Current status of iron metabolism: Clinical and therapeutic implications

2017 ◽  
Vol 148 (5) ◽  
pp. 218-224 ◽  
Author(s):  
Susana Conde Diez ◽  
Ricardo de las Cuevas Allende ◽  
Eulogio Conde García
Keyword(s):  
Iron Metabolism ◽  
Current Status ◽  
Therapeutic Implications

scholarly journals Psychomotor Retardation in Depression: A Systematic Review of Diagnostic, Pathophysiologic, and Therapeutic Implications

2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Djamila Bennabi ◽  
Pierre Vandel ◽  
Charalambos Papaxanthis ◽  
Thierry Pozzo ◽  
Emmanuel Haffen
Keyword(s):  
Mood Disorders ◽  
Bipolar Depression ◽  
Psychomotor Retardation ◽  
Current Status ◽  
Central Feature ◽  
Therapeutic Implications ◽  
Functional Deficits ◽  
Diagnostic Management ◽  
Depressive Subtypes ◽  
The Individual

Psychomotor retardation is a central feature of depression which includes motor and cognitive impairments. Effective management may be useful to improve the classification of depressive subtypes and treatment selection, as well as prediction of outcome in patients with depression. The aim of this paper was to review the current status of knowledge regarding psychomotor retardation in depression, in order to clarify its role in the diagnostic management of mood disorders. Retardation modifies all the actions of the individual, including motility, mental activity, and speech. Objective assessments can highlight the diagnostic importance of psychomotor retardation, especially in melancholic and bipolar depression. Psychomotor retardation is also related to depression severity and therapeutic change and could be considered a good criterion for the prediction of therapeutic effect. The neurobiological process underlying the inhibition of activity includes functional deficits in the prefrontal cortex and abnormalities in dopamine neurotransmission. Future investigations of psychomotor retardation should help improve the understanding of the pathophysiological mechanisms underlying mood disorders and contribute to improving their therapeutic management.

scholarly journals Stem Cells: Current Status and Therapeutic Implications

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1372
Author(s):  
Kaladhar B. Reddy
Keyword(s):  
Stem Cells ◽  
Tumor Recurrence ◽  
Tumor Heterogeneity ◽  
Therapeutic Strategies ◽  
Current Status ◽  
Therapeutic Resistance ◽  
Major Difficulty ◽  
Biological Mechanisms ◽  
Pluripotent Cells ◽  
Therapeutic Implications

Cancer stem cells (CSCs) are a class of pluripotent cells that have been observed in most types of cancers. Evolving evidence suggests that CSCs, has the ability to self-renew and initiate tumors, may be responsible for promoting therapeutic resistance, tumor recurrence and metastasis. Tumor heterogeneity is originating from CSCs and its progenitors are recognized as major difficulty in efficaciously treating cancer patients. Therefore, understanding the biological mechanisms by which CSCs survive chemo- and-radiation therapy has the potential to identify new therapeutic strategies in the future. In this review, we summarized recent advances in CSC biology and their environment, and discuss about the potential therapies to prevent therapeutic resistance.

scholarly journals DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications

2018 ◽  
Vol 12 (1) ◽  
pp. 37-49 ◽  
Author(s):  
Antonio Miranda-Duarte
Keyword(s):  
Dna Methylation ◽  
Genetic Factors ◽  
Methylation Status ◽  
Gene Repression ◽  
Current Status ◽  
Multifactorial Disease ◽  
Review Of The Literature ◽  
Therapeutic Implications ◽  
Genome Wide

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA. Objective: This review is focused on the current status of DNA methylation studies related to OA pathogenesis. Method: A review of the literature was conducted on searching in PUBMED for original papers on DNA methylation in OA. Conclusion: The DNA methylation research of loci related to OA pathogenesis has shown a correlation between methylation and gene repression; however, there are some exceptions to this rule. Recently, the development of genome-wide methylation and genome-wide hydroxymethylation profiles has demonstrated that several genes previously associated with OA can have changes in their methylation status, favoring the development of the disease, and these have even shown the role of other epigenetic markers.

Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

2020 ◽  
Vol 41 (1) ◽  
pp. 275-313 ◽  
Author(s):  
Antonis S. Manolis ◽  
Antonis A. Manolis ◽  
Theodora A. Manolis ◽  
Naomi E. Apostolaki ◽  
Evdoxia J. Apostolopoulos ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Mitochondrial Dysfunction ◽  
Translational Research ◽  
Current Status ◽  
Therapeutic Implications

scholarly journals Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications

2022 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Doris Ogresta ◽  
Anna Mrzljak ◽  
Maja Cigrovski Berkovic ◽  
Ines Bilic-Curcic ◽  
Sanja Stojsavljevic-Shapeski ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Current Status ◽  
Therapeutic Implications

Cancer Stem Cells: Current Status and Therapeutic Implications in Cancer Therapy- a New Paradigm

2021 ◽  
Vol 16 ◽  
Author(s):  
Suman Kumar Ray ◽  
Sukhes Mukherjee
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapy Resistance ◽  
Current Status ◽  
Environmental Niche ◽  
Malignant Growth ◽  
New Paradigm ◽  
Promising Technique ◽  
Therapeutic Implications ◽  
Traditional Therapies

Recent evidence confirms that not each tumor cell is proficient in instigating a tumor. Merely a small part of the cancer cells, so-called cancer stem cells (CSCs), can produce cancer indistinguishable from the first one. CSC model has been recognized as a cellular component that adds to phenotypic and functional heterogeneity in different cancers. Latest explanations have featured numerous complexities and difficulties like CSC phenotype that can differ extensively between patients. Tumors may harbor various phenotypically or genetically specific CSCs, and consequently, metastatic CSCs can develop from vital CSCs and tumor cells. Scientists have discovered a few markers for CSCs. The recent finding reveals that CSCs are resistant to radiotherapy and chemotherapy and may clarify the disease's reappearance. Minimal amounts of CSCs can repopulate a tumor. Subsequently, it is essential to understand the attributes and mechanisms by which CSCs show their resistance to therapeutic agents. These aptitudes contribute to new bits of knowledge that gives better therapeutic motivations to discover novel anticancer therapeutics. Accordingly, remedial procedures that emphasize focusing on CSCs and their micro environmental niche are insufficient for conventional malignant growth treatments to eradicate the CSCs that, in any case, bring about therapy resistance. Mutual utilization of traditional therapies with CSC- specific agents may offer a promising technique for enduring cancer treatment as well as remedy.

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