Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage

2020 ◽  
Vol 29 (5) ◽  
pp. 104748 ◽  
Author(s):  
Chunyan Wang ◽  
Jingwei Cao ◽  
Shurong Duan ◽  
Ran Xu ◽  
Hongli Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Intracerebral Hemorrhage ◽  
Nerve Injury ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Marrow Mesenchymal Stem Cells

scholarly journals From Blood to the Brain: Can Systemically Transplanted Mesenchymal Stem Cells Cross the Blood-Brain Barrier?

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Linan Liu ◽  
Mark A. Eckert ◽  
Hamidreza Riazifar ◽  
Dong-Ku Kang ◽  
Dritan Agalliu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumors ◽  
Blood Brain Barrier ◽  
Inflammatory Diseases ◽  
Neurological Diseases ◽  
Brain Barrier ◽  
Therapeutic Effects ◽  
Blood Brain ◽  
The Brain

Systemically infused mesenchymal stem cells (MSCs) are emerging therapeutics for treating stroke, acute injuries, and inflammatory diseases of the central nervous system (CNS), as well as brain tumors due to their regenerative capacity and ability to secrete trophic, immune modulatory, or other engineered therapeutic factors. It is hypothesized that transplanted MSCs home to and engraft at ischemic and injured sites in the brain in order to exert their therapeutic effects. However, whether MSCs possess the ability to migrate across the blood-brain barrier (BBB) that separates the blood from the brain remains unresolved. This review analyzes recent advances in this area in an attempt to elucidate whether systemically infused MSCs are able to actively transmigrate across the CNS endothelium, particularly under conditions of injury or stroke. Understanding the fate of transplanted MSCs and their CNS trafficking mechanisms will facilitate the development of more effective stem-cell-based therapeutics and drug delivery systems to treat neurological diseases and brain tumors.

scholarly journals Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhuo Cheng ◽  
Liping Wang ◽  
Meijie Qu ◽  
Huaibin Liang ◽  
Wanlu Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

Effects of bone marrow mesenchymal stem cells transfected with Ang-1 gene on hyperoxia-induced optic nerve injury in neonatal mice

2018 ◽  
Vol 233 (11) ◽  
pp. 8567-8577 ◽  
Author(s):  
Fang-Yu Liu ◽  
Guang-Wu Li ◽  
Chang-Hua Sun ◽  
Sha Chen ◽  
Jun-Fei Cao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Optic Nerve ◽  
Nerve Injury ◽  
Optic Nerve Injury ◽  
Neonatal Mice ◽  
Marrow Mesenchymal Stem Cells
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