Increased resistin may suppress reactive oxygen species production and inflammasome activation in type 2 diabetic patients with pulmonary tuberculosis infection

2015 ◽  
Vol 17 (3) ◽  
pp. 195-204 ◽  
Author(s):  
Wen-Cheng Chao ◽  
Chia-Liang Yen ◽  
Ying-Hsun Wu ◽  
Shin-Yi Chen ◽  
Cheng-Yuan Hsieh ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Pulmonary Tuberculosis ◽  
Reactive Oxygen Species Production ◽  
Diabetic Patients ◽  
Inflammasome Activation ◽  
Oxygen Species ◽  
Type 2 Diabetic Patients ◽  
Species Production ◽  
Type 2 Diabetic

Markers of Oxidative Stress in the Saliva of Type 2 Diabetic Patients (Preprint)

2020 ◽  
Author(s):  
Olatunde Olayanju ◽  
Chika Juiet Okwor ◽  
Gabriel Nku Odok Jr ◽  
Gabriel Nku Odok Jr ◽  
Nnaemeka Elvis Awah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Reactive Oxygen Species ◽  
Diabetic Patients ◽  
Oxygen Species ◽  
Oral Diseases ◽  
Type 2 Diabetic Patients ◽  
Markers Of Oxidative Stress ◽  
Type 2 Diabetic

BACKGROUND Diabetes mellitus is associated with increased prevalence of oral diseases. Reactive oxygen species have been implicated in the development of these diseases. The saliva contains a balanced proportion of protective antioxidants and reactive oxygen species, disrupting this balance favours disease development. However, level of salivary markers of oxidative stress has not been sufficiently studied in the diabetics. OBJECTIVE Thus, this study aimed to measure salivary H2O2, NO and MDA in diabetic patients in comparison to non-diabetic controls. METHODS A total of 166 adults comprising of 95 Type 2 diabetic patients and 71 healthy non-diabetic controls were recruited for this study. About 3 ml of unstimulated saliva samples were collected from participants after rinsing their mouth with clean water. Levels of H2O2, NO and MDA were measured in all saliva samples using spectrophotometry. Data was analysed using t-test, logistic regression and receiver operating characteristics (ROC) with statistical significance set at p<0.05. RESULTS Salivary H2O2 (p=0.024) and NO (p=0.002) were significantly higher in the diabetic patients when compared to the healthy non-diabetic control group. Binary logistic regression showed that patients with Type 2 diabetic mellitus are more likely to have elevated salivary H2O2 (OR= 1.013; p=0.025) and NO (OR=1.016; p=0.003) levels. ROC analysis showed statistically significant performance of salivary NO levels in distinguishing between T2DM patients and healthy controls. CONCLUSIONS Higher levels of salivary H2O2 and NO could be a pointer to the high prevalence of oral diseases in diabetes mellitus. This calls for increased attention to oral health in diabetes management.

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

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