In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer’s disease

2015 ◽  
Vol 372 ◽  
pp. 107-117 ◽  
Author(s):  
Maleeha Waqar ◽  
Sidra Batool
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
In Silico ◽  
In Silico Analysis ◽  
Therapeutic Use ◽  
Silico Analysis

Double hit viral parasitism, polymicrobial CNS residency and perturbed proteostasis in Alzheimer’s disease: A data driven, in silico analysis of gene expression data

2020 ◽  
Vol 127 ◽  
pp. 124-135
Author(s):  
George D. Vavougios ◽  
Christiane Nday ◽  
Sygliti-Henrietta Pelidou ◽  
Sotirios G. Zarogiannis ◽  
Konstantinos I. Gourgoulianis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Expression Data ◽  
In Silico ◽  
In Silico Analysis ◽  
Data Driven ◽  
Expression Data ◽  
Double Hit ◽  
Silico Analysis

scholarly journals MicroRNAs Modulate the Pathogenesis of Alzheimer’s Disease: An In Silico Analysis in the Human Brain

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 983
Author(s):  
Agnese Gugliandolo ◽  
Luigi Chiricosta ◽  
Virginia Boccardi ◽  
Patrizia Mecocci ◽  
Placido Bramanti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nervous System ◽  
In Silico ◽  
Target Genes ◽  
Amyloid Β ◽  
In Silico Analysis ◽  
Protein Translation ◽  
Mirnas Expression ◽  
Silico Analysis

MicroRNAs (miRNAs) are small RNAs involved in the post-transcriptional regulation of their target genes, causing a decrease in protein translation from the mRNA. Different miRNAs are found in the nervous system, where they are involved in its physiological functions, but altered miRNAs expression was also reported in neurodegenerative disorders, including Alzheimer’s disease (AD). AD is characterized by memory loss, cognitive function abnormalities, and various neuropsychiatric disturbances. AD hallmarks are amyloid β (Aβ) aggregates, called senile plaques, and neurofibrillary tangles (NFTs) formed by hyperphosphorylated Tau protein. In this study, we performed an in silico analysis to evaluate altered patterns of miRNAs expression in the brains of AD patients compared to healthy subjects. We found 12 miRNAs that were differentially expressed in AD compared to healthy individuals. These miRNAs have target genes involved in AD pathogenesis. In particular, some miRNAs influence Aβ production, having as target secretase and amyloid precursor protein (APP). Some miRNAs were reported to be involved in nervous system functions, and their alteration can cause neuronal dysfunction.

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