PCV119 Relationship Between Quality of Life and Level of Cardiovascular Risk and Comorbidities in Spanish Hipertensive Patients-Alhambra Study

Abstract Background The present study was designed to evaluate the metabolic profile, cardiovascular risk factors and quality of life in children with congenital adrenal hyperplasia (CAH) and compare it with age- and sex-matched controls. Methods Fifty-two patients aged 3–21 years with classic CAH due to 21-hydroxylase deficiency were included in the study. Metabolic profiling was done for 36 cases and compared with 28 healthy age- and sex-matched controls. Quality of life was assessed in all 52 children and their parents using a validated Pediatric Quality of Life Inventory (PedsQL) questionnaire and was compared with normative data from the same population. Results The median age was 12 years with 14 (27%) males and 38 (73%) females. Out of the total 52 patients, 35 (67%) had salt wasting and 17 (33%) had simple virilising CAH. The median height standard deviation score (SDS) of cases was similar to that of controls (−0.72 vs. −0.64, p = 0.57) and 81% of females had normal pubertal status indicating a good control of the disease. Weight SDS, body mass index (BMI) SDS, mean diastolic blood pressure and insulin resistance were significantly higher in cases when compared to controls (0.31 vs. −0.3; 0.96 vs. 0.17; 67.8 ± 10.49 vs. 61 ± 8.49 and 2.1 vs. 0.95, respectively). The quality of life was significantly reduced in all domains as per parents’ perspective, whereas the children reported reduced quality of social and school functioning. There was no significant correlation between quality of life and metabolic parameters. Conclusions Children with CAH despite a reasonably good control of the disease have a higher cardiovascular risk and reduced quality of life when compared to healthy controls.

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Cardiovascular Risk and Quality of Life in Elderly People with Mild Thyroid Hormone Deficiency

Frontiers in Endocrinology ◽

10.3389/fendo.2014.00153 ◽

2014 ◽

Vol 5 ◽

Cited By ~ 9

Author(s):

Sara Tognini ◽

Giuseppe Pasqualetti ◽

Valeria Calsolaro ◽

Antonio Polini ◽

Nadia Caraccio ◽

...

Keyword(s):

Quality Of Life ◽

Cardiovascular Risk ◽

Thyroid Hormone ◽

Elderly People ◽

Hormone Deficiency

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Long-term consequences of chronic PTSD on quality of life, cardiovascular risk and stress hormones in aging former refugee children

European Psychiatry ◽

10.1016/s0924-9338(11)72780-8 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1075-1075 ◽

Cited By ~ 1

Author(s):

C. Muhtz ◽

K. Godemann ◽

C. von Alm ◽

C. Wittekind ◽

K. Wiedemann ◽

...

Keyword(s):

Quality Of Life ◽

Cardiovascular Risk ◽

Salivary Cortisol ◽

Stress Hormones ◽

Ankle Brachial Index ◽

Refugee Children ◽

Chronic Ptsd ◽

Long Term Consequences

IntroductionSeveral studies suggested that having a history of posttraumatic stress disorder (PTSD) is associated with higher rates of somatic morbidity and disease.AimThe aim of the present study was to investigate systematically the long-term-consequences of PTSD on cardiovascular risk, quality of life and stress hormones in a sample of former refugee children.MethodsIn 25 subjects with chronic PTSD and 25 trauma-controlled subjects we measured variables of the metabolic syndrome supplemented by the ankle-brachial index and h-CRP. Quality of life was assessed by the SF-36. Cortisol, ACTH, DHEA were measured in the low dose dexamethasone-suppression-test. Additionally, salivary cortisol was assessed at 0800, 1200, 1600 and 2200 hours.ResultsWe found a significant group effect between participants with PTSD and without PTSD regarding quality of life, but not on any metabolic parameter including the ankle-brachial index or cortisol, ACTH and DHEA in plasma before and after dexamethasone or salivary cortisol.ConclusionChronic PTSD was associated with diminished quality of life more than six decades after traumatization, but not with altered metabolic or endocrine variables. Nevertheless, search for subgroups of PTSD patients with childhood traumatization leading to different metabolic and endocrine long-term consequences in aging PTSD patients is needed.

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Long-term effects of a Swedish lifestyle intervention programme on lifestyle habits and quality of life in people with increased cardiovascular risk

Scandinavian Journal of Public Health ◽

10.1177/1403494817746536 ◽

2017 ◽

Vol 46 (6) ◽

pp. 613-622 ◽

Cited By ~ 6

Author(s):

Matthias Lidin ◽

Elin Ekblom-Bak ◽

Monica Rydell Karlsson ◽

Mai-Lis Hellénius

Keyword(s):

Quality Of Life ◽

Cardiovascular Risk ◽

Dietary Habits ◽

Behavioural Change ◽

University Hospital ◽

Intervention Programme ◽

Lifestyle Habits ◽

Group Sessions ◽

One Year

Aims: The aim of this study was to evaluate the effects of a structured intervention programme on lifestyle habits and quality of life after six months and one year in participants with increased cardiovascular risk. Methods: Participants aged ≥18 years with increased cardiovascular risk were referred from primary health care and hospitals. The programme was launched at an outpatient clinic in a department of cardiology at a university hospital. It consisted of individual visits to a nurse for a health check-up and lifestyle counselling at baseline, after six months and at one year. In addition, five group sessions – focusing on nicotine, alcohol, physical activity, eating habits, stress, sleep and behavioural change – were offered to the participants and their relatives or friends. Lifestyle habits and quality of life were assessed with questionnaires at baseline, after six months and at one year. Results: One hundred participants (64 women, 36 men, age 58±11 years) were included in the programme. Compared with the baseline, significant and favourable changes in reported lifestyle habits were noted. Exercise levels were higher after one year and sedentary time decreased from 7.4 to 6.3 h/day. Dietary habits improved and the number of participants with a high consumption of alcohol decreased. Quality of life improved after one year. Conclusions: Participating in a structured lifestyle programme resulted in improved lifestyle habits and quality of life over one year in people with increased cardiovascular risk. Components such as an inter-professional teamwork, a focus on lifestyle rather than the disease, and combining individual visits and group sessions, might be central to the positive outcome of the programme.

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