Methicillin-resistant Staphylococcus aureus among a network of French private-sector community-based-medical laboratories

A prevalence survey of nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage was undertaken on a random sample of adults (aged over 16) resident in the community in Birmingham, UK during 1998. Microbiological samples were taken from the anterior nares at the subjects' general practice or in their home. Information about risk factors for the acquisition of MRSA was obtained via a self-completed questionnaire. A 58% response rate (280/483) was achieved. The prevalence of nasal MRSA colonization was 1.5% [4/274, 95% confidence interval (CI) 0.03–2.9%]. Twenty-three per cent (63/274) of subjects were nasal carriers of S. aureus. Six per cent (4/63) of S. aureus isolates were MRSA and 2 of the 4 MRSA carriers reported previous contact with health facilities. The prevalence of MRSA colonization in the general adult population in Birmingham appears to be low.

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Progressive increase in community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations in northern Australia from 1993 to 2012

Epidemiology and Infection ◽

10.1017/s0950268814002611 ◽

2014 ◽

Vol 143 (7) ◽

pp. 1519-1523 ◽

Cited By ~ 28

Author(s):

S. Y. C. TONG ◽

L. VARRONE ◽

M. D. CHATFIELD ◽

M. BEAMAN ◽

P. M. GIFFARD

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Methicillin Resistance ◽

Indigenous Communities ◽

Progressive Increase ◽

Northern Territory ◽

Indigenous Populations ◽

Northern Australia ◽

Community Based ◽

Methicillin Resistant

SUMMARYHospital-based studies have determined high rates of community-associated methicillin-resistant Staphylococcus aureus (MRSA) in Indigenous populations. However, there is a paucity of community-based data. We obtained 20 years (1993–2012) of data on S. aureus isolates (N = 20 210) collected from community clinics that provide services for Indigenous communities in the Northern Territory, Australia. Methicillin resistance increased from 7% to 24%, resistance to macrolides remained stable at ~25%, and there was a slight increase in resistance to trimethoprim-sulfamethoxazole. The increase in methicillin resistance is concerning for the Indigenous communities represented by this data, but it is also of significance if virulent MRSA clones emerge and spread more widely from such settings.

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Trends in Methicillin resistant staphylococcus aureus (MRSA) minimal inhibitory concentration (MIC) to Vancomycin over a 2 year period in a community based hospital

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2010.02.395 ◽

2010 ◽

Vol 14 ◽

pp. e348-e349

Author(s):

J. Murillo ◽

C. Garcia ◽

F. Ordieres

Keyword(s):

Staphylococcus Aureus ◽

Minimal Inhibitory Concentration ◽

Methicillin Resistant Staphylococcus Aureus ◽

Inhibitory Concentration ◽

Community Based ◽

Methicillin Resistant

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Community-associated methicillin-resistant Staphylococcus aureus is prevalent in wounds of community-based injection drug users

Epidemiology and Infection ◽

10.1017/s0950268810000464 ◽

2010 ◽

Vol 138 (5) ◽

pp. 713-720 ◽

Cited By ~ 23

Author(s):

E. LLOYD-SMITH ◽

M. W. HULL ◽

M. W. TYNDALL ◽

R. ZHANG ◽

E. WOOD ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Injection Drug Users ◽

Drug Users ◽

Methicillin Resistant Staphylococcus Aureus ◽

Injection Drug ◽

Community Based ◽

Methicillin Resistant ◽

Genes Encoding ◽

Susceptibility Profiles ◽

Culture Positive

SUMMARYInjection drug users (IDUs) have an elevated risk for carriage of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA). Cutaneous injection-related infections are common in IDUs but detailed studies are few. Based on a subsample of 218 individuals from a community-recruited cohort of IDUs at a supervised injection facility, we investigated the microbiology and related antibiotic susceptibility profiles of isolates from 59 wounds. Twenty-seven percent of subjects had at least one wound and 25 (43%) were culture positive for S. aureus alone [14 MRSA and 11 (19%) methicillin-susceptible (MSSA) isolates]. Sixteen of 18 MRSA isolates were classified as community associated (CA) by the presence of genes encoding for PVL. MRSA and MSSA occurred in mixed infection with other organisms on three and six occasions, respectively. All CA-MRSA isolates were susceptible to tetracycline, vancomycin and linezolid but only 13% were susceptible to clindamycin compared to 63% of MSSA isolates. The frequency of CA-MRSA is a cause for concern in wound infection in the IDU setting.

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Prevalence, risk factors, phenotypic and molecular characteristics for methicillin-resistant Staphylococcus aureus carriage in community-based drug users in Guangzhou, China

10.21203/rs.2.17914/v1 ◽

2019 ◽

Author(s):

Yingying Wang ◽

Jialing Lin ◽

Junli Zhou ◽

Zhigang Han ◽

Zhenjiang Yao

Keyword(s):

Risk Factors ◽

Staphylococcus Aureus ◽

Drug Users ◽

Methicillin Resistant Staphylococcus Aureus ◽

Nasal Carriage ◽

Molecular Characteristics ◽

Community Based ◽

Cross Sectional ◽

Methicillin Resistant ◽

The Cross

Abstract Background: Staphylococcus aureus ( S. aureus ) and methicillin-resistant Staphylococcus aureus (MRSA) remained the predominant cause of infections in drug users. The cross-sectional study aimed to elucidate the prevalence, risk factors, phenotypic and molecular characteristics of S. aureus and MRSA carriage among community-based drug users. Methods: Eligible drug users were asked to complete questionnaires and collect nasal swabs during May and December 2017 in Guangzhou, China. Swabs were processed for identification of S. aureus and MRSA. Antimicrobial susceptibility test and polymerase chain reaction assays were used to detect phenotypic and molecular characteristics for identified isolates. Univariate and multivariate logistic regression analyses were used to assess risk factors for S. aureus and MRSA carriage. Results: Overall, the prevalence of S. aureus and MRSA carriage in 353 drug users were 15.01% and 6.79%, respectively. Cohabitation was a risk factor for S. aureus (adjusted OR=8.80, 95% CI: 1.89-40.99) and MRSA (adjusted OR=14.30, 95% CI: 2.67-76.46) carriage. The proportions of multidrug resistance were respectively 72.41% and 89.47% for S. aureus and MRSA isolates and were simultaneously resistant to penicillin, erythromycin and clindamycin. The results of clonal complexes and sequence types for S. aureus and MRSA isolates were diverse. The proportions of virulence genes were high for MRSA isolates. Conclusion: The prevalence of S. aureus nasal carriage was lower while the prevalence of MRSA nasal carriage was moderate. Phenotypic and molecular characteristics of MRSA isolates revealed serious antibiotic resistance, indicating the cross-circulation of MRSA isolates, and imply high opportunity of virulence-related diseases. Decolonization might be considered for drug users with MRSA carriage, especially for those with risk factors.

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STAPHYLOCOCCUS AUREUS RESISTANCE AGAINST CEPHALOSPORIN ANTIBIOTIC IN ADEN-YEMEN

Electronic Journal of University of Aden for Basic and Applied Sciences ◽

10.47372/ejua-ba.2021.3.108 ◽

2021 ◽

Vol 2 (3) ◽

pp. 139-144

Author(s):

Eman Abdo Ali ◽

Omniat N. M. Alshuaibi ◽

Khaled S. A. Alsweedi

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Resistance Ratio ◽

Clinical Samples ◽

Antibacterial Resistance ◽

Methicillin Resistant ◽

Medical Laboratories ◽

Cephalosporin Antibiotic

The study was carried out to determine antibacterial resistance profiles of methicillin-resistant Staphylococcus aureus (MRSA), isolated from clinical samples (n: 352) of patients during the period, from January 2019 to July 2020 in five governmental and private medical laboratories of Aden governorate, Yemen. The results showed the percentage for resistance ratio is differentiated between samples and the category of cephalosporin antibiotic groups. The highest percentage of resistance was in the wound sample for Cefadroxil, Cefuroxime, and Ceftriaxone at (100%), in addition to 100% in the pus, CSF, and sputum samples for Ceftriaxone antibiotic. Moreover, Cefadroxil has 100 % of resistance in semen, ear, and sputum samples. However, the Staphylococcus aureus isolated from the pharyngeal sample not showed any resistance to all cephalosporin antibiotic groups.

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