Geometrical structures, thermal properties and spectroscopic studies of Schiff base complexes: Correlation between ionic radius of metal complexes and DNA binding

A new series of Schiff base complexes of transition (Fe3+, Co2+, Ni2+, Cu2+ and Zn2+) metal were synthesized from 4-fluoroaniline and 2-thiophene carboxaldehyde and structurally characterized by spectroscopic techniques. The Schiff base is found to be a bidentate ligand and coordinates to the metal ion through azomethine nitrogen and sulphur atom of the thiophene ring. In fluorescence studies, an interaction of Ca2+ and Mg2+ ions with the ligand was also studied. The Schiff base and its transition metal complexes showed inhibition activity against Gram-positive bacteria (Staphylococcus aureus, Escherichia coli), Gram-negative bacteria (Pseudomonas aeruginosa) and antifungal activity against Candida albicans.Electrochemical redox reactions of the metal complexes were analyzed by cyclic voltammetry. The DNA binding properties of the complexes with HS-DNA have been explored by electron absorption spectroscopy. The cleavage reaction of the synthesized ligand and its metal complexes was monitored by gel-electrophoresis method. The nuclease activity of the above metal(II) complexes shows that the Cu(II) complex can cleave DNA effectively than ligand and other metal complexes.

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Synthesis and spectroscopic studies of homo-binuclear, alkoxo bridged homo- and hetero-tetranuclear metal complexes of a bis-N2O4 Schiff base ligand derived from ethanolamine and macroacyclic tetranaphthaldehyde

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2011.03.015 ◽

2011 ◽

Vol 79 (5) ◽

pp. 867-872 ◽

Cited By ~ 6

Author(s):

Kaan Karaoğlu ◽

Talat Baran ◽

İsmail Değirmencioğlu ◽

Kerim Serbest

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Schiff Base Ligand ◽

Spectroscopic Studies

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Synthesis, Spectral Characterization, Docking Analysis, DNA Binding/Cleavage, Antimicrobial and Cytotoxic Activity of New Dimeric Antipyrine-Schiff Base Metal Complexes

Asian Journal of Chemistry ◽

10.14233/ajchem.2019.21680 ◽

2018 ◽

Vol 31 (1) ◽

pp. 199-212 ◽

Cited By ~ 1

Author(s):

Abdel-Nasser M.A. Alaghaz ◽

Amani S. Alturiqi ◽

Reda A. Ammar ◽

Mohamed E. Zayed

Keyword(s):

Schiff Base ◽

Dna Binding ◽

Metal Complexes ◽

Cytotoxic Activity ◽

Base Metal ◽

Spectral Characterization ◽

Docking Analysis ◽

Schiff Base Metal Complexes

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Amalgamation of Novel Schiff Base Ligand and Its Transition Metal Complexes and Their Biological Activity

International Research Journal of Pure and Applied Chemistry ◽

10.9734/irjpac/2019/v18i230084 ◽

2019 ◽

pp. 1-13

Author(s):

B. Akila ◽

A. Xavier

Keyword(s):

Antibacterial Activity ◽

Schiff Base ◽

Metal Complexes ◽

Elemental Analysis ◽

Schiff Base Ligand ◽

Electronic Spectroscopy ◽

Antioxidant Properties ◽

Salmonella Typhi ◽

Metal Chelates ◽

Schiff Base Complexes

Schiff base synthesized from 2-hydroxy-1-naphthaldehyde and 2-2’ (ethylene dioxy) bis ethylenediamine (L1) and its Metal complexes, [M (II) (L)6](where M= Mn(II), Ru(III), Cu(II)and V(V) L= Schiff base moiety), have been prepared and characterized by elemental analysis, spectroscopic measurements (infrared, electronic spectroscopy, 1H-NMR, EPR and Mass spectroscopy ). Elemental analysis of the metal complexes was suggested that the stoichiometry ratio is 1:1 (metal-ligand). The electronic spectra suggest an octahedral geometry for MC1and MC2 Schiff base complexes and distorted octahedral for MC3 and MC4 complexes. The Schiff base and its metal chelates have been screened for their invitro test antibacterial activity against three bacteria, gram-positive (Staphylococcus aureus) and gram-negative (Klebsiella pheneuammonia and Salmonella typhi). Two strains of fungus (Aspergillus niger and Candida albicans). The metal chelates were shown to possess more anti fungal activity compare then antibacterial activity and antioxidant properties. The complexes are highly active than the free Schiff-base ligand.

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