scholarly journals FDA-Approved Bone Grafts and Bone Graft Substitute Devices in Bone Regeneration

2021 ◽  
pp. 112466
Author(s):  
Cassidy E. Gillman ◽  
Ambalangodage C. Jayasuriya
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Grafts ◽  
Bone Graft Substitute

scholarly journals Systemic Administration of PTH Supports Vascularization in Segmental Bone Defects Filled with Ceramic-Based Bone Graft Substitute

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2058
Author(s):  
Holger Freischmidt ◽  
Jonas Armbruster ◽  
Emma Bonner ◽  
Thorsten Guehring ◽  
Dennis Nurjadi ◽  
...  
Keyword(s):  
Bone Graft ◽  
Donor Site ◽  
Bone Grafts ◽  
Bone Graft Substitute ◽  
Therapeutic Strategies ◽  
Care Providers ◽  
Sprague Dawley ◽  
Duration Of Treatment ◽  
Autologous Bone ◽  
Autologous Bone Grafts

Non-unions continue to present a challenge to trauma surgeons, as current treatment options are limited, duration of treatment is long, and the outcome often unsatisfactory. Additionally, standard treatment with autologous bone grafts is associated with comorbidity at the donor site. Therefore, alternatives to autologous bone grafts and further therapeutic strategies to improve on the outcome and reduce cost for care providers are desirable. In this study in Sprague–Dawley rats we employed a recently established sequential defect model, which provides a platform to test new potential therapeutic strategies on non-unions while gaining mechanistic insight into their actions. The effects of a combinatorial treatment of a bone graft substitute (HACaS+G) implantation and systemic PTH administration was assessed by µ-CT, histological analysis, and bio-mechanical testing and compared to monotreatment and controls. Although neither PTH alone nor the combination of a bone graft substitute and PTH led to the formation of a stable union, our data demonstrate a clear osteoinductive and osteoconductive effect of the bone graft substitute. Additionally, PTH administration was shown to induce vascularization, both as a single adjuvant treatment and in combination with the bone graft substitute. Thus, systemic PTH administration is a potential synergistic co-treatment to bone graft substitutes.

scholarly journals A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pierre Tournier ◽  
Jérôme Guicheux ◽  
Arnaud Paré ◽  
Aymeric Maltezeanu ◽  
Thibaut Blondy ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Grafts ◽  
Ease Of Use ◽  
Osteogenic Potential ◽  
Allogeneic Bone ◽  
Promising Alternative ◽  
Allogenic Bone

AbstractIn skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. In this study, the regenerative potential of this paste was assessed and compared to its clinically used precursor form allogenic bone particles. Compared to the particular bone graft, the bone paste allowed better attachment of human mesenchymal stromal cells and their commitment towards the osteoblastic lineage, and it induced a pro-regenerative phenotype of human monocytes/macrophages. The bone paste also supported bone healing in vivo in a guide bone regeneration model and, more interestingly, exhibited a substantial bone-forming ability when implanted in a critical-size defect model in rat calvaria. Thus, these findings indicate that this novel partially demineralized allogeneic bone paste that combines substantial bone healing properties and rapid and ease-of-use may be a promising alternative to allogeneic bone grafts for bone regeneration in several clinical contexts of oral and maxillofacial bone grafting.

scholarly journals Potential Use of Eggshell as Bone Graft Compared with Bovine for Bone Defect: A Systematic Review Study

2021 ◽  
Vol 9 (F) ◽  
pp. 470-473
Author(s):  
Hanif Andhika Wardhana ◽  
Mujaddid Idulhaq ◽  
Rhyan Darma Saputra ◽  
Rieva Ermawan ◽  
Musa Fasa Roshada
Keyword(s):  
Systematic Review ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Clinical Performance ◽  
Bone Grafts ◽  
Bone Tissue Regeneration ◽  
In Vivo Studies ◽  
Bovine Bone

Background : The use of Bone Graft in the management of Bone Defect is a challenge in the world of orthopedics. Recently, eggshell containing hydroxyapatite has become a new hope in the use of an economical and efficient bone graft in the treatment of bone defects. The aim of this systematic review was to explore the available literature on the clinical performance of eggshells as bone grafts in guided bone regeneration. Method : Two databases (PubMed and Cochrane) were searched from January 2010 to September 2020. Clinical trials using eggshells as bone grafts were included in the review. Animal and in vivo studies were excluded from the review. Results : A total of 202 studies were taken, then screened and 15 studies finally included. Clinical and radiological evaluations show complete recovery after the procedure. Comparison with synthetic hydroxyapatite shows similar healing characteristics. Conclusion : Eggshell compared to bovine showed no difference in bone healing. Within the limitations of the included studies, eggshells can be used safely and efficiently in integrated bone regeneration procedures. Keywords: Bone tissue regeneration; eggshell; bovine; bone defect; bone graft  

Flexural Rigidity of Laboratory and Surgical Substitutes for Human Fibular Bone Grafts

1998 ◽  
Vol 02 (04) ◽  
pp. 267-272 ◽  
Author(s):  
Anneliese D. Heiner ◽  
Robert A. Poggie ◽  
Thomas D. Brown
Keyword(s):  
Bone Graft ◽  
Relative Density ◽  
Empirical Data ◽  
Flexural Rigidity ◽  
Experimental Studies ◽  
Bone Grafts ◽  
Bone Graft Substitute ◽  
Porous Solids ◽  
Fibular Graft ◽  
Porous Tantalum

The purpose of this study was to measure flexural rigidity of two new synthetic fibular graft substitutes, and compare these data to the flexural rigidity of natural human fibulas. These substitutes were composite fiberglass surrogate fibulas, to be used in laboratory experimental studies, and porous tantalum cylinders, being researched as a bone graft substitute. Ten fiberglass surrogate fibulas and 13 porous tantalum rods were tested in a 4-point bending fixture. Both types of fibular graft substitute had flexural rigidities comparable to natural human fibulas. The fiberglass surrogate fibulas had much less inter-specimen variability in flexural rigidity than did the natural human fibulas (6%/10% vs. 36%/52% for A-P/M-L directions). The surrogate fibula is therefore appropriate for use in laboratory experimental studies of fibular grafts which will undergo bending. The flexural rigidity of the porous tantalum rods increased with relative density to the 1.2 power, as suggested by theory and empirical data for porous solids; thus, porous tantalum density and rod diameter can be varied to obtain the desired flexural rigidity.

scholarly journals Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone‐graft substitute for accelerated craniofacial bone regeneration

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Dong Keon Lee ◽  
Mi-Ran Ki ◽  
Euy Hyun Kim ◽  
Chang-Joo Park ◽  
Jae Jun Ryu ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Bone Grafting ◽  
Drug Carrier ◽  
Bone Graft Substitute ◽  
Tissue Growth ◽  
Bone Morphogenetic Protein 2 ◽  
Therapeutic Drug

Abstract Background Bioceramic β-tricalcium phosphate (β-TCP) is used as a bone-grafting material and a therapeutic drug carrier for treatment of bone defects in the oral and maxillofacial regions due to the osteoconductivity and biocompatibility. However, the low mechanical strength and limited osteoinductivity of β-TCP agglomerate restrict bone regenerating performance in clinical settings. Methods Herein, a biomimetic composite is proposed as a bone morphogenetic protein-2 (BMP-2)-delivering bone graft substitute to achieve a robust bone grafting and augmented bone regeneration. Results The sequential processes of brown algae-inspired biosilicification and collagen coating on the surface of β-TCP enable the effective incorporation of BMP-2 into the coating layer without losing its bioactivity. The sustained delivery of BMP-2 from the biosilicated collagen and β-TCP composites promoted in vitro osteogenic behaviors of pre-osteoblasts and remarkedly accelerated in vivo bone regeneration within a rat calvarial bone defect. Conclusions Our multicomposite bone substitutes can be practically applied to improve bone tissue growth in bone grafting applications with further expansion to general bone tissue engineering.

scholarly journals The Use of Bone Grafts, Bone Graft Substitutes, and Orthobiologics for Osseous Healing in Foot and Ankle Surgery

2019 ◽  
Vol 4 (3) ◽  
pp. 247301141984901 ◽  
Author(s):  
Jonathan R. Peterson ◽  
Fangyu Chen ◽  
Eugene Nwankwo ◽  
Travis J. Dekker ◽  
Samuel B. Adams
Keyword(s):  
Bone Graft ◽  
Donor Site ◽  
Bone Grafts ◽  
Bone Graft Substitute ◽  
Autologous Bone Graft ◽  
Donor Site Morbidity ◽  
Foot And Ankle ◽  
Level Of Evidence ◽  
Ankle Surgery ◽  
Bone Graft Substitutes

Achieving fusion in osseous procedures about the foot and ankle presents unique challenges to the surgeon. Many patients have comorbidities that reduce osseous healing rates, and the limited space and high weightbearing demand placed on fusion sites makes the choice of bone graft, bone graft substitute, or orthobiologic agent of utmost importance. In this review, we discuss the essential characteristics of grafts, including their osteoconductive, osteoinductive, osteogenic, and angiogenic properties. Autologous bone graft remains the gold standard and contains all these properties. However, the convenience and lack of donor site morbidity of synthetic bone grafts, allografts, and orthobiologics, including growth factors and allogenic stem cells, has led to these being used commonly as augments. Level of Evidence: Level V, expert opinion.

scholarly journals Multiple Porous Synthetic Bone Graft Comprising Engineered Micro-Channel for Drug Carrier and Bone Regeneration

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5320
Author(s):  
Chun-Sik Bae ◽  
Seung-Hyun Kim ◽  
Taeho Ahn ◽  
Yeonji Kim ◽  
Se-Eun Kim ◽  
...  
Keyword(s):  
Sustained Release ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Grafts ◽  
Channel Structure ◽  
Bovine Bone ◽  
Micro Channel ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Different Types

Due to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements. In this study, two different types of bone grafts were tested for their drug carrying abilities along with their osteogenic properties. Two different types of alendronate-loaded bone grafts, Bio-Oss (bovine bone graft) and InRoad (biphasic synthetic bone graft) were observed to see how different concentrations of alendronate would affect the sustained release to enhance osteogenesis. In this study, defected ovariectomize-induced osteoporotic rat calvarias were observed for 28 days with three different concentrations of alendronate (0 mg, 1 mg, 5 mg) for both Bio-Oss and InRoad. A higher concentration (5 mg) allowed for a more controlled and sustained release throughout the 28-day comparison to those of lower concentrations (0 mg, 1 mg). When comparing Bio-Oss and InRoad through histology and Micro-CT, InRoad showed higher enhancement in osteogenesis. Through this study, it was observed that alendronate not only brings out robust osteogenesis with InRoad bone grafts, but also enhances bone regeneration in an alendronate-concentration-dependent manner. The combination of higher concentration of alendronate and multiple porous bone graft containing internal micro-channel structure of InRoad resulted in higher osteogenesis with a sustained release of alendronate.

Bone regeneration through facile binding of bone graft substitute particles using mussel adhesive protein

2014 ◽  
Vol 31 ◽  
pp. S53
Author(s):  
Hyung Joon Cha ◽  
Bong-Hyuk Choi ◽  
Hogyun Cheong ◽  
Yun Kee Jo ◽  
Jin-Soo Ahn ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Graft Substitute ◽  
Adhesive Protein ◽  
Mussel Adhesive Protein ◽  
Mussel Adhesive

scholarly journals Preparation and Characterization of Surface Heat Sintered Nanohydroxyapatite and Nanowhitlockite Embedded Poly (Lactic-co-glycolic Acid) Microsphere Bone Graft Scaffolds: In Vitro and in Vivo Studies

2020 ◽  
Vol 21 (2) ◽  
pp. 528 ◽  
Author(s):  
Gils Jose ◽  
K.T. Shalumon ◽  
Han-Tsung Liao ◽  
Chang-Yi Kuo ◽  
Jyh-Ping Chen
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Cellular Response ◽  
Glycolic Acid ◽  
Bone Grafts ◽  
Osteogenic Potential ◽  
Regeneration Ability ◽  
Physico Chemical

In the context of using bone graft materials to restore and improve the function of damaged bone tissues, macroporous biodegradable composite bone graft scaffolds have osteoinductive properties that allow them to provide a suitable environment for bone regeneration. Hydroxyapatite (HAP) and whitlockite (WLKT) are the two major components of hard tissues such as bone and teeth. Because of their biocompatibility and osteoinductivity, we synthesized HAP (nHAP) and WLKT nanoparticles (nWLKT) by using the chemical precipitation method. The nanoparticles were separately incorporated within poly (lactic-co-glycolic acid) (PLGA) microspheres. Following this, the composite microspheres were converted to macroporous bone grafts with sufficient mechanical strength in pin or screw shape through surface sintering. We characterized physico-chemical and mechanical properties of the nanoparticles and composites. The biocompatibility of the grafts was further tested through in vitro cell adhesion and proliferation studies using rabbit bone marrow stem cells. The ability to promote osteogenic differentiation was tested through alkaline phosphate activity and immunofluorescence staining of bone marker proteins. For in vivo study, the bone pins were implanted in tibia bone defects in rabbits to compare the bone regeneration ability though H&E, Masson’s trichrome and immunohistochemical staining. The results revealed similar physico-chemical characteristics and cellular response of PLGA/nHAP and PLGA/nWLKT scaffolds but the latter is associated with higher osteogenic potential towards BMSCs, pointing out the possibility to use this ceramic nanoparticle to prepare a sintered composite microsphere scaffold for potential bone grafts and tissue engineered implants.

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