293 DDX31 REGULATES P53 TUMOR SUPPRESSOR ACTIVITY THROUGH ITS INTERACTION WITH NPM1 IN RENAL CELL CARCINOMAS

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Tomoya Fukawa ◽  
Taisuke Matsuo ◽  
Masahiko Takemura ◽  
Yasuyo Yamamoto ◽  
Kunihisa Yamaguchi ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Renal Cell ◽  
Renal Cell Carcinomas ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity

Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor

TAp73α Increases p53 Tumor Suppressor Activity in Thyroid Cancer Cells via the Inhibition of Mdm2-Mediated Degradation

2008 ◽  
Vol 6 (1) ◽  
pp. 64-77 ◽  
Author(s):  
Roberta Malaguarnera ◽  
Veronica Vella ◽  
Giuseppe Pandini ◽  
Mariangela Sanfilippo ◽  
Vincenzo Pezzino ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Thyroid Cancer Cells

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

10.1038/ng894 ◽  
2002 ◽  
Vol 31 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Dmitry V. Bulavin ◽  
Oleg N. Demidov ◽  
Shin'ichi Saito ◽  
Paivikki Kauraniemi ◽  
Crissy Phillips ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Tumors ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity

The Ets Transcription Factor ELF5 Functions as a Tumor Suppressor in the Kidney

2011 ◽  
Vol 14 (4) ◽  
pp. 316-322 ◽  
Author(s):  
Erika J. Lapinskas ◽  
Suzanne Svobodova ◽  
Ian D. Davis ◽  
Jonathan Cebon ◽  
Paul J. Hertzog ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Promoter Regions ◽  
Suppressor Activity ◽  
Tumor Suppressor Activity ◽  
Ets Family

Renal cell carcinoma is an important clinical disease with poorly understood etiology. ELF5 is an epithelial-specific member of the Ets family of transcription factors, characterized by the 80 amino acid Ets domain that binds the purine-rich GGAA/T Ets motif found in the promoter regions of a variety of genes. Since ELF5 is highly expressed in kidney and has been postulated to function as a tumor suppressor, at least in the context of the breast, we investigated its role in kidney cancer. In renal cell carcinoma ELF5 expression was consistently decreased in tumor samples versus normal. ELF5 mRNA was decreased in 94% of lesions tested and ELF5 protein was undetectable in 40/40 kidney-derived carcinomas. Re-expression of the ELF5 gene in 786-O renal carcinoma cells suppressed their tumorigenic capacity in vitro and in vivo. This work is the first to suggest that ELF5 has tumor suppressor activity in the kidney.

scholarly journals Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions

Oncogene ◽  
2009 ◽  
Vol 28 (48) ◽  
pp. 4284-4294 ◽  
Author(s):  
D Walerych ◽  
M B Olszewski ◽  
M Gutkowska ◽  
A Helwak ◽  
M Zylicz ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Molecular Chaperones ◽  
Stress Conditions ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity
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