Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism

Life Sciences ◽  
2019 ◽  
Vol 227 ◽  
pp. 30-38 ◽  
Author(s):  
Anand Thirupathi ◽  
Yan-Zhong Chang
Keyword(s):  
Cancer Survival ◽  
Survival Mechanism

Role of autophagy as trophoblast survival mechanism in preeclampsia

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 278-279
Author(s):  
Martina Hutabarat ◽  
Noroyono Wibowo ◽  
Berthold Huppertz
Keyword(s):  
Survival Mechanism

scholarly journals Lung cancer survival trend in Umbria, Italy, 1994-2016: preliminary results

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Ostorero ◽  
A Gili ◽  
S Violi ◽  
F Stracci
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Tobacco Smoking ◽  
Cancer Survival ◽  
Cancer Control ◽  
Mortality Trends ◽  
Incidence And Mortality ◽  
New Treatments ◽  
Lung Cancer Survival

Abstract Background Lung cancer is the second most common cancer worldwide and the leading cause of death for cancer (18.4%). During the last 30 years, lung cancer incidence and mortality increased in women and decreased in men, because of tobacco smoking exposure. Population survival trend reflects both the influence of disease severity at diagnosis and treatment effectiveness. Some studies reported an increase in global lung cancer survival and linked it to new treatment options. However, change in the overall survival may also reflect a shift towards morphologies with more favorable prognosis. We analyzed overall and morphology specific survival trends for lung cancer to gain insight on the role of new treatments and changing exposures. Methods We analyzed lung cancer 1 y-survival and 3 y-survival after diagnosis in Umbria (890'000 inhabitants) in the period 1994-2016. Population-based data were obtained from the Umbrian Cancer Registry (RTUP), Italy. We estimated relative net survival (Pohar-Perme approach) stratified both for sex and histotype (NSCLC, SCLC, NOS), considering six diagnostic periods from 1994 to 2016 (4 years for period, except 3 in the last one) for 5'268 lung cancer cases (26% women). Results Overall survival by gender resulted 40,5% (1y) and 16.5% (3y) in men, 47,3% (1y) and 23,2% (3y) in women. NSCLC survival increased in women during the period 1994-2016 from 41% to 53% (1y) and from 23% to 33% (3y), and remained unchanged in men. SCLC 3 year-survival did not change significantly neither in women nor in men. Conclusions We did not observe a significant increase in lung cancer survival over a 25 years period. We observed a significant increase in survival probabilities for NSCLC among women only. Thus, our data don't confirm a major role of new treatments in improving lung cancer control. We will provide further analyses for adenocarcinoma and a comparison of incidence and mortality trends to understand the influence of exposures and treatments on survival. Key messages A general increase in lung cancer survival, as could be expected after the introduction of new highly effective treatments is not present in western countries. Reducing exposure to tobacco smoking and environmental pollution remain the main intervention to improve lung cancer control.

scholarly journals SYK Allelic Loss and the Role of Syk-Regulated Genes in Breast Cancer Survival

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87610 ◽  
Author(s):  
Jan Blancato ◽  
Ashley Graves ◽  
Banafsheh Rashidi ◽  
Maria Moroni ◽  
Leopold Tchobe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Allelic Loss

scholarly journals Upregulated Autophagy in Calcific Aortic Valve Stenosis Confers Protection of Valvular Interstitial Cells

2019 ◽  
Vol 20 (6) ◽  
pp. 1486 ◽  
Author(s):  
Miguel Carracedo ◽  
Oscar Persson ◽  
Peter Saliba-Gustafsson ◽  
Gonzalo Artiach ◽  
Ewa Ehrenborg ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Stenosis ◽  
Interstitial Cells ◽  
Left Ventricular ◽  
Autophagic Flux ◽  
Valvular Interstitial Cells ◽  
Survival Mechanism ◽  
Calcified Tissue ◽  
Left Ventricular Outflow

Autophagy serves as a cell survival mechanism which becomes dysregulated under pathological conditions and aging. Aortic valve thickening and calcification causing left ventricular outflow obstruction is known as calcific aortic valve stenosis (CAVS). CAVS is a chronic and progressive disease which increases in incidence and severity with age. Currently, no medical treatment exists for CAVS, and the role of autophagy in the disease remains largely unexplored. To further understand the role of autophagy in the progression of CAVS, we analyzed expression of key autophagy genes in healthy, thickened, and calcified valve tissue from 55 patients, and compared them with nine patients without significant CAVS, undergoing surgery for aortic regurgitation (AR). This revealed a upregulation in autophagy exclusively in the calcified tissue of CAVS patients. This difference in autophagy between CAVS and AR was explored by LC3 lipidation in valvular interstitial cells (VICs), revealing an upregulation in autophagic flux in CAVS patients. Inhibition of autophagy by bafilomycin-A1 led to a decrease in VIC survival. Finally, treatment of VICs with high phosphate led to an increase in autophagic activity. In conclusion, our data suggests that autophagy is upregulated in the calcified tissue of CAVS, serving as a compensatory and pro-survival mechanism.

Inflammatory Breast Cancer Survival: The Role of Obesity and Menopausal Status at Diagnosis

2000 ◽  
Vol 64 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Shine Chang ◽  
Julie R. Alderfer ◽  
Lina Asmar ◽  
Aman U. Buzdar
Keyword(s):  
Breast Cancer ◽  
Inflammatory Breast Cancer ◽  
Cancer Survival ◽  
Menopausal Status ◽  
Breast Cancer Survival

scholarly journals Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Kate M Peters ◽  
Stacey L Edwards ◽  
Shalima S Nair ◽  
Juliet D French ◽  
Peter J Bailey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Epigenetic Events

The role of glutathione-related genes in lung cancer survival

Lung Cancer ◽  
1999 ◽  
Vol 25 ◽  
pp. S14
Author(s):  
P. Yang ◽  
A. Yokomizo ◽  
R. Marks ◽  
T. Lesnick ◽  
J. Sloan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Survival ◽  
Lung Cancer Survival
Sign in / Sign up

Export Citation Format

Share Document