scholarly journals Real-Time Nanoparticle–Cell Interactions in Physiological Media by Atomic Force Microscopy

2014 ◽  
Vol 2 (7) ◽  
pp. 1681-1690 ◽  
Author(s):  
Georgios Pyrgiotakis ◽  
Christoph O. Blattmann ◽  
Philip Demokritou
2020 ◽  
Author(s):  
Yi Zhu

AbstractThe vascular smooth muscle cell (VSMC) mechanical properties not only provide intrinsic cellular functions, but also influence many vascular and circulation functions in physiology. In this report, the VSMCs of thoracic aorta from 16 week age Wistar-Kyoto normotensive rats (WKY) and spontaneously hypertensive rats (SHR) were used as research subjects to reveal hypertension mechanism at a single cell level using atomic force microscopy (AFM). The apparent elastic modulus was significantly increased in VSMCs from SHRs compared to those from WKYs. Treatment with cytochalasin D (CD), ML7, Y27632 and lysophosphatidic acid (LPA) modulated VSMC stiffness of WKYs and SHRs. A spectral analysis approach was applied to further investigate the time-dependent change in VSMC elasticity of WKYs and SHRs. This report demonstrated the efficacy of real-time analysis of VSMC elasticity by AFM nano-indentation, and revealed real-time functional differences in biomechanical characteristics of VSMCs with drug treatments.


2008 ◽  
Vol 13 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Lianqing Liu ◽  
Yilun Luo ◽  
Ning Xi ◽  
Yuechao Wang ◽  
Jiangbo Zhang ◽  
...  

2009 ◽  
Vol 80 (10) ◽  
pp. 103701 ◽  
Author(s):  
Pranav Agarwal ◽  
Tathagata De ◽  
Murti V. Salapaka

2017 ◽  
Vol 53 (98) ◽  
pp. 13172-13175 ◽  
Author(s):  
Keito Koizumi ◽  
Masaaki Akamatsu ◽  
Kenichi Sakai ◽  
Shinya Sasaki ◽  
Hideki Sakai

A solubilization-induced morphological change in surfactant surface aggregates was imaged in real-time, using high-speed atomic force microscopy.


2015 ◽  
Vol 108 (2) ◽  
pp. 633a
Author(s):  
Ronald Aucapina ◽  
Nadia Ouedraogo ◽  
Megan A. Ferguson

2014 ◽  
Vol 118 (11) ◽  
pp. 5789-5795 ◽  
Author(s):  
Nai-Ning Yin ◽  
Alexander Buyanin ◽  
Shawn L. Riechers ◽  
Olivia P. Lee ◽  
Jean M. J. Fréchet ◽  
...  

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