Evaluation of the β-barrel outer membrane protein VP1243 as a candidate antigen for a cross-protective vaccine against Vibrio infections

2020 ◽  
Vol 147 ◽  
pp. 104419 ◽  
Author(s):  
Zhichao Gao ◽  
Chen Ye ◽  
Lantian Zhou ◽  
Yue Zhang ◽  
Yongze Ge ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Candidate Antigen

scholarly journals Identification of Protective Epitopes by Sequencing of the Major Outer Membrane Protein Gene of a Variant Strain ofChlamydia psittaci Serotype 1 (Chlamydophila abortus)

2001 ◽  
Vol 69 (1) ◽  
pp. 607-612 ◽  
Author(s):  
Evangelia Vretou ◽  
Evgenia Psarrou ◽  
Maria Kaisar ◽  
Isabella Vlisidou ◽  
Viviane Salti-Montesanto ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Major Outer Membrane Protein ◽  
Variant Strain ◽  
The Family ◽  
Serotype 1 ◽  
Vaccine Candidate Antigen ◽  
Membrane Protein Gene ◽  
Candidate Antigen

ABSTRACT Protective monoclonal antibodies (MAbs) to the major outer membrane protein (MOMP) of species of the family Chlamydiaceae, which is the primary vaccine candidate antigen, recognize nonlinear epitopes conferred by the oligomeric conformation of the molecule. Protective MAbs failed to recognize oligomeric MOMP of the variant strain LLG, which bears amino acid substitutions in variable segments (VSs) 1, 2, and 4, and competed with monomer-specific MAbs mapping to these VSs in reference strain 577. The results suggest that multiple sites located in the three VSs contribute to the epitope of protective MAbs.

Overexpression of Outer Membrane Protein A Is a Risk Factor for Mortality in Escherichia coli Bloodstream Infections

2019 ◽  
Author(s):  
Ángel Rodríguez-Villodres ◽  
Rocío Álvarez-Marín ◽  
María Antonia Pérez-Moreno ◽  
Andrea Miró-Canturri ◽  
Marco Durán Lobato ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Risk Factor ◽  
Membrane Protein ◽  
Outer Membrane ◽  
Outer Membrane Protein ◽  
Protein A ◽  
Bloodstream Infections ◽  
Outer Membrane Protein A
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