Immunoreactive definition of TNF- α, HIF-1 α, Kir6.2, Kir3.1 and M2 muscarinic receptor for cardiac and pancreatic tissues in a mouse model for type 1 diabetes

Life Sciences ◽  
2021 ◽  
pp. 119886
Author(s):  
Aslı Okan ◽  
Züleyha Doğanyiğit ◽  
Ece Eroğlu ◽  
Enes Akyüz ◽  
Necdet Demir
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Muscarinic Receptor ◽  
Tnf Α ◽  
M2 Muscarinic Receptor ◽  
Definition Of

Absence of CXCL10 prolongs islet graft survival in an autoimmune mouse model for Type 1 Diabetes

2015 ◽  
Vol 10 (04) ◽  
Author(s):  
C Bender ◽  
S Christen ◽  
E Hintermann ◽  
U Christen
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Graft Survival ◽  
Islet Graft ◽  
Autoimmune Mouse

scholarly journals Differential Expression of Inflammatory Markers in Hypoglycemia Unawareness Associated with Type 1 Diabetes: A Case Report

2020 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Yousef Al Zoubi ◽  
Bashair M. Mussa ◽  
Ankita Srivastava ◽  
Abdul Khader Mohammed ◽  
Elamin Abdelgadir ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Case Report ◽  
Differential Expression ◽  
Insulin Pump ◽  
Mrna Level ◽  
Insulin Injection ◽  
Hypoglycemia Unawareness ◽  
Tnf Α ◽  
Ifn Γ

The recurrence of hypoglycemic episodes leads to attenuation of the normal counter-regulatory mechanisms that are controlled by the hypothalamus, which results in hypoglycemia unawareness (HU). In this case report, we described for the first time the differential expression of TNF-α, IL-1β, IL-6, and IFN-γ in a blood sample that was taken from a 27-year-old patient with type 1 diabetes mellitus (T1DM) who was diagnosed with HU. The anti-diabetic regimen is currently based on insulin injection, but the patient is planning to start the use of an insulin pump to have better control of glucose levels. Our results showed a trend toward an increase in the expression of IL-1β, IL-6, and IFN-γ in T1DM patient with HU. However, the mRNA level of TNF-α showed a significant decrease. These observations suggest that systemic inflammation could be an underlying cause of HU.

scholarly journals TLR9-Deficiency in B Cells Promotes Immune Tolerance via IL-10 in a Type 1 Diabetes Mouse Model

Diabetes ◽  
2020 ◽  
pp. db200373
Author(s):  
Sha Sha ◽  
James A Pearson ◽  
Jian Peng ◽  
Youjia Hu ◽  
Juan Huang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
B Cells ◽  
Mouse Model ◽  
Immune Tolerance ◽  
Diabetes Mouse

Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism

2021 ◽  
pp. 108710
Author(s):  
Huifeng Wang ◽  
Qingjun Zhou ◽  
Luqin Wan ◽  
Menglong Guo ◽  
Chen Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Potential Mechanism ◽  
Lipidomic Analysis ◽  
Meibomian Glands ◽  
Diabetes Mouse

scholarly journals Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model

2016 ◽  
Vol 7 ◽  
Author(s):  
Elin Malek Abrahimians ◽  
Luc Vander Elst ◽  
Vincent A. Carlier ◽  
Jean-Marie Saint-Remy
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Nod Mouse

scholarly journals Hyperglycemia-Induced O-GlcNAcylation and Truncation of 4E-BP1 Protein in Liver of a Mouse Model of Type 1 Diabetes

2011 ◽  
Vol 286 (39) ◽  
pp. 34286-34297 ◽  
Author(s):  
Michael D. Dennis ◽  
Tabitha L. Schrufer ◽  
Sarah K. Bronson ◽  
Scot R. Kimball ◽  
Leonard S. Jefferson
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model

scholarly journals (D-Ser2)Oxm[Lys38- and #947;-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes

2016 ◽  
Vol 6 (1) ◽  
pp. 1 ◽  
Author(s):  
Nupur Pathak ◽  
Nigel Irwin ◽  
Varun Pathak ◽  
Victor Gault ◽  
Peter Flatt
Keyword(s):  
Gene Expression ◽  
Type 1 Diabetes ◽  
Mouse Model

scholarly journals Diabetes-induced Changes in Mannan-binding Lectin Levels and Complement Activation in a Mouse Model of Type 1 Diabetes

2013 ◽  
Vol 77 (3) ◽  
pp. 187-194 ◽  
Author(s):  
J. A. Østergaard ◽  
M. Bjerre ◽  
F. Dagnaes-Hansen ◽  
T. K. Hansen ◽  
S. Thiel ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Complement Activation ◽  
Induced Changes ◽  
Mannan Binding Lectin ◽  
Binding Lectin
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