Epidemiological and clinical characteristics of multiple sclerosis in paediatric population in Slovenia: A descriptive nation-wide study

2017 ◽  
Vol 18 ◽  
pp. 56-59 ◽  
Author(s):  
Neli Bizjak ◽  
Damjan Osredkar ◽  
Mirjana Perković Benedik ◽  
Saša Šega Jazbec
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Characteristics ◽  
Paediatric Population

scholarly journals Multiple sclerosis in Kenya: Demographic and clinical characteristics of a registry cohort

2021 ◽  
Vol 7 (2) ◽  
pp. 205521732110227
Author(s):  
Imran Jamal ◽  
Jasmit Shah ◽  
Peter Mativo ◽  
Juzar Hooker ◽  
Mitchell Wallin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Symptom Onset ◽  
Clinical Characteristics ◽  
Age Of Onset ◽  
Sub Saharan Africa ◽  
University Hospital ◽  
Tertiary Referral Hospital ◽  
Female Ratio ◽  
Sub Saharan ◽  
Neuro Imaging

Background Multiple Sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. There is limited literature regarding the burden of MS in sub-Saharan Africa (SSA). Objective To describe the demographic and clinical characteristics of patients with MS (PwMS) presenting to a tertiary referral hospital in Nairobi. Methods We conducted a retrospective descriptive study for PwMS presenting to Aga Khan University Hospital, Nairobi from 2008–2018. Results 99 cases met the diagnostic criteria for MS with a male to female ratio of 1:4. Majority (68.7%) of PwMS were indigenous Africans with a mean age of onset of 30.7 years. Mean duration from symptom onset to first neuro-imaging was 5.04 years. Only 33% of patients had sensory symptoms at onset whereas 54.5% had vitamin D deficiency/insufficiency. Majority (79.5%) had relapsing remitting MS (RRMS) and 56.6% were initiated on disease modifying therapy (DMT). Only 21.2% of patients on DMT were non-compliant. Patients with RRMS were more likely to be initiated on DMT at our hospital (p < 0.001). Conclusion Clinical characteristics of these patients largely resemble those of other SSA cohorts and African American patients. There was a delay between symptom onset and neuroimaging. There were also issues with DMT compliance.

scholarly journals Investigating the Relationship Between Individual and Clinical Characteristics and Executive Dysfunction of Multiple Sclerosis Individuals

2019 ◽  
pp. 114-123
Author(s):  
Maryam Pouramiri ◽  
Mojtaba Azimian ◽  
Nazila Akbarfahimi ◽  
Ebrahim Pishyareh ◽  
Samaneh Hossienzadeh
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Characteristics ◽  
Executive Dysfunction ◽  
The Relationship

Optic Neuritis

2019 ◽  
pp. 3-8
Author(s):  
Matthew J. Thurtell ◽  
Robert L. Tomsak
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Optic Neuropathy ◽  
Clinical Characteristics ◽  
Acute Onset ◽  
Visual Recovery ◽  
Imaging Findings ◽  
Treatment Trial ◽  
Management Options ◽  
Optic Neuritis Treatment Trial

Optic neuritis is the most frequent cause of acute-onset optic neuropathy in young adults and is often encountered in clinical practice. In this chapter, we begin by reviewing the cardinal signs of optic neuropathy. We review the clinical characteristics and workup of optic neuritis. We review factors that increase the risk for developing multiple sclerosis. We discuss atypical clinical and imaging findings that should prompt further evaluation for other causes of optic neuritis, such as neuromyelitis optica. Lastly, we discuss the management options for optic neuritis, with reference to the findings from the Optic Neuritis Treatment Trial, and the prognosis for visual recovery.

scholarly journals Multiple sclerosis in First Nations Canadians: A pilot comparison study

2016 ◽  
Vol 2 ◽  
pp. 205521731666609
Author(s):  
Ruth Ann Marrie ◽  
Nicholas Hall ◽  
A Dessa Sadovnick
Keyword(s):  
Multiple Sclerosis ◽  
First Nations ◽  
Clinical Characteristics ◽  
Statistical Significance ◽  
Diagnostic Delay ◽  
Psychiatric Disease ◽  
Cross Sectional ◽  
Genetic Characteristics ◽  
Standardized Interview ◽  
Observational Design

Background Genetic and clinical characteristics associated with multiple sclerosis (MS) may differ by ethnicity but few studies have evaluated whether characteristics of MS differ between individuals according to First Nations (FN) ethnicity. Objective Using a cross-sectional observational design, we compared clinical and genetic characteristics between people with MS of FN and non-FN ethnicity. Methods We recruited participants of FN ethnicity with MS. We conducted a medical records review for each participant followed by a standardized interview and drawing of blood samples. The blood underwent genetic analyses for several HLA alleles. We compared the study sample with 127 non-FN MS participants from another study conducted in the same region using the same data collection procedures. Results We included 144 participants with MS, of whom 17 (11.8%) self-identified as FN. The age of symptom onset was earlier and the diagnostic delay shorter among FN participants although these differences did not reach statistical significance. As compared to non-FN participants, FN participants with MS had increased odds of comorbid psychiatric disease (OR 5.38; 95% CI: 1.84–15.8), and were less likely to be HLA-DRB1*1501 positive (OR 0.32; 95% CI: 0.11–0.96). Conclusion Genetic and clinical characteristics of MS differ among Canadians of FN and non-FN ethnicity.

Characteristics of multiple sclerosis in aboriginals living in British Columbia, Canada

2012 ◽  
Vol 18 (9) ◽  
pp. 1239-1243 ◽  
Author(s):  
Jameelah Saeedi ◽  
Peter Rieckmann ◽  
Irene Yee ◽  
Helen Tremlett ◽  
Keyword(s):  
Multiple Sclerosis ◽  
British Columbia ◽  
Clinical Characteristics ◽  
Age At Onset ◽  
Disease Onset ◽  
Patient Characteristics ◽  
Onset Date ◽  
Disease Course ◽  
Chi Squared ◽  
Student’S T

Objectives: The objectives of this study were to identify and describe the demographic and clinical characteristics of multiple sclerosis (MS) in aboriginals in British Columbia (BC), Canada and compare these findings with non-aboriginal MS patients. Methods: This retrospective chart and database review accessed patient information from the linked BC-wide MS clinical and genetics databases. Data gathered included: demographics (age, sex and ethnicity); clinical characteristics (MS onset date, disease course and disability scores (Expanded Disability Status Scale [EDSS]). Aboriginals were identified via the database linkage augmented by physician and nurse recall. Two non-aboriginal comparator groups with definite MS were selected. Group one included all definite MS patients in the BC MS database, and group two comprised MS patients matched by sex, age at onset and initial disease course. Patient characteristics were compared using the Student’s t-test, chi-squared test, and Kaplan–Meier survival analysis was used to examine disease progression (time to sustained and confirmed EDSS 6) Results: We identified 26 aboriginals with MS, of which 19/26 (73%) were female, 23/26 (89%) had relapsing-onset MS and a mean onset age of 31.1 years. There were no significant differences between the MS aboriginals and the non-matched ( n = 5708) comparator group with respect to age, sex or disease course ( p > 0.1), However, aboriginals progressed more rapidly to EDSS 6 from disease onset ( p < 0.001) when compared with the matched and unmatched comparator groups. Conclusion: We identified a small, but important cohort of aboriginals with MS; being the largest identified to date. There was evidence of more rapid MS progression in aboriginals compared with non-aboriginals.

Temporal and Clinical Course of Multiple Sclerosis

2016 ◽  
Author(s):  
Erica Grazioli ◽  
Channa Kolb ◽  
Bianca Weinstock-Guttman
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Characteristics ◽  
Progressive Disease ◽  
Clinical Course ◽  
Disease Classification ◽  
Clinical Relapse ◽  
Resonance Imaging ◽  
Genetic Biomarkers ◽  
Active Disease ◽  
Over Time

The temporal and clinical course of multiple sclerosis is heterogeneous, varying among patients as well as over time in the same individual. Greater specificity in describing disease classification and course is important for conduct of clinical trials as well as prognosis for individual patients. This chapter reviews the results of recent consensus panels that have further defined the relapsing and progressive forms of multiple sclerosis through clarification of clinical relapse, subclinical relapse, active disease, and progressive disease. Clinical characteristics, conventional and nonconventional magnetic resonance imaging metrics, and immunologic and genetic biomarkers that can be used to predict disease severity and course are also discussed.

Frailty in ageing persons with multiple sclerosis

2020 ◽  
pp. 135245852092394
Author(s):  
Xavier Ayrignac ◽  
Catherine Larochelle ◽  
Mark Keezer ◽  
Elaine Roger ◽  
Josée Poirier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Characteristics ◽  
Frailty Index ◽  
Multivariable Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Disability Status ◽  
Socioeconomic Burden ◽  
Linear Regressions

Background: Recent progress in multiple sclerosis (MS) management has contributed to a greater life expectancy in persons with MS. Ageing with MS comes with unique challenges and bears the potential to greatly affect quality of life and socioeconomic burden. Objectives: To compare frailty in ageing persons with multiple sclerosis (pwMS) and controls; to correlate frailty with MS clinical characteristics. Methods: PwMS and controls over 50 years old were recruited in a cross-sectional study. Two validated frailty measures were assessed: the frailty index and the Fried’s phenotype. Several multiple linear regressions accounting for demographic and clinical characteristics were performed. Results: Eighty pwMS (57 females, mean age 58.5 ± 6 years old) and 37 controls (24 females, mean age 61 ± 6.5 years old) were recruited. Multivariable analysis identified significantly higher frailty index in pwMS (0.21 ± 0.12 vs 0.11 ± 0.08, p < 0.0001). Similarly, according to Fried’s phenotype, a significantly higher percentage of pwMS were frail compared to controls (28% vs 8%). In pwMS, frailty index was independently associated with expanded disability status scale (EDSS), comorbidities, education level and disease duration. Conclusion: Our results suggest that frailty can be routinely assessed in pwMS. Increased frailty in MS patients suggests that, along with MS therapeutics, a tailored multidisciplinary approach of ageing pwMS is needed.

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