Oseltamivir phosphate loaded pegylated-Eudragit nanoparticles for lung cancer therapy: Characterization, prolonged release, cytotoxicity profile, apoptosis pathways and in vivo anti-angiogenic effect by using CAM assay

2022 ◽  
Vol 139 ◽  
pp. 104251
Gülsel Yurtdaş-Kırımlıoğlu ◽  
Kadri Güleç ◽  
Şennur Görgülü ◽  
Hülya Tuba Kıyan
2014 ◽  
Vol 31 (7) ◽  
pp. 656-657
V. Jeannot ◽  
S. Mazzaferro ◽  
J. Lavaud ◽  
V. Josserand ◽  
M. Guidetti ◽  

2019 ◽  
Vol 14 (1) ◽  
Jinyuan He ◽  
Chulian Gong ◽  
Jie Qin ◽  
Mingan Li ◽  
Shaohong Huang

Abstract Current cancer therapy usually succumbs to many extracellular and intracellular barriers, among which untargeted distribution and multidrug resistance (MDR) are two important difficulties responsible for poor outcome of many drug delivery systems (DDS). Here, in our study, the dilemma was addressed by developing a cancer cell membrane (CCM)-coated silica (SLI) nanoparticles to co-deliver miR495 with doxorubicin (DOX) for effective therapy of lung cancer (CCM/SLI/R-D). The homologous CCM from MDR lung cancer cells (A549/DOX) was supposed to increase the tumor-homing property of the DDS to bypass the extracellular barriers. Moreover, the MDR of cancer cells were conquered through downregulation of P-glycoprotein (P-gp) expression using miR495. It was proved that miR495 could significantly decrease the expression of P-gp which elevated intracellular drug accumulation in A549/DOX. The in vitro and in vivo results exhibited that CCM/SLI/R-D showed a greatly enhanced therapeutic effect on A549/DOX, which was superior than applying miR495 or DOX alone. The preferable effect of CCM/SLI/R-D on conquering the MDR in lung cancer provides a novel alternative for effective chemotherapy of MDR cancers.

Nanomedicine ◽  
2019 ◽  
Vol 14 (18) ◽  
pp. 2461-2479
Nayra M Kamel ◽  
Maged W Helmy ◽  
Magda W Samaha ◽  
Doaa Ragab ◽  
Ahmed O Elzoghby

Aim: Multicompartmental lipid–protein nanohybrids (MLPNs) were developed for combined delivery of the anticancer drugs tretinoin (TRE) and genistein (GEN) as synergistic therapy of lung cancer. Materials & methods: The GEN-loaded lipid core was first prepared and then coated with TRE-loaded zein shell via nanoprecipitation. Results: TRE/GEN-MLPNs demonstrated a size of 154.5 nm. In situ ion pair formation between anionic TRE and the cationic stearyl amine improved the drug encapsulation with enhanced stability of MLPNs. TRE/GEN-coloaded MLPNs were more cytotoxic against A549 cancer cells compared with combined free GEN/TRE. In vivo, lung cancer bearing mice treated with TRE/GEN-MLPNs displayed higher apoptotic caspase activation compared with mice-treated free combined GEN/TRE. Conclusion: TRE/GEN-MLPNs might serve as a promising parenteral nanovehicles for lung cancer therapy.

2019 ◽  
Vol 21 (7) ◽  
Changliang Chi ◽  
Fuwei Li ◽  
Huibo Liu ◽  
Shiyun Feng ◽  
Yanjun Zhang ◽  

Mei Jiang ◽  
Yuchen Lin ◽  
Xiaocui Fang ◽  
Mingpeng Liu ◽  
Lilusi Ma ◽  

A novel delivery system for cisplatin based on electrostatics-mediated assemblies of gold nanoclusters and PEGylated cationic peptide was constructed. The constructed cisplatin@GC-pKs showed much enhanced anti-tumor activity for lung cancer therapy.

2015 ◽  
Vol 34 (2) ◽  
pp. 291-301 ◽  
Dalit Landesman-Milo ◽  
Srinivas Ramishetti ◽  
Dan Peer

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