Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

Abstract This manuscript reports an effective new alternative for the management of bone infection by the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also denoted as “nanoantibiotic”, consists in mesoporous silica nanoparticles (MSNs) loaded with an antimicrobial agent (levofloxacin, LEVO) and externally functionalized with N-(2-aminoethyl)-3- aminopropyltrimethoxysilane (DAMO) as targeting agent. This amine functionalization provides MSNs of positive charges, which improves the affinity towards the negatively charged bacteria wall and biofilm. Physical and chemical properties of the nanoantibiotic were studied using different characterization techniques, including Xray diffraction (XRD), transmission electron microscopy (TEM), N2 adsorption porosimetry, elemental chemical analysis, dynamic light scattering (DLS), zeta (ζ)-potential and solid-state nuclear magnetic resonance (NMR). “In vial” LEVO release profiles and the in vitro antimicrobial effectiveness of the different released doses were investigated. The efficacy of the nanoantibiotic against a S. aureus biofilm was also determined, showing the practically total destruction of the biofilm due to the high penetration ability of the developed nanosystem. These findings open up promising expectations in the field of bone infection treatment.

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Synthesis and Characterization of Thiol- and Carboxyl-Functionalized Mesoporous Silica Nanoparticles

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1142.220 ◽

2017 ◽

Vol 1142 ◽

pp. 220-224 ◽

Cited By ~ 1

Author(s):

Wan Xia Wang ◽

Yu Wang ◽

Hua Meng Gong ◽

Hong Hao Sun ◽

Ming Xing Liu

Keyword(s):

Electron Microscopy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Spherical Shape ◽

Synthesis And Characterization ◽

Functionalized Mesoporous Silica ◽

Transmission Electron ◽

Ft Ir

The purpose of this article is to synthesize the thiol-and carboxyl-bifunctionalized mesoporous silica nanoparticles (CMS-SH-COOH). CMS-SH-COOH was successfully synthesized by co-condensation and post-grafting methods. Moreover, the particle size and structural properties of CMS-SH-COOH were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR). The obtained results indicated that the CMS-SH-COOH presented a uniform spherical shape with a wormhole arrangement of the mesopores and a relatively narrow paticle distribition. Therefore, the CMS-SH-COOH might be a great potential carrier for the drug delivery system in the future.

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Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment

Pharmaceutics ◽

10.3390/pharmaceutics13122033 ◽

2021 ◽

Vol 13 (12) ◽

pp. 2033

Author(s):

Elena Álvarez ◽

Blanca González ◽

Daniel Lozano ◽

Antonio L. Doadrio ◽

Montserrat Colilla ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Materials ◽

Mesoporous Silica Nanoparticles ◽

Chemical Properties ◽

Future Application ◽

General Context ◽

Stimuli Responsive ◽

Infection Treatment

This review focuses on the design of mesoporous silica nanoparticles for infection treatment. Written within a general context of contributions in the field, this manuscript highlights the major scientific achievements accomplished by professor Vallet-Regí’s research group in the field of silica-based mesoporous materials for drug delivery. The aim is to bring out her pivotal role on the envisage of a new era of nanoantibiotics by using a deep knowledge on mesoporous materials as drug delivery systems and by applying cutting-edge technologies to design and engineer advanced nanoweapons to fight infection. This review has been divided in two main sections: the first part overviews the influence of the textural and chemical properties of silica-based mesoporous materials on the loading and release of antibiotic molecules, depending on the host–guest interactions. Furthermore, this section also remarks on the potential of molecular modelling in the design and comprehension of the performance of these release systems. The second part describes the more recent advances in the use of mesoporous silica nanoparticles as versatile nanoplatforms for the development of novel targeted and stimuli-responsive antimicrobial nanoformulations for future application in personalized infection therapies.

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Synthesis and Testing of Functional Mesoporous Silica Nanoparticles for Removal of Cr(VI) Ions From Water

Biointerface Research in Applied Chemistry ◽

10.33263/briac112.85998607 ◽

2020 ◽

Vol 11 (2) ◽

pp. 8599-8607

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Porous Silica ◽

Nitrogen Adsorption ◽

Attenuated Total Reflection ◽

Functionalized Mesoporous Silica ◽

Adsorption Removal ◽

Transmission Electron ◽

Adsorption Desorption

This work reports a reliable and reproducible synthesis and in situ functionalization protocol for the synthesis of amino-functionalized mesoporous silica nanoparticles (MSNs). The porous amino-functional (pSiO2-NH2) nanoparticles were fully characterized by high-resolution transmission electron microscopy (TEM), X-ray diffraction (XRD), Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and nitrogen adsorption-desorption (BET) analyses. The size of the particles was in the range of 80-200 nm with a specific surface area (SSA) of 721 m2 g-1, and the pore diameter was 31Å. The pSiO2-NH2 nanoparticles were tested for their efficiency in removing Cr(VI) ions from water. Almost quantitative removal of the ions was achieved by using the particles just within two hours. The adsorption efficiency of the particles was about 50 mg g-1. The synthesized porous silica particles can be repeatedly used as nano adsorbent for the adsorption removal of Cr(VI) ions from water. The nanoparticles can be potentially used for the selective capture, removal, and recovery of various other metal ions that can be complexed by amino groups.

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Cover Picture: Differential Effects of Polymer-Surface Decoration on Drug Delivery, Cellular Retention, and Action Mechanisms of Functionalized Mesoporous Silica Nanoparticles (Chem. Asian J. 12/2015)

Chemistry - An Asian Journal ◽

10.1002/asia.201501121 ◽

2015 ◽

Vol 10 (12) ◽

pp. 2541-2541 ◽

Cited By ~ 1

Author(s):

Yuanyuan You ◽

Hao Hu ◽

Lizhen He ◽

Tianfeng Chen

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Polymer Surface ◽

Differential Effects ◽

Functionalized Mesoporous Silica ◽

Action Mechanisms ◽

Surface Decoration

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Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

International Journal of Molecular Sciences ◽

10.3390/ijms21249696 ◽

2020 ◽

Vol 21 (24) ◽

pp. 9696

Author(s):

Miguel Gisbert-Garzarán ◽

Daniel Lozano ◽

María Vallet-Regí

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

State Of The Art ◽

Mesoporous Silica Nanoparticles ◽

Drug Distribution ◽

Chemical Properties ◽

Drug Carriers ◽

Subcellular Organelles ◽

Physico Chemical ◽

Tumoral Cells

Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus.

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