HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24

2006 ◽  
Vol 30 (8) ◽  
pp. 1005-1011 ◽  
Author(s):  
Takayuki Ikezoe ◽  
Kentaro Bandobashi ◽  
Yang Yang ◽  
Seisho Takeuchi ◽  
Nobuo Sekiguchi ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Myeloid Leukemia ◽  
Growth Arrest ◽  
Leukemia Cells ◽  
Down Regulation ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Hiv 1 ◽  
Induce Growth Arrest

Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid

Blood ◽  
2001 ◽  
Vol 97 (8) ◽  
pp. 2449-2456 ◽  
Author(s):  
Pierre G. Lutz ◽  
Anne Houzel-Charavel ◽  
Christel Moog-Lutz ◽  
Yvon E. Cayre
Keyword(s):  
Retinoic Acid ◽  
Myeloid Leukemia ◽  
Target Genes ◽  
Growth Arrest ◽  
Constitutive Expression ◽  
Myeloid Cell ◽  
Leukemia Cells ◽  
Down Regulation ◽  
Novel Target ◽  
Stimulating Factor

Abstract A pivotal role has been assigned to Myb in the control of myeloid cell growth. Although Myb is a target of retinoic acid, little is known about the mechanisms by which it may contribute to induced growth arrest in leukemia cells. Indeed, few Myb target genes are known to be linked to proliferation. Myeloblastin is involved in the control of proliferation in myeloid leukemia cells. It is expressed early during hematopoiesis and is a granulocyte colony-stimulating factor–responsive gene. Myeloblastin can confer factor-independent growth to hematopoietic cells, an early step in leukemia transformation. The myeloblastin promoter contains PU.1, C/EBP, and Myb binding sites, each of which are critical for constitutive expression in myeloid cells. Inhibition of myeloblastin expression in leukemia cells growth-arrested by retinoic acid is demonstrated to depend on Myb down-regulation. Myb is shown to induce myeloblastin expression and abolish its down-regulation by retinoic acid. Altogether, the data offer a clue as to how a myeloid-specific transcriptional machinery can be accessible to regulation by retinoic acid and point to myeloblastin as a novel target of Myb. This link between Myb and myeloblastin suggests a previously nonidentified Myb pathway through which growth arrest is induced by retinoic acid in myeloid leukemia cells.

scholarly journals MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis

2011 ◽  
Vol 71 (19) ◽  
pp. 6230-6239 ◽  
Author(s):  
Elzbieta Gocek ◽  
Xuening Wang ◽  
Xiuping Liu ◽  
Chang-Gong Liu ◽  
George P. Studzinski
Keyword(s):  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Induced Apoptosis

scholarly journals MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3

Cell Cycle ◽  
2009 ◽  
Vol 8 (5) ◽  
pp. 736-741 ◽  
Author(s):  
Xuening Wang ◽  
Elzbieta Gocek ◽  
Chang-Gong Liu ◽  
George P. Studzinski
Keyword(s):  
Myeloid Leukemia ◽  
Leukemia Cells ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3
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