scholarly journals Multiscale model of the human cardiovascular system: Description of heart failure and comparison of contractility indices

2017 ◽  
Vol 284 ◽  
pp. 71-79 ◽  
Author(s):  
S. Kosta ◽  
J. Negroni ◽  
E. Lascano ◽  
P.C. Dauby
Keyword(s):  
Heart Failure ◽  
Cardiovascular System ◽  
Multiscale Model ◽  
System Description ◽  
Human Cardiovascular System ◽  
Contractility Indices

scholarly journals Impact of Respiratory Fluctuation on Hemodynamics in Human Cardiovascular System: A 0-1D Multiscale Model

Fluids ◽  
2022 ◽  
Vol 7 (1) ◽  
pp. 28
Author(s):  
Ruichen Li ◽  
Koichi Sughimoto ◽  
Xiancheng Zhang ◽  
Sirui Wang ◽  
Yuto Hiraki ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Pressure Fluctuations ◽  
Intrathoracic Pressure ◽  
Multiscale Model ◽  
Hemodynamic Instability ◽  
Flow Rates ◽  
System A ◽  
Hemodynamic Model ◽  
Human Cardiovascular System ◽  
The Individual

To explore hemodynamic interaction between the human respiratory system (RS) and cardiovascular system (CVS), here we propose an integrated computational model to predict the CVS hemodynamics with consideration of the respiratory fluctuation (RF). A submodule of the intrathoracic pressure (ITP) adjustment is developed and incorporated in a 0-1D multiscale hemodynamic model of the CVS specified for infant, adolescent, and adult individuals. The model is verified to enable reasonable estimation of the blood pressure waveforms accounting for the RF-induced pressure fluctuations in comparison with clinical data. The results show that the negative ITP caused by respiration increases the blood flow rates in superior and inferior vena cavae; the deep breathing improves the venous return in adolescents but has less influence on infants. It is found that a marked reduction in ITP under pathological conditions can excessively increase the flow rates in cavae independent of the individual ages, which may cause the hemodynamic instability and hence increase the risk of heart failure. Our results indicate that the present 0-1D multiscale CVS model incorporated with the RF effect is capable of providing a useful and effective tool to explore the physiological and pathological mechanisms in association with cardiopulmonary interactions and their clinical applications.

Bifurcation in a Simple Model of the Cardiovascular System

2000 ◽  
Vol 39 (02) ◽  
pp. 118-121 ◽  
Author(s):  
S. Akselrod ◽  
S. Eyal
Keyword(s):  
Nonlinear Dynamics ◽  
Blood Pressure ◽  
Heart Rate ◽  
Fixed Point ◽  
Cardiovascular System ◽  
Modified Model ◽  
Mayer Waves ◽  
Sustained Oscillations ◽  
Human Cardiovascular System ◽  
Physiological Values

Abstract:A simple nonlinear beat-to-beat model of the human cardiovascular system has been studied. The model, introduced by DeBoer et al. was a simplified linearized version. We present a modified model which allows to investigate the nonlinear dynamics of the cardiovascular system. We found that an increase in the -sympathetic gain, via a Hopf bifurcation, leads to sustained oscillations both in heart rate and blood pressure variables at about 0.1 Hz (Mayer waves). Similar oscillations were observed when increasing the -sympathetic gain or decreasing the vagal gain. Further changes of the gains, even beyond reasonable physiological values, did not reveal another bifurcation. The dynamics observed were thus either fixed point or limit cycle. Introducing respiration into the model showed entrainment between the respiration frequency and the Mayer waves.

Computer assisted instruction for therapy of heart failure based on simulation of cardiovascular system

1987 ◽  
Vol 9 (1) ◽  
pp. 57-61
Author(s):  
Toshiro Sato ◽  
Akihiro Takeuchi ◽  
Jun Yamagami ◽  
Hareaki Yamamoto ◽  
Shigeaki Akiyama ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular System ◽  
Computer Assisted Instruction ◽  
Computer Assisted ◽  
Assisted Instruction

scholarly journals Weighing in on heart failure: the potential impact of bariatric surgery

2021 ◽  
Author(s):  
Tanuka Datta ◽  
Andrew J. Lee ◽  
Rachel Cain ◽  
Melissa McCarey ◽  
David J. Whellan
Keyword(s):  
Heart Failure ◽  
Bariatric Surgery ◽  
Weight Loss ◽  
Cardiovascular System ◽  
Economic Burden ◽  
Treatment Strategies ◽  
It Impacts ◽  
Potential Impact ◽  
The Individual ◽  
Physiologic System

AbstractObesity is a growing worldwide epidemic with significant economic burden that carries with it impacts on every physiologic system including the cardiovascular system. Specifically, the risk of heart failure has been shown to increase dramatically in obese individuals. The purpose of this review is to provide background on the individual burdens of heart failure and obesity, followed by exploring proposed physiologic mechanisms that interconnect these conditions, and furthermore introduce treatment strategies for weight loss focusing on bariatric surgery. Review of the existing literature on patients with obesity and heart failure who have undergone bariatric surgery is presented, compared, and contrasted.

scholarly journals Evaluating the Hemodynamical Response of a Cardiovascular System under Support of a Continuous Flow Left Ventricular Assist Device via Numerical Modeling and Simulations

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Selim Bozkurt ◽  
Koray K. Safak
Keyword(s):  
Heart Failure ◽  
Cardiovascular System ◽  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Continuous Flow ◽  
Left Ventricular ◽  
Circulatory Support ◽  
Assist Device ◽  
Ventricular Assist ◽  
Left Ventricular Assist

Dilated cardiomyopathy is the most common type of the heart failure which can be characterized by impaired ventricular contractility. Mechanical circulatory support devices were introduced into practice for the heart failure patients to bridge the time between the decision to transplant and the actual transplantation which is not sufficient due to the state of donor organ supply. In this study, the hemodynamic response of a cardiovascular system that includes a dilated cardiomyopathic heart under support of a newly developed continuous flow left ventricular assist device—Heart Turcica Axial—was evaluated employing computer simulations. For the evaluation, a numerical model which describes the pressure-flow rate relations of Heart Turcica Axial, a cardiovascular system model describing the healthy and pathological hemodynamics, and a baroreflex model regulating the heart rate were used. Heart Turcica Axial was operated between 8000 rpm and 11000 rpm speeds with 1000 rpm increments for assessing the pump performance and response of the cardiovascular system. The results also give an insight about the range of the possible operating speeds of Heart Turcica Axial in a clinical application. Based on the findings, operating speed of Heart Turcica Axial should be between 10000 rpm and 11000 rpm.

scholarly journals A Novel Patient-Specific Human Cardiovascular System Phantom (HCSP) for Reconstructions of Pulsatile Blood Hemodynamic Inside Abdominal Aortic Aneurysm

IEEE Access ◽  
2018 ◽  
Vol 6 ◽  
pp. 61896-61903 ◽  
Author(s):  
Andrzej Polanczyk ◽  
Michal Podgorski ◽  
Maciej Polanczyk ◽  
Aleksandra Piechota-Polanczyk ◽  
Christoph Neumayer ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Cardiovascular System ◽  
Patient Specific ◽  
Abdominal Aortic ◽  
Human Cardiovascular System

scholarly journals Digital subtraction angiography of the human cardiovascular system

1980 ◽  
Vol 135 (6) ◽  
pp. 1153-1160 ◽  
Author(s):  
TF Meaney ◽  
MA Weinstein ◽  
E Buonocore ◽  
W Pavlicek ◽  
GP Borkowski ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Digital Subtraction Angiography ◽  
Digital Subtraction ◽  
Human Cardiovascular System

scholarly journals Exploring the complex interplay in the regulation of cardiac pathophysiological functions by protein kinases and phosphatases

2021 ◽  
Vol 6 (4) ◽  
pp. 165-170
Author(s):  
Dr Chrysanthus Chukwuma Sr
Keyword(s):  
Heart Failure ◽  
Cardiovascular System ◽  
Protein Kinases ◽  
Body Burden ◽  
The Body ◽  
Complex Interplay ◽  
Physiological Processes ◽  
Progressive Heart Failure ◽  
Drug Lead ◽  
Cardiac Excitation

Cardiovascular disease manifests as an intricately complex entity presenting as a derangement of the cardiovascular system. Cardiac or heart failure connotes the pathophysiological state in which deficient cardiac output compromises the body burden and requirements. Protein kinases regulate several pathophysiological processes and are emerging targets for drug lead or discovery. The protein kinases are family members of the serine/threonine phosphatases. Protein kinases and phosphatases are pivotal in the regulatory mechanisms in the reversible phosphorylation of diverse effectors whereby discrete signaling molecules regulate cardiac excitation and contraction. Protein phosphorylation is critical for the sustenance of cardiac functionalities. The two major contributory ingredients to progressive myocardium derangement are dysregulation of Ca2+processes and contemporaneous elevated concentrations of reactive oxygen species, ROS. Certain cardiac abnormalities include cardiac myopathy or hypertrophy due to response in untoward haemodynamic demand with concomitant progressive heart failure. The homeostasis or equilibrium between protein kinases and phosphatases influence cardiac morphology and excitability during pathological and physiological processes of the cardiovascular system.

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