The FLT3 internal tandem duplication mutation at disease diagnosis is a negative prognostic factor in myelodysplastic syndrome patients

2022 ◽  
pp. 106790
Author(s):  
Ritsu Sumiyoshi ◽  
Haruko Tashiro ◽  
Ryosuke Shirasaki ◽  
Takuji Matsuo ◽  
Tadashi Yamamoto ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Myelodysplastic Syndrome ◽  
Tandem Duplication ◽  
Disease Diagnosis ◽  
Internal Tandem Duplication ◽  
Negative Prognostic Factor ◽  
Flt3 Internal Tandem Duplication

FLT3 internal tandem duplication during myelodysplastic syndrome follow-up: a marker of transformation to acute myeloid leukemia

2008 ◽  
Vol 183 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Ronald Feitosa Pinheiro ◽  
Eloisa de Sá Moreira ◽  
Maria Regina Régis Silva ◽  
Fernando Lopes Alberto ◽  
Maria de Lourdes L.F. Chauffaille
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Tandem Duplication ◽  
Internal Tandem Duplication ◽  
Flt3 Internal Tandem Duplication ◽  
Acute Myeloid

AML1 Mutation and FLT3-internal Tandem Duplication in Leukemia Transformed From Myelodysplastic Syndrome

2007 ◽  
Vol 29 (9) ◽  
pp. 666-667 ◽  
Author(s):  
Akira Shimada ◽  
Takeshi Taketani ◽  
Akira Kikuchi ◽  
Ryoji Hanada ◽  
Hiroshi Arakawa ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Tandem Duplication ◽  
Internal Tandem Duplication ◽  
Flt3 Internal Tandem Duplication

scholarly journals AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Blood ◽  
2014 ◽  
Vol 123 (6) ◽  
pp. 905-913 ◽  
Author(s):  
Erika K. Keeton ◽  
Kristen McEachern ◽  
Keith S. Dillman ◽  
Sangeetha Palakurthi ◽  
Yichen Cao ◽  
...  
Keyword(s):  
Messenger Rna ◽  
Myeloid Leukemia ◽  
Tandem Duplication ◽  
Kinase Inhibitor ◽  
Wild Type ◽  
Internal Tandem Duplication ◽  
Rna Translation ◽  
Key Points ◽  
Messenger Rna Translation ◽  
Flt3 Internal Tandem Duplication

Key Points AZD1208 is a selective pan-Pim kinase inhibitor with efficacy in AML cells, xenografts, and Flt3-internal tandem duplication or Flt3 wild-type patient samples. AML cell growth inhibition is associated with suppression of p70S6K, 4EBP1 phosphorylation, and messenger RNA translation.

FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype

2007 ◽  
Vol 42 (3) ◽  
pp. 250 ◽  
Author(s):  
Sang-Ho Kim ◽  
Yeo-Kyeoung Kim ◽  
Il-Kwon Lee ◽  
Deog-Yeon Jo ◽  
Jong-Ho Won ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Tandem Duplication ◽  
Normal Karyotype ◽  
Internal Tandem Duplication ◽  
Flt3 Internal Tandem Duplication ◽  
Acute Myeloid
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