Detachable string magnetically controlled capsule endoscopy for detecting high-risk varices in compensated advanced chronic liver disease (CHESS1801): A prospective multicenter study

Hepatitis A (HAV) infection is caused by the hepatitis A virus which is transmitted through the fecal-oral route. Life long protective antibodies are present after infection. The number of cases of adult hepatitis A has progressively been increasing during the last several decades in Bangladesh. In addition, the pattern of age-specific seroprevalence of anti-HAV has changed with economic growth. The prevalence of anti-HAV in 20-40 year age range has declined rapidly during the last 3 decades. As a result, this age groups has a high risk for HAV infection and clinically overt hepatitis A is increasing in adolescents and adult. The aim of the present study were to assess whether the proportion of adults with acute HAV infection has been increasing over the years and analyze the seroprevalence of immunoglobulin M(IgM) anti- HAV antibodies in young adults below the age of 20 years as well as in cases of chronic liver disease. Sera collected from 530 patients with acute and chronic liver disease attends the Somorita Hospital Ltd. during the previous 2 years and 6 months (Jan. 2008- Jun. 2010) were tested for various serological markers of acute and chronic hepatitis. In addition, 530 normal healthy attendants of the patients above the age of 20 years were tested for IgM anti-HAV as controls. Of 530 patients with acute hepatitis (13.42%) were positive for immunoglobulin M. The patients who were IgM anti-HAV negative were found to be hepatitis B (106 patients), hepatitis C, (10 patients), hepatitis E (150 patients) and unclassified (273 patients). Although the frequency of HAV infection among young adult (< 20 age) had increased (33.33% to 42.35%) in the 2 years and 6 months period, the frequency of HAV infection among adults had also increased (15.38% to 28.13%) during the same period. This study should be helpful for the identification of high risk population for vaccination of hepatitis A. DOI: http://dx.doi.org/10.3329/bjsir.v47i3.13065 Bangladesh J. Sci. Ind. Res. 47(3), 309-312 2012

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Adherence to Hepatocellular Carcinoma Surveillance and Perceived Barriers Among High-Risk Chronic Liver Disease Patients in Yunnan, China

Cancer Management and Research ◽

10.2147/cmar.s259195 ◽

2020 ◽

Vol Volume 12 ◽

pp. 6209-6220

Author(s):

Jingyi Dai ◽

Jun Zhao ◽

Yingrong Du ◽

Lin Zhuang ◽

Edward B McNeil ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Disease ◽

High Risk ◽

Chronic Liver Disease ◽

Chronic Liver ◽

Perceived Barriers ◽

Hepatocellular Carcinoma Surveillance

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Application of shear wave elastography for Baveno VI criteria and combined model using spleen stiffness measurement to rule out high-risk varices in advanced chronic liver disease.

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2019.07.290 ◽

2019 ◽

Vol 45 ◽

pp. S86

Author(s):

Young Seo Cho ◽

Yongsoo Kim ◽

On Koo Cho

Keyword(s):

Liver Disease ◽

High Risk ◽

Chronic Liver Disease ◽

Shear Wave ◽

Shear Wave Elastography ◽

Chronic Liver ◽

Combined Model ◽

Stiffness Measurement ◽

Spleen Stiffness ◽

Rule Out

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ADULTS WITH TETRALOGY OF FALLOT ARE AT HIGH RISK FOR CHRONIC LIVER DISEASE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(11)60434-8 ◽

2011 ◽

Vol 57 (14) ◽

pp. E434

Author(s):

Walter Li ◽

Nicholas Pietris ◽

Pramod Mistry ◽

George Lui ◽

Jeremy Asnes ◽

...

Keyword(s):

Liver Disease ◽

High Risk ◽

Chronic Liver Disease ◽

Tetralogy Of Fallot ◽

Chronic Liver

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Characteristics of opioid prescribing to outpatients with chronic liver diseases: A call for action

PLoS ONE ◽

10.1371/journal.pone.0261377 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0261377

Author(s):

Olufunso M. Agbalajobi ◽

Theresa Gmelin ◽

Andrew M. Moon ◽

Wheytnie Alexandre ◽

Grace Zhang ◽

...

Keyword(s):

Liver Disease ◽

High Risk ◽

Chronic Liver Disease ◽

Medical Center ◽

Chronic Liver ◽

Prescribing Patterns ◽

Prescription Opioid ◽

Alcoholic Fatty Liver ◽

Opioid Prescribing ◽

One Year

Background Chronic liver disease (CLD) is among the strongest risk factors for adverse prescription opioid-related events. Yet, the current prevalence and factors associated with high-risk opioid prescribing in patients with chronic liver disease (CLD) remain unclear, making it challenging to address opioid safety in this population. Therefore, we aimed to characterize opioid prescribing patterns among patients with CLD. Methods This retrospective cohort study included patients with CLD identified at a single medical center and followed for one year from 10/1/2015-9/30/2016. Multivariable, multinomial regression was used identify the patient characteristics, including demographics, medical conditions, and liver-related factors, that were associated with opioid prescriptions and high-risk prescriptions (≥90mg morphine equivalents per day [MME/day] or co-prescribed with benzodiazepines). Results Nearly half (47%) of 12,425 patients with CLD were prescribed opioids over a one-year period, with 17% of these receiving high-risk prescriptions. The baseline factors significantly associated with high-risk opioid prescriptions included female gender (adjusted incident rate ratio, AIRR = 1.32, 95% CI = 1.14–1.53), Medicaid insurance (AIRR = 1.68, 95% CI = 1.36–2.06), cirrhosis (AIRR = 1.22, 95% CI = 1.04–1.43) and baseline chronic pain (AIRR = 3.40, 95% CI = 2.94–4.01), depression (AIRR = 1.93, 95% CI = 1.60–2.32), anxiety (AIRR = 1.84, 95% CI = 1.53–2.22), substance use disorder (AIRR = 2.16, 95% CI = 1.67–2.79), and Charlson comorbidity score (AIRR = 1.27, 95% CI = 1.22–1.32). Non-alcoholic fatty liver disease was associated with decreased high-risk opioid prescriptions (AIRR = 0.56, 95% CI = 0.47–0.66). Conclusion Opioid medications continue to be prescribed to nearly half of patients with CLD, despite efforts to curtail opioid prescribing due to known adverse events in this population.

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