Local administration of calcitriol positively influences bone remodeling and maturation during restoration of mandibular bone defects in rats

2015 ◽  
Vol 49 ◽  
pp. 14-24 ◽  
Author(s):  
Hongrui Liu ◽  
Jian Cui ◽  
Wei Feng ◽  
Shengyu Lv ◽  
Juan Du ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Bone Defects ◽  
Local Administration ◽  
Mandibular Bone

scholarly journals Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 457
Author(s):  
Milad Etemadi Sh ◽  
Nan-Chen Hsieh ◽  
Seyed Shahin Movahed Mohammadi ◽  
Shahrooz Momeni ◽  
Seyed Mohammad Razavi ◽  
...  
Keyword(s):  
Bone Density ◽  
Whole Body Vibration ◽  
Bone Defects ◽  
Whole Body ◽  
Control Group ◽  
Pulsed Ultrasound ◽  
Mandibular Bone ◽  
Body Vibration ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

Background and Objectives: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS) versus whole body vibration (WBV) on healing of mandibular bone defects. Materials and Methods: A mandibular defect was created in 66 rats. The rats were randomly divided into two groups of rats. Each group was subdivided randomly by three groups (n = 11) as follows: (I) control group, (II) treatment with LIPUS, and (III) treatment with WBV. The radiographic changes in bone density, the ratio of lamellar bone to the entire bone volume, the ratio of the newly formed bone to the connective tissue and inflammation grade were evaluated after 1 and 2 months. Results: LIPUS significantly increased the radiographic bone density change compared to the control group at the first and second month postoperatively (p < 0.01). WBV only significantly increased the bone density compared to the control group at the second month after the surgery (p < 0.01). Conclusions: Application of LIPUS and WBV may enhance the regeneration of mandibular bone defects in rats. Although LIPUS and WBV are effective in mandibular bone healing, the effects of LIPUS are faster and greater than WBV.

Histological evaluation of the healing process of autografted mandibular bone defects in rats under treatment with zoledronate

2019 ◽  
Vol 47 (11) ◽  
pp. 1779-1786
Author(s):  
Mohammad Zandi ◽  
Arash Dehghan ◽  
Ideh Talimkhani ◽  
Leila Rezaeian ◽  
Naser Mohammad Gholi Mezerji
Keyword(s):  
Healing Process ◽  
Bone Defects ◽  
Histological Evaluation ◽  
Mandibular Bone

Mandibular bone remodeling induced by dental implant

2010 ◽  
Vol 43 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Daniel Lin ◽  
Qing Li ◽  
Wei Li ◽  
Naughton Duckmanton ◽  
Michael Swain
Keyword(s):  
Bone Remodeling ◽  
Dental Implant ◽  
Mandibular Bone

scholarly journals Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Xing Wang ◽  
Helin Xing ◽  
Guilan Zhang ◽  
Xia Wu ◽  
Xuan Zou ◽  
...  
Keyword(s):  
Bone Defect ◽  
Alveolar Bone ◽  
Adult Stem Cell ◽  
Invasive Procedure ◽  
Bone Defects ◽  
Bone Tissue Regeneration ◽  
Promising Alternative ◽  
Mandibular Bone ◽  
Embryonic Origin ◽  
A Cell

Periodontal bone defects occur in a wide variety of clinical situations. Adult stem cell- and biomaterial-based bone tissue regeneration are a promising alternative to natural bone grafts. Recent evidence has demonstrated that two populations of adult bone marrow mesenchymal stromal cells (BMSCs) can be distinguished based on their embryonic origins. These BMSCs are not interchangeable, as bones preferentially heal using cells that share the same embryonic origin. However, the feasibility of tissue engineering using human craniofacial BMSCs was unclear. The goal of this study was to explore human craniofacial BMSC-based therapy for the treatment of localized mandibular defects using a standardized, minimally invasive procedure. The BMSCs’ identity was confirmed. Scanning electron microscopy, a cell proliferation assay, and supernatant detection indicated that the nHAC/PLA provided a suitable environment for aBMSCs. Real-time PCR and electrochemiluminescence immunoassays demonstrated that osteogenic markers were upregulated by osteogenic preinduction. Moreover, in a rabbit critical-size mandibular bone defect model, total bone formation in the nHAC/PLA + aBMSCs group was significantly higher than in the nHAC/PLA group but significantly lower than in the nHAC/PLA + preinduced aBMSCs. These findings demonstrate that this engineered bone is a valid alternative for the correction of mandibular bone defects.

scholarly journals Numerical design studies on a novel electrostimulative osteosynthesis system for the mandible

2017 ◽  
Vol 3 (2) ◽  
pp. 613-617 ◽  
Author(s):  
Hendrikje Raben ◽  
Christian Schmidt ◽  
Karthik Sridhar ◽  
Peer W. Kämmerer ◽  
Ursula van Rienen
Keyword(s):  
Finite Element Method ◽  
Electric Field Distribution ◽  
Bone Defects ◽  
Fracture Site ◽  
The Finite Element Method ◽  
Reconstruction Plate ◽  
Design Studies ◽  
Mandibular Bone ◽  
Numerical Design ◽  
Crucial Parameter

AbstractFractures or other major bone defects in the mandible are commonly treated by mounting a reconstruction plate at the fracture site. To avoid complications due to loosening of the implant or the fixation screws, electrical stimulation presents a possibility to accelerate bone healing. The aim of this study was to investigate different combinations of activated electrodes and plate designs regarding their feasibility for electrostimulation of the mandibular bone. The electric field distribution for multiple implant designs was computed using the finite element method. The results suggest that the electrode insulation renders a crucial parameter, which influences substantially the stimulation impact and its power consumption.

scholarly journals Repair of Rat Mandibular Bone Defects by Alveolar Osteoblasts in a Novel Plasma-Derived Albumin Scaffold

2010 ◽  
Vol 16 (4) ◽  
pp. 1179-1187 ◽  
Author(s):  
Lorena Gallego ◽  
Luis Junquera ◽  
Eva García ◽  
Verónica García ◽  
María Álvarez-Viejo ◽  
...  
Keyword(s):  
Bone Defects ◽  
Mandibular Bone
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