scholarly journals MP21-20 ANTIDEPRESSANT USE BY MEN UNDERGOING TREATMENT FOR LOCALIZED PROSTATE CANCER: A POPULATION BASED COHORT STUDY

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Rano Matta ◽  
Christopher J.D. Wallis ◽  
Amanda Hird ◽  
Erind Dvorani ◽  
Zachary Klaassen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Population Based ◽  
Localized Prostate Cancer ◽  
Antidepressant Use

scholarly journals Rates of primary and secondary treatments for patients on active surveillance for localized prostate cancer—A population‐based cohort study

2020 ◽  
Vol 9 (19) ◽  
pp. 6946-6953
Author(s):  
Rano Matta ◽  
Amanda E. Hird ◽  
Erind Dvorani ◽  
Refik Saskin ◽  
Gregory J. Nason ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Active Surveillance ◽  
Population Based ◽  
Localized Prostate Cancer

scholarly journals Comparative effectiveness of surgery and radiotherapy for survival of clinically localized prostate cancer patients: A population-based coarsened exact matching retrospective cohort study

2019 ◽  
Author(s):  
Masato Yasui ◽  
Masahiko Sakaguchi ◽  
Ryousuke Jikuya ◽  
Sohgo Tsutsumi ◽  
Tomoyuki Tatenuma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Elderly Patients ◽  
Cancer Patients ◽  
The Elderly ◽  
Population Based ◽  
Localized Prostate Cancer ◽  
Exact Matching ◽  
Coarsened Exact Matching ◽  
Significant Difference

Abstract Background. Radical prostatectomy and radiotherapy are currently the main treatment options for localized prostate cancer. However, not yet a large cohort study of comparison between surgery and radiation has been investigated in Japan nor Asia. Objective of this study was to compare the survival outcome between surgery and radiotherapy among patients with clinically localized prostate cancer and in the elderly and young patients. Methods. We retrospectively evaluated survival outcomes of localized prostate cancer patients (age at diagnosis ≤79 years, cT1-3) initially treated with surgery or radiotherapy. Data were collected from the population-based cancer registry of Kanagawa Prefecture, Japan. A 1:1 coarsened exact matching of age at diagnosis, clinical T stage, and cancer differentiation was made between the two treatment groups. Patients were also categorized into two groups by age at a cut-off of 70 years for analysis. Results. The cohort comprised 4,810 patients aged 50-79 years. No significant difference in CSS was observed between the two groups (p=0.612), but the surgery group had significantly better prognosis in OS (p=0.004). When stratified for age, similar tendencies were seen in the elderly group (aged 70-79 years) (p=0.961 and p=0.007, respectively). By contrast, no significant difference in either CSS or OS was found in the younger group (p=0.550 and p=0.408, respectively). Intrinsic deaths were more likely to occur in elderly patients treated with radiotherapy than in those undergoing surgery (69.3% vs 78.2%, p=0.128).Conclusions. Our data suggests that surgery provided significantly better OS than radiotherapy, particularly among the elderly. However, radiotherapy may be more appropriate in elderly patients due to less invasiveness of the procedure. Prospective trials evaluating these therapies are warranted.

417 Biochemical disease-free and overall survival of treatments for localized prostate cancer: Cohort study with a 7 year follow-up

2014 ◽  
Vol 13 (1) ◽  
pp. e417
Author(s):  
X. Bonet ◽  
J.F. Suárez ◽  
M. Castells ◽  
A.J. Vicéns ◽  
E. Franco ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Cohort Study ◽  
Localized Prostate Cancer ◽  
Disease Free

scholarly journals Acute urinary retention and risk of cancer: population based Danish cohort study

BMJ ◽  
2021 ◽  
pp. n2305
Author(s):  
Maria Bisgaard Bengtsen ◽  
Dóra Körmendiné Farkas ◽  
Michael Borre ◽  
Henrik Toft Sørensen ◽  
Mette Nørgaard
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Urinary Retention ◽  
Acute Urinary Retention ◽  
Absolute Risk ◽  
Population Based ◽  
Excess Risk ◽  
Tract Cancer ◽  
Urinary Tract Cancer

Abstract Objective To examine the risk of urogenital, colorectal, and neurological cancers after a first diagnosis of acute urinary retention. Design Nationwide population based cohort study. Setting All hospitals in Denmark. Participants 75 983 patients aged 50 years or older with a first hospital admission for acute urinary retention during 1995-2017. Main outcome measures Absolute risk of urogenital, colorectal, and neurological cancer and excess risk of these cancers among patients with acute urinary retention compared with the general population. Results The absolute risk of prostate cancer after a first diagnosis of acute urinary retention was 5.1% (n=3198) at three months, 6.7% (n=4233) at one year, and 8.5% (n=5217) at five years. Within three months of follow-up, 218 excess cases of prostate cancer per 1000 person years were detected. An additional 21 excess cases per 1000 person years were detected during three to less than 12 months of follow-up, but beyond 12 months the excess risk was negligible. Within three months of follow-up the excess risk for urinary tract cancer was 56 per 1000 person years, for genital cancer in women was 24 per 1000 person years, for colorectal cancer was 12 per 1000 person years, and for neurological cancer was 2 per 1000 person years. For most of the studied cancers, the excess risk was confined to within three months of follow-up, but the risk of prostate and urinary tract cancer remained increased during three to less than 12 months of follow-up. In women, an excess risk of invasive bladder cancer persisted for several years. Conclusions Acute urinary retention might be a clinical marker for occult urogenital, colorectal, and neurological cancers. Occult cancer should possibly be considered in patients aged 50 years or older presenting with acute urinary retention and no obvious underlying cause.

Associations between patient knowledge of others' experiences and treatment choice in men with localized prostate cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 6578-6578
Author(s):  
Aaron J. Katz ◽  
Ying Cao ◽  
Xinglei Shen ◽  
Deborah Usinger ◽  
Sarah Walden ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Decision Making ◽  
North Carolina ◽  
Cancer Patients ◽  
Treatment Options ◽  
Population Based ◽  
Treatment Choice ◽  
Localized Prostate Cancer ◽  
The North ◽  
Patient Reported

6578 Background: Men with localized prostate cancer must select from multiple treatment options, without one clear best choice. Consequently, personal factors, such as knowing other prostate cancer patients who have undergone treatment, may influence patient decision-making. However, associations between knowledge about others’ experiences and treatment decision-making among localized prostate cancer patients has not been well characterized. We used data from a population-based cohort of localized prostate cancer patients to examine whether patient-reported knowledge of others’ experiences is associated with treatment choice. Methods: The North Carolina Prostate Cancer Comparative Effectiveness & Survivorship Study (NC ProCESS) is a population-based cohort of localized prostate cancer patients enrolled from 2011-2013 throughout the state of North Carolina in collaboration with the North Carolina Central Cancer Registry. All patients were enrolled prior to treatment and followed prospectively. Patient decision-making factors including knowledge of others’ experiences with prostate cancer treatment options were collected through patient report. Patient treatment choice was determined through medical record abstraction and cancer registry data. Results: Among 1,202 patients, 17% reported knowing someone who pursued active surveillance (AS) while 28%, 46%, and 59% reported knowing someone who received brachytherapy, external beam radiation (EBRT), or radical prostatectomy (RP), respectively; 26% underwent AS, 9% brachytherapy, 21% EBRT, and 39% RP as their initial treatment. In unadjusted analyses, patients with knowledge of others’ experiences with brachytherapy, EBRT or RP had more than twice the odds of receiving that treatment compared to patients who did not. Knowledge of others’ experience with AS was not associated with choice to undergo AS. Multivariable analysis adjusting for age, race, risk group, and patient-reported goals of care showed knowledge of others’ experiences with brachytherapy (OR 4.60, 95% confidence interval [CI] 2.76 to 7.68), EBRT (OR 2.38, 95% CI 1.69 to 3.34), or RP (OR 4.02, 95% CI 2.84 to 5.70) was significantly associated with odds of receiving that treatment. The odds of receiving a particular treatment option were further increased among patients who reported knowing someone who had a “good” experience with the treatment in question. Conclusions: This is the first population-based study to directly demonstrate the impact of a patient’s knowledge of others’ experiences on treatment choice in prostate cancer. These data provide a new consideration to clinicians in their counseling of patients with newly diagnosed prostate cancer, and also impacts research into the informed decision-making process for this disease.

scholarly journals Digoxin use after diagnosis of prostate cancer and survival: a population-based cohort study

2016 ◽  
Vol 25 (9) ◽  
pp. 1099-1103 ◽  
Author(s):  
Reema A. Karasneh ◽  
Liam J. Murray ◽  
Carmel M. Hughes ◽  
Chris R. Cardwell
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Population Based
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