Solubility determination and analysis of methimazole in different solvent systems at T = 278.15–323.15 K

2021 ◽  
Vol 342 ◽  
pp. 117546
Author(s):  
Chen Chen ◽  
Peng Zhou ◽  
Rensong Wang ◽  
Fu Zhu ◽  
Wei Sun ◽  
...  
Keyword(s):  
Solvent Systems ◽  
Solubility Determination

Solubility Determination, Model Correlation, and Solvent Effect Analysis of Nisoldipine in Different Solvent Systems at a Series of Temperature

2020 ◽  
Vol 65 (4) ◽  
pp. 1627-1635 ◽  
Author(s):  
Xia Chen ◽  
Qianqian Xu ◽  
Zhiying Liu ◽  
Xianling Zhu ◽  
Huilin Zheng ◽  
...  
Keyword(s):  
Solvent Effect ◽  
Effect Analysis ◽  
Solvent Systems ◽  
Solubility Determination ◽  
Model Correlation

Solubility Determination and Thermodynamic Modeling of N-Acetylglycine in Different Solvent Systems

2021 ◽  
Vol 66 (3) ◽  
pp. 1344-1355
Author(s):  
Ying Guo ◽  
Hui He ◽  
Haishuang Huang ◽  
Jingxuan Qiu ◽  
Jiaming Han ◽  
...  
Keyword(s):  
Thermodynamic Modeling ◽  
Solvent Systems ◽  
Solubility Determination

Solubility Determination and Thermodynamic Modeling of Edaravone in Different Solvent Systems and the Solvent Effect in Pure Solvents

2020 ◽  
Vol 65 (6) ◽  
pp. 3240-3251 ◽  
Author(s):  
Jingxuan Qiu ◽  
Haishuang Huang ◽  
Hui He ◽  
Haoyou Liu ◽  
Shen Hu ◽  
...  
Keyword(s):  
Solvent Effect ◽  
Thermodynamic Modeling ◽  
Solvent Systems ◽  
Solubility Determination

Hydrogen-Bonded Solvent Systems

1969 ◽  
Vol 67 (1_3) ◽  
pp. 168-168
Author(s):  
H. G. Hertz
Keyword(s):  
Solvent Systems ◽  
Hydrogen Bonded

VANILLINSÄURE ALS ENDPRODUKT DES STOFFWECHSELS VON ADRENALIN UND NORADRENALIN. II.

1963 ◽  
Vol 44 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Wilhelm Dirscherl ◽  
Helmut Thomas
Keyword(s):  
Rat Liver ◽  
Paper Chromatography ◽  
Column Chromatography ◽  
Vanillic Acid ◽  
Hippuric Acid ◽  
Single Spot ◽  
Solvent Systems ◽  
Perfusion Experiment ◽  
Kinetics Of

ABSTRACT Perfusion of rat liver with vanillic acid yielded only one metabolite. In paper chromatography with three different solvent systems, the substance showed the same RF-values as vanillyolglycine (3-methoxy-4-hydroxyhippuric acid) and in mixed chromatograms there was only one single spot. After separation by column chromatography, the UV- and IRspectra of the reaction product were identical with those of 3-methoxy4-hydroxy-hippuric acid. During the perfusion experiment, the kinetics of the conjugation were investigated.

OPTIMIZATION OF THIN LAYER CHROMATOGRAPHY METHODS FOR SEPARATION AND IDENTIFICATION OF ANTIDEPRESSANTS IN THEIR MIXTURE

2014 ◽  
Vol 21 (1) ◽  
pp. 11-15
Author(s):  
Daiva Kazlauskienė ◽  
Guoda Kiliuvienė ◽  
Palma Nenortienė ◽  
Giedrė Kasparavičienė ◽  
Ieva Matukaitytė
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Solvent System ◽  
Ammonia Solution ◽  
Relative Standard ◽  
Rf Values ◽  
Solvent Systems ◽  
Paroxetine Hydrochloride ◽  
Fluvoxamine Maleate ◽  
Layer Chromatography

By conducting the toxicological analysis it is meaningful to determine the analytical system that could identify simultaneously several medicinal preparations quickly and precisely. The purpose of this work was to create and validate the method of thin-layer chromatography that would be suitable to separate the components of antidepressant mixture (amitriptyline hydrochloride, paroxetine hydrochloride, sertraline hydrochloride, fluvoxamine maleate and buspirone hydrochloride) and to identify them. The system was validated with regard to the sensitivity, repetition of data, resistance and particularity. The solvent systems with potential of high separation of components in their mixture were created: acetonitrile, methanol, ammonia solution 25 percent (85:10:5); acetonitrile, methanol, ammonia solution 25 percent (75:20:5); dichlormethane, 1,4-dioxane, ammonia solution 25 percent (50:45:5); dichlormethane, 1,4-dioxane, ammonia solution 25 percent (42:55:3); trichlormethane, 1,4-dioxane, ammonia solution 25 percent (25:70:5); trichlormethane, 1,4-dioxane, ammonia solution 25 percent (60:36:4). One of the most suitable solvent systems for separation of the analyzed mixture (sertraline, amitriptyline, paroxetine, buspirone, fluvoxamine) was determined – acetonitrile, methanol, ammonia solution 25 percent (85:10:5). When this solvent system was used, the average Rf values of the analyzed compounds differed the most. Validation was conducted – the relative standard deviation (RSD, percent) of the average Rf value of the analyzed compounds varied from 0,6 to 1,8 percent and did not exceed the permissible error of 5 percent. The sensitivity of methodology was determined by assessing the intensity of the mixture’s spots on the chromatographic plate. The detection limit of buspirone was 0,0012 µg; sertraline – 0,0008 µg; amitriptyline – 0,0004 µg; fluvoxamine – 0,0004 µg; paroxetine – 0,0008 µg. The resistance of results to the changed conditions – it was determined that when the amounts of the solvents acetonitrile and methanol were increased or decreased to two milliliters, the average Rf values of the analyzed compounds did not change statistically significantly

The Influence of Extraction Solvent on the Active Principles Content of Portulaca Oleracea Native Species

2018 ◽  
Vol 69 (10) ◽  
pp. 2682-2692 ◽  
Author(s):  
Candice Popescu (Popiniuc) ◽  
Carmen Popescu ◽  
Stefan Manea ◽  
Valentin Vladut ◽  
Iulian Voicea ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Propylene Glycol ◽  
Native Species ◽  
Portulaca Oleracea ◽  
Extraction Solvent ◽  
Beneficial Effects ◽  
Solvent Systems

In this paper, a study on the influence of extraction solvent on the active principles content of purslane - Portulaca oleracea extracts was performed. For the study were used both fresh and dried plants, chopped by plant chopping machine. The following extracts were obtained and analysed in the solvent systems mentioned below: (fresh) purslane extract in Ethanol 30%, (dry) purslane extract in Ethanol 30%; (fresh) purslane extract in EtOH 70%, (dry) purslane extract in EtOH 70%; (fresh) purslane extract in propylene glycol 20%, (dry) purslane extract in propylene glycol 20%; (fresh) purslane extract in PG 100%, (dry) purslane extract in PG 100%; (fresh) purslane extract in glycerine 20%, (dry) purslane extract in glycerine 20%; (fresh) purslane extract in R glycerine, (dry) purslane extract in R glycerine; purslane hydro-alcoholic glycerine extract. The results obtained in the study performed on purslane extracts in different solvents show that the capitalization of purslane can become very profitable and with beneficial effects on economy in our country, both in terms of food and as medicinal plant.

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