Real-time scan speed control of the atomic force microscopy for reducing imaging time based on sample topography

Micron ◽  
2018 ◽  
Vol 106 ◽  
pp. 1-6 ◽  
Author(s):  
Yingxu Zhang ◽  
Yingzi Li ◽  
Guanqiao Shan ◽  
Yifu Chen ◽  
Zhenyu Wang ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Real Time ◽  
Speed Control ◽  
Force Microscopy ◽  
Atomic Force ◽  
Imaging Time ◽  
Scan Speed ◽  
Time Scan

scholarly journals Atomic force microscopy reveals the role of vascular smooth muscle cell elasticity in hypertension

2020 ◽  
Author(s):  
Yi Zhu
Keyword(s):  
Atomic Force Microscopy ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Real Time ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Research Subjects ◽  
Force Microscopy ◽  
Atomic Force

AbstractThe vascular smooth muscle cell (VSMC) mechanical properties not only provide intrinsic cellular functions, but also influence many vascular and circulation functions in physiology. In this report, the VSMCs of thoracic aorta from 16 week age Wistar-Kyoto normotensive rats (WKY) and spontaneously hypertensive rats (SHR) were used as research subjects to reveal hypertension mechanism at a single cell level using atomic force microscopy (AFM). The apparent elastic modulus was significantly increased in VSMCs from SHRs compared to those from WKYs. Treatment with cytochalasin D (CD), ML7, Y27632 and lysophosphatidic acid (LPA) modulated VSMC stiffness of WKYs and SHRs. A spectral analysis approach was applied to further investigate the time-dependent change in VSMC elasticity of WKYs and SHRs. This report demonstrated the efficacy of real-time analysis of VSMC elasticity by AFM nano-indentation, and revealed real-time functional differences in biomechanical characteristics of VSMCs with drug treatments.

Sensor Referenced Real-Time Videolization of Atomic Force Microscopy for Nanomanipulations

2008 ◽  
Vol 13 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Lianqing Liu ◽  
Yilun Luo ◽  
Ning Xi ◽  
Yuechao Wang ◽  
Jiangbo Zhang ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Real Time ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Scanning speed phenomenon in contact-resonance atomic force microscopy

2018 ◽  
Vol 9 ◽  
pp. 945-952 ◽  
Author(s):  
Christopher C Glover ◽  
Jason P Killgore ◽  
Ryan C Tung
Keyword(s):  
Atomic Force Microscopy ◽  
Hydrodynamic Theory ◽  
Squeeze Film ◽  
Resonance Spectroscopy ◽  
Related Phenomenon ◽  
Contact Mode ◽  
Force Microscopy ◽  
Atomic Force ◽  
Scan Speed ◽  
Contact Resonance

This work presents data confirming the existence of a scan speed related phenomenon in contact-mode atomic force microscopy (AFM). Specifically, contact-resonance spectroscopy is used to interrogate this phenomenon. Above a critical scan speed, a monotonic decrease in the recorded contact-resonance frequency is observed with increasing scan speed. Proper characterization and understanding of this phenomenon is necessary to conduct accurate quantitative imaging using contact-resonance AFM, and other contact-mode AFM techniques, at higher scan speeds. A squeeze film hydrodynamic theory is proposed to explain this phenomenon, and model predictions are compared against the experimental data.

scholarly journals Real-Time Nanoparticle–Cell Interactions in Physiological Media by Atomic Force Microscopy

2014 ◽  
Vol 2 (7) ◽  
pp. 1681-1690 ◽  
Author(s):  
Georgios Pyrgiotakis ◽  
Christoph O. Blattmann ◽  
Philip Demokritou
Keyword(s):  
Atomic Force Microscopy ◽  
Real Time ◽  
Cell Interactions ◽  
Force Microscopy ◽  
Atomic Force
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