Association study between single nucleotide polymorphisms in candidate genes and reproduction traits in Italian Large White sows

2013 ◽  
Vol 155 (2-3) ◽  
pp. 172-179 ◽  
Author(s):  
S. Dall'Olio ◽  
L. Fontanesi ◽  
L. Buttazzoni ◽  
C. Baiocco ◽  
M. Gallo ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Association Study ◽  
Candidate Genes ◽  
Nucleotide Polymorphisms ◽  
Large White ◽  
Single Nucleotide ◽  
Reproduction Traits

scholarly journals Association Study With 33 Single-Nucleotide Polymorphisms in 11 Candidate Genes for Hypertension in Chinese

Hypertension ◽  
2006 ◽  
Vol 47 (6) ◽  
pp. 1147-1154 ◽  
Author(s):  
Dongfeng Gu ◽  
Shaoyong Su ◽  
Dongliang Ge ◽  
Shufeng Chen ◽  
Jianfeng Huang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Association Study ◽  
Candidate Genes ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Associations of fifty single nucleotide polymorphisms within candidate genes with meatness in pigs

2014 ◽  
Vol 59 (No. 5) ◽  
pp. 227-237 ◽  
Author(s):  
A. Borowska ◽  
T. Szwaczkowski ◽  
M. Koćwin-Podsiadła ◽  
S. Kamiński ◽  
A. Ruść ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Linear Model ◽  
Generalized Linear Model ◽  
Continuous Variable ◽  
Chromosome 1 ◽  
Nucleotide Polymorphisms ◽  
Entropy Analysis ◽  
Large White ◽  
Single Nucleotide

The objective of the paper was to classify 50 SNPs (from 17 chromosomes) according to their contribution to the meatness of 293 boars of two breeds (Polish Landrace and Polish Large White) using entropy analysis and standard association analysis. The collected data were classified into two groups (according to the official EUROP procedure) and used for entropy analysis. Associations of single genotypes versus their groups (located at single chromosomes) with the trait studied were estimated by the use of the Generalized Linear Model (GLM). Thus meatness was included as a continuous variable. The most important contributions have been estimated by both approaches for the following SNPs: SULT1A1:g.76G>A (SSC3), PKLR:g.384C>T (SSC4), MYOD1:c.566G>C (SSC2), TNNT3:g.153T>C (SSC2), GAA:g.38T>C (SSC12), LDLRR1:c.459A>G (SSC8), MYF6:g.255T>C (SSC5), CAS:g.499A>C (SSC2), PPARGC:c.678T>A (SSC15). Moreover, interactions among some studied loci are suggested, especially for the loci at chromosome 1.  

scholarly journals Genome-wide association study (GWAS) with productivity in Romanov sheep breed

2021 ◽  
Vol 59 (1) ◽  
pp. 71-80
Author(s):  
A. Y. Krivoruchko ◽  
O. A. Yatsyk ◽  
T. Y. Saprikina ◽  
D. D. Petukhova
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Association Study ◽  
Candidate Genes ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Elite Group ◽  
Genome Wide ◽  
Productive Traits

Genetic technologies used in breeding of small ruminants requires searching for new molecular markers of productive traits. The most effective for this is genome-wide association study (GWAS) of single nucleotide polymorphisms (SNP) with economically valuable traits. The paper presents results of study of associations of the frequency of single nucleotide polymorphisms with a rank assessment according to complex of productive traits (super-elite) in Romanov sheep using DNA biochips Ovine Infinium HD BeadChip 600K. Eleven SNPs have been found having significant correlation with the animals belonging to the “super-elite” group. Five substitutions are located in the genes introns, six are related to intergenic polymorphisms. The highest reliability of association with productivity was observed in substitution rs410516628 (р = 3,14 · 10-9) located on the 3rd chromosome. Substitution rs422028000 on 2nd chromosome differs with the fact that in the “super-elite” group it was found in 90 % of haplotypes. Polymorphisms rs411162754 (1st chromosome) and rs417281100 (10th chromosome) in our study turned out to be the rarest – only in “super-elite” group and only in a quarter of haplotypes. The genes located near the identified SNPs are mainly associated with metabolic and regulatory processes. Our study has identified several new candidate genes with polymorphism probably associated with the ranking in terms of productivity in Romanov sheep: LTBP1, KCNH8, LMX1B, ZBTB43, MSRA, CHPF, PID1 and DNER. The results obtained create a theoretical basis for further study of candidate genes affecting implementation of phenotypic traits in Romanov sheep. The revealed polymorphisms associated with the productive traits of sheep can be used in practical breeding as molecular and genetic markers for selection of parental pairs.

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