21.6 g/day, 31.0 ± 15.5 g/day, and 130.0 ± 64.5 g/day. The total energy, total protein, animal protein, total lipid, and plant lipid in the dietary intake of patients were strongly correlated with age, economic classification, and PG-SGA (each p < 0.05). The total energy intake increased day by day, with the average energy intake of 1343.9 ± 521.3 kcal on the seventh day. Energy and protein response rates increased day by day and were highest at 7 days post-operation at 18.0% and 19.4%. Conclusion: Malnutrition and insufficient intake are noteworthy in esophageal cancer patients. The PG-SGA is strongly correlated with the dietary intake of patients. The results from this study will help medical staff to prevent malnutrition and improve the nutritional status of esophageal cancer inpatients. Furthermore, public awareness should be raised on recognizing weight loss as an early symptom of esophageal cancer and the utilization of preoperative assessment tools for nutritional assessment and malnutrition management.

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