Sphingosine 1-phosphate promotes mesenchymal stem cell-mediated cardioprotection against myocardial infarction via ERK1/2-MMP-9 and Akt signaling axis

Life Sciences ◽  
2018 ◽  
Vol 215 ◽  
pp. 31-42 ◽  
Author(s):  
Ruirui Chen ◽  
Xiqiang Cai ◽  
Jing Liu ◽  
Baobao Bai ◽  
Xue Li
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Akt Signaling ◽  
Signaling Axis ◽  
Sphingosine 1 Phosphate

scholarly journals Intramyocardial Delivery of Mesenchymal Stem Cell-Seeded Hydrogel Preserves Cardiac Function and Attenuates Ventricular Remodeling after Myocardial Infarction

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51991 ◽  
Author(s):  
Eva Mathieu ◽  
Guillaume Lamirault ◽  
Claire Toquet ◽  
Pierre Lhommet ◽  
Emilie Rederstorff ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cardiac Function ◽  
Ventricular Remodeling ◽  
Intramyocardial Delivery

scholarly journals Monitoring bone marrow-originated mesenchymal stem cell traffic to myocardial infarction sites using magnetic resonance imaging

2011 ◽  
Vol 65 (5) ◽  
pp. 1430-1436 ◽  
Author(s):  
Yidong Yang ◽  
Autumn Schumacher ◽  
Yuhui Yang ◽  
Jimei Liu ◽  
Xingming Shi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Bone Marrow ◽  
Stem Cell ◽  
Magnetic Resonance ◽  
Mesenchymal Stem Cell ◽  
Resonance Imaging

scholarly journals Application and Progress of Combined Mesenchymal Stem Cell Transplantation in the Treatment of Ischemic Cardiomyopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ping Hua ◽  
Jian-Yang Liu ◽  
Jun Tao ◽  
Song-Ran Yang
Keyword(s):  
Myocardial Infarction ◽  
Tissue Engineering ◽  
Stem Cell ◽  
Treatment Outcome ◽  
Survival Rate ◽  
Mesenchymal Stem Cell ◽  
Ischemic Cardiomyopathy ◽  
Mesenchymal Stem Cell Transplantation ◽  
Hypoxia Preconditioning ◽  
Impact On Treatment

Treatment of ischemic cardiomyopathy caused by myocardial infarction (MI) using mesenchymal stem cell (MSC) transplantation is a widely researched field, with promising clinical application. However, the low survival rate of transplanted cells has a severe impact on treatment outcome. Currently, research is focused on investigating the strategy of combining genetic engineering, tissue engineering materials, and drug/hypoxia preconditioning to improve ischemic cardiomyopathy treatment outcome using MSC transplantation treatment (MSCTT). This review discusses the application and progress of these techniques.

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