Laboratory diagnosis of bacterial meningitis by direct detection, serotyping and Next Generation Sequencing: How 10 years of testing in New York State has evolved to improve laboratory diagnosis and public health

2021 ◽  
pp. 101786
Author(s):  
James R. Long ◽  
Kara Mitchell ◽  
Justine Edwards ◽  
Danielle Wroblewski ◽  
Elizabeth Luke ◽  
...  
2021 ◽  
Vol 7 (4) ◽  
pp. 73
Author(s):  
Robert J. Sicko ◽  
Colleen F. Stevens ◽  
Erin E. Hughes ◽  
Melissa Leisner ◽  
Helen Ling ◽  
...  

Newborn screening (NBS) for Cystic Fibrosis (CF) is associated with improved outcomes. All US states screen for CF; however, CF NBS algorithms have high false positive (FP) rates. In New York State (NYS), the positive predictive value of CF NBS improved from 3.7% to 25.2% following the implementation of a three-tier IRT-DNA-SEQ approach using commercially available tests. Here we describe a modification of the NYS CF NBS algorithm via transition to a new custom next-generation sequencing (NGS) platform for more comprehensive cystic fibrosis transmembrane conductance regulator (CFTR) gene analysis. After full gene sequencing, a tiered strategy is used to first analyze only a specific panel of 338 clinically relevant CFTR variants (second-tier), followed by unblinding of all sequence variants and bioinformatic assessment of deletions/duplications in a subset of samples requiring third-tier analysis. We demonstrate the analytical and clinical validity of the assay and the feasibility of use in the NBS setting. The custom assay has streamlined our molecular workflow, increased throughput, and allows for bioinformatic customization of second-tier variant panel content. NBS aims to identify those infants with the highest disease risk. Technological molecular improvements can be applied to NBS algorithms to reduce the burden of FP referrals without loss of sensitivity.


1971 ◽  
Vol 1 (1) ◽  
pp. 9-14 ◽  
Author(s):  
John S. Sinacore

Recognizing that problems arising from human ecology do not represent medical failure so much as educational failure, and that prevention is cheaper in the long run than rehabilitation, the New York State Education Department is implementing a course of study in the Health Sciences incorporating knowledge from the disciplines of medical science and public health, aimed at prevention through education. Curriculum materials for 4th grade through high school, developed by the State Education Department, deal initially with the nature and proper use of drugs as a basis for understanding drug abuse. Drug education, to be effective as a drug abuse deterrent, should be taught by a well prepared health education teacher within the context of health education which touches on areas of mental health, physical health, consumer health, public health, safety and pharmacology. Intensive teacher training programs are underway in six institutions of higher education in New York State to prepare teachers licensed in other educational areas to fulfill state certification requirements in health education. Additional teachers are being trained to teach inservice courses in their own districts; their $600 salary per 30 hour course taught is paid by the State Education Department. The goal is to reach 7500 teachers during this school year. The program participants are brought into contact with consultants from many related fields. A learn-by-doing method is utilized involving group processes and activities designed to encourage individuals to become responsible for their own learning and the learning of others.


2021 ◽  
Vol 111 (10) ◽  
pp. 1780-1783
Author(s):  
Thomas E. Smith ◽  
Ian T. Rodgers ◽  
Daniel J. Silverman ◽  
Sally R. Dreslin ◽  
Mark Olfson ◽  
...  

Individuals with serious mental illness are particularly vulnerable to COVID-19. The New York State (NYS) Office of Mental Health implemented patient and staff rapid testing, quarantining, and vaccination to limit COVID-19 spread in 23 state-operated psychiatric hospitals between November 2020 and February 2021. COVID-19 infection rates in inpatients and staff decreased by 96% and 71%, respectively, and the NYS population case rate decreased by 6%. Repeated COVID-19 testing and vaccination should be priority interventions for state-operated psychiatric hospitals. (Am J Public Health. 2021;111(10):1780–1783. https://doi.org/10.2105/AJPH.2021.306444 )


PEDIATRICS ◽  
1974 ◽  
Vol 53 (1) ◽  
pp. 124-124
Author(s):  
Selig H. Katz

In a letter published in the August 1973 issue, Dr. Hania W. Ris suggests routine screening of women for gonorrhea. A recently enacted amendment to the Public Health Law of New York State requires all physicians, clinics or facilities providing gynecological, obstetrical, contraceptive, sterilization or termination-of-pregnancy services or treatment to offer to administer to every New York State resident coming for such services or treatment, appropriate tests for the detection of syphilis and gonorrhea.


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