scholarly journals Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy

2015 ◽  
Vol 11 (5) ◽  
pp. 1133-1140 ◽  
Author(s):  
Mark E. Lobatto ◽  
Claudia Calcagno ◽  
Maarten J. Otten ◽  
Antoine Millon ◽  
Sarayu Ramachandran ◽  
...  
Keyword(s):  
Pharmaceutical Development ◽  
Preclinical Evaluation ◽  
Anti Inflammatory

scholarly journals The main stages of pharmaceutical development of emulgel “Probioskin”

2021 ◽  
pp. 75-84
Author(s):  
Alina Soloviova ◽  
Olha Kaliuzhnaia ◽  
Oksana Strilets ◽  
Dmytro Lytkin ◽  
Olga Goryacha
Keyword(s):  
Microbial Contamination ◽  
Study Drug ◽  
Central Research ◽  
Reference Drug ◽  
Pharmaceutical Development ◽  
Dermatological Diseases ◽  
Biological Studies ◽  
Pharmacological Studies ◽  
Complex Preparation ◽  
Anti Inflammatory

The aim. To conduct research on the pharmaceutical development of a complex preparation with probiotic “Probioskin” in the form of an emulgel for the treatment of infectious and inflammatory dermatological diseases. Methods. Uniformity was determined by visual inspection of the test samples using an XSP-128 ULAB biological microscope. The study of the rheological properties of the samples was carried out using a Rheolab QC rheovisosimeter (Anton Paar, Austria) using a system of coaxial cylinders C-CC27 / SS. Microbiological studies and biotesting on a biological model of ciliates were carried out in aseptic conditions of a laminar box (biological safety cabinet AC2-4E1 “Esco”, Indonesia) of the Department of Biotechnology of the National University of Pharmacy (completely). Pharmacological studies (determination of the parameters of acute toxicity and anti-inflammatory properties on the model of acute exudative inflammation of the foot in rats caused by zymosan and carrageenan) were carried out on the basis of the Central Research Laboratory of the NUPh. Results. On the basis of the complex of the carried out studies, the composition of the complex preparation for skin use “Probioskin” was substantiated. The analysis of the microbiological purity of the developed agent during the proposed shelf life of 12 months showed that the drug meets the requirements of the State Pharmacopoeia Monograph for cutaneous application in terms of the level of microbial contamination by foreign microflora. The complex of pharmacological studies carried out indicates that the drug “Probioskin” can be attributed to group 6 of class and classified as a “relatively harmless” agent. The study of the anti-inflammatory effect of the drug indicates that the drug exhibits moderate anti-inflammatory properties. Under the condition of zymosan inflammation, which is associated with the activation of leukotrienes as inflammatory mediators, the average antiexudative activity of the drug is 33 %. The drug has a moderate antiexudative effect under the condition of carrageenan edema, which is evidence of its effect on exudation processes mediated by prostaglandins. The mean AEA of the study drug was 24 %. Conclusions. For the development of a soft preparation for skin use for the treatment of infectious and inflammatory dermatological diseases, the following components have been selected: active – lactobacilli, dexpanthenol, lactic acid; auxiliary - propylene glycol, peach oil, polysorbate-80, aristophlex, tocopherol, the concentration of which was substantiated on the basis of a complex of organoleptic, physicochemical, pharmacological, microbiological and biological studies. It has been experimentally established that the “Probioskin” emulgel meets the requirements of the SPhU in terms of the level of microbial contamination by extraneous microflora. Pharmacological studies allow the drug to be classified as “relatively harmless” with anti-inflammatory properties at a level not lower than the reference drug

scholarly journals Preclinical evaluation of antioxidant, anti-inflammatory, cytotoxic and lipid-lowering properties of a nutraceutical from Curcuma longa cultivated in Cuba

2019 ◽  
Vol 7 (6) ◽  
pp. 319-325
Author(s):  
Valdes-Gonzalez T ◽  
Infante-Burzac JF ◽  
Arteche-Garcia J ◽  
Oliva-Hernandez R ◽  
Farinas-Medina M ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Lipid Lowering ◽  
Preclinical Evaluation ◽  
Anti Inflammatory

Curcumin and n-acetylcysteine cocrystal produced with supercritical solvent: characterization, solubility, and preclinical evaluation of antinociceptive and anti-inflammatory activities

2022 ◽  
Author(s):  
Alessandro R. Paulazzi ◽  
Bianca O. Alves ◽  
Gabriela A. L. Zilli ◽  
Aline E. dos Santos ◽  
Fernanda Petry ◽  
...  
Keyword(s):  
Preclinical Evaluation ◽  
Supercritical Solvent ◽  
Anti Inflammatory

scholarly journals Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention

2004 ◽  
Vol 109 (3) ◽  
pp. 322-328 ◽  
Author(s):  
Alfonso Catalano ◽  
Laura Graciotti ◽  
Luciana Rinaldi ◽  
Giorgia Raffaelli ◽  
Sabrina Rodilossi ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Preclinical Evaluation ◽  
Inflammatory Agent ◽  
Anti Inflammatory

scholarly journals Preclinical evaluation of antinociceptive and anti-inflammatory effects of aqueous plant extract of Pedalium murex Linn.

2016 ◽  
Vol 03 (02) ◽  
pp. 57-62
Author(s):  
Sudhakar Pachiappan ◽  
Vinoth P Veeramani ◽  
Jothi M Cheenakesavalu ◽  
Anand Ramasamy
Keyword(s):  
Plant Extract ◽  
Preclinical Evaluation ◽  
Pedalium Murex ◽  
Anti Inflammatory

scholarly journals Multicomponent Domino Reaction in the Asymmetric Synthesis of Cyclopentan[c]pyran Core of Iridoid Natural Products

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1308
Author(s):  
Alejandro Manchado ◽  
Victoria Elena Ramos ◽  
David Díez ◽  
Narciso M. Garrido
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Asymmetric Synthesis ◽  
Heteronuclear Nmr ◽  
Domino Reaction ◽  
One Pot ◽  
Pharmaceutical Development ◽  
New Drug ◽  
Anti Inflammatory ◽  
Pharmaceutical Properties

The asymmetric synthesis of a compound with the cyclopentan[c]pyran core of iridoid natural products in four steps and 40% overall yield is reported. Our methodology includes a one-pot tandem domino reaction which provides a trisubstituted cyclopentane with five new completely determined stereocenters, which were determined through 2D homo and heteronuclear NMR and n.O.e. experiments on different compounds specially designed for this purpose, such as a dioxane obtained from a diol. Due to their pharmaceutical properties, including sedative, analgesic, anti-inflammatory, CNS depressor or anti-conceptive effects, this methodology to produce the abovementioned iridoid derivatives, is an interesting strategy in terms of new drug discovery as well as pharmaceutical development.

Preclinical evaluation of the urokinase receptor-derived peptide UPARANT as an anti-inflammatory drug

2017 ◽  
Vol 66 (8) ◽  
pp. 701-709 ◽  
Author(s):  
Serena Boccella ◽  
Elisabetta Panza ◽  
Liliana Lista ◽  
Carmela Belardo ◽  
Angela Ianaro ◽  
...  
Keyword(s):  
Urokinase Receptor ◽  
Inflammatory Drug ◽  
Preclinical Evaluation ◽  
Anti Inflammatory

Bioisosteric Fluorine in the Clandestine Design of Synthetic Cannabinoids

2015 ◽  
Vol 68 (1) ◽  
pp. 4 ◽  
Author(s):  
Shane M. Wilkinson ◽  
Samuel D. Banister ◽  
Michael Kassiou
Keyword(s):  
Law Enforcement ◽  
Medicinal Chemistry ◽  
Scientific Literature ◽  
Synthetic Cannabinoids ◽  
Health Concerns ◽  
Pharmaceutical Development ◽  
Preclinical Evaluation ◽  
The Past ◽  
Pharmacological Data ◽  
Patent Literature

Over the past decade, a plethora of indole-based synthetic cannabinoids (SCs) have emerged with their structures clearly inspired by scientific literature. Their structures continually evolve to elude detection by law enforcement and circumvent finite scheduling laws. The latest generation of SCs follow patent literature that encompasses a bioisosteric fluorine-for-hydrogen replacement commonly applied in medicinal chemistry. Unlike traditional pharmaceutical development, where rigorous preclinical evaluation is completed before human administration, these SCs are distributed for intended recreational consumption with little-to-no pharmacological data known. This highlight explores the evolution of SCs to this latest generation of fluorinated SCs where accumulating evidence indicates increased health concerns.

Mass spectrometry characterization of Commiphora leptophloeos leaf extract and preclinical evaluation of toxicity and anti-inflammatory potential effect

2021 ◽  
Vol 264 ◽  
pp. 113229
Author(s):  
Renato Dantas-Medeiros ◽  
Allanny Alves Furtado ◽  
Ana C. Zanatta ◽  
Manoela Torres-Rêgo ◽  
Estela Mariana Guimarães Lourenço ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Leaf Extract ◽  
Potential Effect ◽  
Preclinical Evaluation ◽  
Anti Inflammatory

scholarly journals Preclinical Evaluation of Intestinal Anti-Inflammatory/Analgesic Properties and Phase I Clinical Trial of a New PPAR Agonist Ged-0507-34-Levo

2011 ◽  
Vol 140 (5) ◽  
pp. S-515 ◽  
Author(s):  
Christel Rousseaux ◽  
Caroline Dubuquoy ◽  
Noura. El-Jamal ◽  
Silvia Speca ◽  
Salvatore Bellinvia ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase I ◽  
Phase I Clinical Trial ◽  
Ppar Agonist ◽  
Preclinical Evaluation ◽  
Anti Inflammatory
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