Nanofibrous scaffolds from chitosan and poly(caprolactone) for excision wound healing application in canine model

Injuries and wounds are any sorts of damage to the skin or subcutaneous tissue. Usually, any wounds of such sorts are self-healed. Sometimes, there may be a delay in healing, and that delay is caused due to the functional delays in various processes of wound healing. All the Ficus plants show similar activities like the antioxidant, anti-inflammatory and wound healing properties 7including skin conditions like ulcers and rheumatism. The anthelmintic property and immunomodulatory are also seen. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. All the extracts showed a better healing ability, but the extract of FBO-100 showed the highest activity followed by FMO followed by FHO and finally the FRO. Overall, the activity of the extract ointment was comparable and was significant compared to the standard drug ointment. The wound closure of the extract ointment treated groups were better and were completed in 12 days, and the activity was more than 96%. The herbal extracts of the same family of Ficus in different plants were investigated for the wound healing activity in the excision wound method, and the extracts showed significant activity compared to the drug. The plants of microcarpa, benghalensis, religiosa and hispida are compared for the activity, and the order showed for the activity was FBO>FMO>FHO>FRO.

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Fabrication and Assessment of Gentamicin Loaded Electrospun Nanofibrous Scaffolds as a Quick Wound Healing Dressing Material

Current Nanoscience ◽

10.2174/1573413710666141003221954 ◽

2015 ◽

Vol 11 (2) ◽

pp. 222-228 ◽

Cited By ~ 6

Author(s):

Charu Dwivedi ◽

Himanshu Pandey ◽

Avinash Pandey ◽

Pramod Ramteke

Keyword(s):

Wound Healing ◽

Nanofibrous Scaffolds

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Nanofibrous scaffolds of carboxymethyl guargum potentiated with reduced graphene oxide for wound healing applications

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.121035 ◽

2021 ◽

pp. 121035

Author(s):

Arun Koyyada ◽

Prabhakar Orsu

Keyword(s):

Wound Healing ◽

Graphene Oxide ◽

Reduced Graphene Oxide ◽

Nanofibrous Scaffolds ◽

Reduced Graphene

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EFFECT OF HEALOL OIL ON WOUND HEALING IN WISTAR RATS: A NOVEL STUDY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i3.23223 ◽

2018 ◽

Vol 11 (3) ◽

pp. 152

Author(s):

Sujith V ◽

Poornima G ◽

Balaji O ◽

Bairy Kl ◽

Praveen K ◽

...

Keyword(s):

Wound Healing ◽

Wistar Rats ◽

Chronic Wounds ◽

Statistical Significance ◽

Silver Sulfadiazine ◽

Histopathological Analysis ◽

Burn Wound ◽

Excision Wound ◽

Burn Wounds ◽

Wound Model

Objective: Wound healing is a complex process, and various plant extracts have been used to study the effect of medicinal plants on wound healing. Healol oil is used in some tribal areas for ulcer healing and treatment of burn wounds. There are no animal studies done so far using healol oil to find out its role in the treatment of wounds. Hence, the aim of our study is to find the effect of healol oil in excision as well burn wounds in Wistar rats.Methods: Thirty-six Wistar rats were used, 18 rats in excision wound model and remaining in burn wound model. Each model consists of three groups of six rats each. Povidone-iodine was used as a standard control in excision wound model and silver sulfadiazine was used as a standard control in burn wound model. Healol oil was used as test drug in both the models. Period of epithelization and wound contracture rates were analyzed. Histopathological analysis of the skin tissue was done. One-way analysis of variance was used followed by Tukey’s post hoc test for statistical analysis using SPSS version 23 software, P value of <0.05 was taken as statistical significance.Results: Both standard and test groups showed significantly faster wound healing (p<0.001) compared to control rats treated with paraffin wax in both the models. In excision model standard povidone was significantly (p<0.001) better compared to healol oil whereas in burn model, silver sulfadiazine and healol oil showed comparable results with respect to period of epithelization without statistical significance (p>0.05).Conclusion: Wound healing property of healol oil is proved, and further clinical trial can be done to find out the effect of healol oil on chronic wounds due to various etiologies.

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PLA Nanofibrous Scaffolds for Full Thickness Wound Healing

Problems of Cryobiology and Cryomedicine ◽

10.15407/cryo28.01.069 ◽

2018 ◽

Vol 28 (1) ◽

pp. 069-073

Author(s):

Maksym V. Pogorielov ◽

◽

Volodymyr N. Deineka ◽

R. G. Vasyliev ◽

D. A. Zubov ◽

...

Keyword(s):

Wound Healing ◽

Full Thickness ◽

Nanofibrous Scaffolds ◽

Full Thickness Wound

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EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII (A. DC.) IN WISTAR ALBINO RATS

Kongunadu Research Journal ◽

10.26524/krj17 ◽

2014 ◽

Vol 1 (1) ◽

pp. 73-77

Author(s):

Uma Maheswari P ◽

Shalimol A ◽

Arumugasamy A ◽

Udhaya Sankar M.R

Keyword(s):

Wound Healing ◽

Dry Weight ◽

Wound Contraction ◽

Albino Rats ◽

Standard Drug ◽

Excision Wound ◽

Wound Model ◽

Wistar Albino Rats ◽

Incision Wound ◽

Wound Healing Activity

The present experimental study was designed to evaluate the wound healing activity of methanolic extract of Smilax wightii A. DC. on incision and excision wound models in Wistar albino rats. The parameters studied were wound breaking strength, wound contraction area, epithelialization period, granulation tissuewet, dry weight and hydroxyproline content in incision wound model, percentage of wound contraction and period of epithelialization in excision wound model. The rats were administered topically with 100mg/kg b.wt. (low dosage), 200mg/kg b.wt. (moderate dosage) and 500mg/kg b.wt. (high dosage) of methanolicextract of Smilax wightii (MESW). The activity of the extract treated groups were compared with that of the control 1% Spirit. Framycetin sulphate 0.2% w/w was used as the standard drug. In incision wound model, there was a significant increase in the wound breaking strength in all the experimental groups treated withMESW than that of the control. Similarly, significant (P<0.001) decrease in wound contraction area and period of epithelialization were also observed in the test group animals treated with MESW and the standard drug treated groups when compared to that of the control. , a significant increase was observed in granulation tissue wet and dry weight and hydroxyproline content in the test groups treated with MESW compared to the control. In exicision wound model, there was a significant increase (P<0.01) in the percentage of wound contraction and decrease in period of epithelialization in the experimental groups treated with 200mg/kgb.wt. (moderate dosage) and 500mg/kgb.wt (high dosage) of MESW. The extract treated groups showed significant improvement in all the wound healing parameters of incision, and excision wound models.

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