Evaluation of colloidal properties of amino-functionalized mesoporous silica nanoparticles conjugated with the plasmid vector pEGFP-N3 and its influence on the pDNA delivery to HeLa cells

2021 ◽  
pp. 111562
Author(s):  
Laura C. Crapina ◽  
Sang W. Han ◽  
Marcos A. Bizeto
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Hela Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Plasmid Vector ◽  
Functionalized Mesoporous Silica ◽  
Colloidal Properties

Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects

Langmuir ◽  
2016 ◽  
Vol 32 (50) ◽  
pp. 13394-13402 ◽  
Author(s):  
Nayere Taebnia ◽  
Dina Morshedi ◽  
Soheila Yaghmaei ◽  
Farhang Aliakbari ◽  
Fatemeh Rahimi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

scholarly journals Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1196
Author(s):  
Carla Vidaurre-Agut ◽  
Eva María Rivero-Buceta ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Incubation Temperature ◽  
Mesoporous Silica Nanoparticles ◽  
Nanoparticle Concentration ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized ◽  
Commercial Kit ◽  
Higher Sensitivity

To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed. Process parameters including miRNA type, nanoparticle concentration, incubation temperature and incubation time were investigated, as well as the potential competition for adsorption between different miRNA molecules. The influence of proteins and particle PEGylation on miRNA adsorption were also explored. We found that low particle concentrations and physiological temperature both led to increased miRNA adsorption. Adsorption of miRNA was also higher when proteins were present in the same solution; reducing or preventing protein adsorption by PEGylating the MSNs hindered adsorption. Finally, the amount of miRNA adsorbed from human serum by MSN-NH2 was compared to a commercial miRNA purification kit (TaqMan®, Life Technologies, Carlsbad, CA, USA). MSN-NH2 adsorbed six times as much miRNA as the commercial kit, demonstrating higher sensitivity to subtle up- and downregulation of circulating miRNA in the blood of patients.

Tobacco Mosaic Virus-Functionalized Mesoporous Silica Nanoparticles, a Wool-Ball-like Nanostructure for Drug Delivery

Langmuir ◽  
2018 ◽  
Vol 35 (1) ◽  
pp. 203-211 ◽  
Author(s):  
Laura Marín-Caba ◽  
Paul L. Chariou ◽  
Carmen Pesquera ◽  
Miguel A. Correa-Duarte ◽  
Nicole F. Steinmetz
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Tobacco Mosaic Virus ◽  
Silica Nanoparticles ◽  
Mosaic Virus ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica

scholarly journals Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Daniel Pedraza ◽  
Jaime Díez ◽  
Isabel Izquierdo-Barba ◽  
Montserrat Colilla ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Chemical Properties ◽  
Bone Infection ◽  
Bacterial Biofilm ◽  
Functionalized Mesoporous Silica ◽  
Transmission Electron ◽  
Infection Treatment ◽  
Physical And Chemical

AbstractThis manuscript reports an effective new alternative for the management of bone infection by the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also denoted as “nanoantibiotic”, consists in mesoporous silica nanoparticles (MSNs) loaded with an antimicrobial agent (levofloxacin, LEVO) and externally functionalized with N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (DAMO) as targeting agent. This amine functionalization provides MSNs of positive charges, which improves the affinity towards the negatively charged bacteria wall and biofilm. Physical and chemical properties of the nanoantibiotic were studied using different characterization techniques, including Xray diffraction (XRD), transmission electron microscopy (TEM), N

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