■ Dr. Constantin Cope Medical Student Research Award Transcatheter intraarterial delivery of superparamagnetic iron oxide-labeled natural killer lymphocytes to hepatocellular carcinoma: longitudinal efficacy studies in a rat model

2013 ◽  
Vol 24 (4) ◽  
pp. S7
Author(s):  
A. Sheu ◽  
Z. Zhang ◽  
R.J. Lewandowski ◽  
R.A. Omary ◽  
A.C. Larson
Keyword(s):  
Hepatocellular Carcinoma ◽  
Medical Student ◽  
Iron Oxide ◽  
Natural Killer ◽  
Rat Model ◽  
Superparamagnetic Iron Oxide ◽  
Medical Student Research ◽  
Research Award ◽  
Natural Killer Lymphocytes ◽  
Efficacy Studies

scholarly journals Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Shuohui Yang ◽  
Jiang Lin ◽  
Fang Lu ◽  
Zhihong Han ◽  
Caixia Fu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Superparamagnetic Iron Oxide ◽  
Treated Group ◽  
Vessel Density ◽  
Susceptibility Weighted Imaging ◽  
Sorafenib Treatment ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Novel Biomarkers ◽  
And Control

We investigated effectiveness of ultrasmall superparamagnetic iron oxide enhanced susceptibility weighted imaging (USPIO-enhanced SWI) and mean vessel density imaging (Q) in monitoring antiangiogenic effects of Sorafenib on orthotopic hepatocellular carcinoma (HCC). Thirty-five HCC xenografts were established. USPIO-enhanced SWI and Q were performed on a 1.5 T MR scanner at baseline, 7, 14, and 21 days after Sorafenib treatment. Intratumoral susceptibility signal intensity (ITSS) and Q were serially measured and compared between the treated (n = 15) and control groups (n = 15). Both ITSS and Q were significantly lower in the treated group at each time point (P < 0.05). Measurements in the treated group showed that ITSS persisted at 7 days (P = 0.669) and increased at 14 and 21 days (P < 0.05), while Q significantly declined at 7 days (P = 0.028) and gradually increased at 14 and 21 days. In the treated group, significant correlation was found between Q and histologic microvessel density (MVD) (r = 0.753, P < 0.001), and ITSS correlated well with MVD (r = 0.742, P = 0.002) after excluding the data from baseline. This study demonstrated that USPIO-enhanced SWI and Q could provide novel biomarkers for evaluating antiangiogenic effects of Sorafenib on HCC.

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