Phase Ib/II study of the pan-cyclin-dependent kinase inhibitor roniciclib in combination with chemotherapy in patients with extensive-disease small-cell lung cancer

Lung Cancer ◽

10.1016/j.lungcan.2018.04.022 ◽

2018 ◽

Vol 123 ◽

pp. 14-21 ◽

Author(s):

Byoung Chul Cho ◽

Grace K. Dy ◽

Ramaswamy Govindan ◽

Dong-Wan Kim ◽

Nathan A. Pennell ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Extensive Disease ◽

Phase Ib ◽

Cyclin Dependent Kinase Inhibitor

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P-057 Expression of the cyclin-dependent kinase inhibitor p21 is linkedto regulation of RAD51 in response to etoposide treatment of small cell lung cancer cells

Lung Cancer ◽

10.1016/s0169-5002(05)80551-3 ◽

2005 ◽

Vol 49 ◽

pp. S129

Author(s):

R. Jensen ◽

M. Spang-Thomsen ◽

L. Hansen

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Cells ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Cyclin Dependent Kinase Inhibitor ◽

Etoposide Treatment

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Potentiation of in vitro and in vivoantitumor efficacy of doxorubicin by cyclin-dependent kinase inhibitor P276-00 in human non-small cell lung cancer cells

10.1186/1471-2407-13-29 ◽

2013 ◽

Vol 13 (1) ◽

Author(s):

Maggie J Rathos ◽

Harshal Khanwalkar ◽

Kavita Joshi ◽

Sonal M Manohar ◽

Kalpana S Joshi

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Cells ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Cyclin Dependent Kinase Inhibitor

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Downregulation of XIAP and induction of apoptosis by the synthetic cyclin-dependent kinase inhibitor GW8510 in non-small cell lung cancer cells

Cancer Biology & Therapy ◽

10.4161/cbt.5.2.2316 ◽

2006 ◽

Vol 5 (2) ◽

pp. 165-170 ◽

Author(s):

Fengqin Dong ◽

Wei Guo ◽

Lidong Zhang ◽

Shuhong Wu ◽

Fuminori Teraishi ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Cells ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Cyclin Dependent Kinase Inhibitor ◽

Induction Of Apoptosis

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The cyclin-dependent kinase inhibitor p27 as a prognostic factor in advanced non-small cell lung cancer: its immunohistochemical evaluation using biopsy specimens

Lung Cancer ◽

10.1016/s0169-5002(99)00085-9 ◽

1999 ◽

Vol 26 (3) ◽

pp. 187-194 ◽

Author(s):

Shinichi Ishihara ◽

Koichi Minato ◽

Hideki Hoshino ◽

Ryusei Saito ◽

Futoshi Hara ◽

...

Keyword(s):

Lung Cancer ◽

Prognostic Factor ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Cyclin Dependent Kinase Inhibitor ◽

Biopsy Specimens

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Increased expression levels of cyclin-dependent kinase inhibitor p27 correlate with good responses to platinum-based chemotherapy in non-small cell lung cancer.

Oncology Reports ◽

10.3892/or.7.3.491 ◽

2000 ◽

Author(s):

F Oshita ◽

Y Kameda ◽

K Nishio ◽

G Tanaka ◽

K Yamada ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Expression Levels ◽

Cyclin Dependent Kinase Inhibitor ◽

Platinum Based Chemotherapy

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Randomized phase 2 study of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus erlotinib in patients with non-small cell lung cancer

Lung Cancer ◽

10.1016/j.lungcan.2013.11.020 ◽

2014 ◽

Vol 83 (2) ◽

pp. 219-223 ◽

Author(s):

Joe J. Stephenson ◽

John Nemunaitis ◽

Anil A. Joy ◽

Julie C. Martin ◽

Ying-Ming Jou ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Kinase Inhibitor ◽

Phase 2 ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Cyclin Dependent Kinase Inhibitor ◽

Phase 2 Study ◽

Randomized Phase 2

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Synergistic Anticancer Activity of Topotecan— Cyclin-Dependent Kinase Inhibitor Combinations against Drug-Resistant Small Cell Lung Cancer (SCLC) Cell Lines

Journal of Cancer Therapy ◽

10.4236/jct.2013.48a008 ◽

2013 ◽

Vol 04 (08) ◽

pp. 47-53 ◽

Author(s):

Gerhard Hamilton ◽

Ulrike Olszewski, Lukas Klameth ◽

Ernst Ulsperger ◽

Klaus Geissler

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Anticancer Activity ◽

Kinase Inhibitor ◽

Drug Resistant ◽

Cyclin Dependent Kinase ◽

Small Cell Lung ◽

Cyclin Dependent Kinase Inhibitor

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A phase Ib study to evaluate the PI3-kinase inhibitor GDC-0941 with paclitaxel (P) and carboplatin (C), with and without bevacizumab (BEV), in patients with advanced non-small cell lung cancer (NSCLC).

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.3044 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 3044-3044 ◽

Author(s):

B. Besse ◽

J. Soria ◽

C. Gomez-Roca ◽

J. A. Ware ◽

A. A. Adjei ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Small Cell Lung ◽

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Safety, tolerability, and pharmacokinetics of simotinib, a novel specific EGFR tyrosine kinase inhibitor, in patients with advanced non-small cell lung cancer: results of a phase Ib trial

Cancer Management and Research ◽

10.2147/cmar.s189626 ◽

2019 ◽

Vol Volume 11 ◽

pp. 4449-4459

Author(s):

Xing-sheng Hu ◽

Xiao-hong Han ◽

Sheng Yang ◽

Ning Li ◽

Lin Wang ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Tyrosine Kinase Inhibitor ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Small Cell Lung ◽

Egfr Tyrosine Kinase Inhibitor ◽

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New drugs for chemotherapy-naive patients with extensive-disease small cell lung cancer

Seminars in Oncology ◽

10.1053/sonc.2001.25742 ◽

2001 ◽

Vol 28 (2 Suppl 4) ◽

pp. 27-29 ◽

Author(s):

David S. Ettinger

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

New Drugs ◽

Small Cell Lung ◽

Extensive Disease

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