One-pot synthesis of pH-sensitive polymeric nanoparticles and controlled drug release study

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.

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One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin–disulfide–methoxy polyethylene glycol for tumor therapy

Journal of Materials Chemistry B ◽

10.1039/c7tb02817b ◽

2018 ◽

Vol 6 (1) ◽

pp. 39-43 ◽

Cited By ~ 29

Author(s):

Xiao Duan ◽

Ting Bai ◽

Junjie Du ◽

Jie Kong

Keyword(s):

Polyethylene Glycol ◽

Drug Release ◽

Tumor Therapy ◽

Controlled Drug Release ◽

One Pot ◽

One Pot Synthesis ◽

Amphiphilic Drug ◽

Methoxy Polyethylene Glycol ◽

Accumulated Toxicity

We present a novel glutathione-responsive amphiphilic drug self-delivery (DSD) micelle with one-pot synthesis to synergistically address the problems of controlled drug release, degradability, drug tracing and in vivo accumulated toxicity.

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Preparation of a Thermo-Sensitive Poly(N-Acryloyl Alanine Methyl Ester) for Controlled Drug Release

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.306-307.675 ◽

2011 ◽

Vol 306-307 ◽

pp. 675-678 ◽

Cited By ~ 1

Author(s):

Kui Lin Deng ◽

Hai Bin Zhong ◽

Yu’e Shi ◽

Jian Zuo ◽

Chun Yan Jiang ◽

...

Keyword(s):

Methyl Ester ◽

Drug Release ◽

Aqueous Solutions ◽

Radical Polymerization ◽

Pure Water ◽

Controlled Drug Release ◽

Drug Release Study ◽

H Nmr ◽

Release Study ◽

Thermo Sensitivity

A novel thermo-sensitive poly(N-acryloyl alanine methyl ester) (PAAME) was synthesized by radical polymerization. The structures of the corresponding monomer and polymer have been confirmed by1H NMR and FTIR measurements. The thermo-sensitivity of PAAME was investigated by measuring their lower critical solution temperatures (LCST) in pure water and at different pH solution. The results indicated that PAAME exhibited a reversible thermo-sensibility in its aqueous solutions at 17.7 °C. The drug release study showed that 72% caffeine was released from hydrogel at 37 °C after 6 hours, while more than 94% caffeine was gradually diffused into the medium at 18 °C.

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Synthesis and characterization of semi-conductive nanocomposite based on hydrolyzed collagen and in vitro electrically controlled drug release study

Polymer ◽

10.1016/j.polymer.2015.06.050 ◽

2015 ◽

Vol 76 ◽

pp. 287-294 ◽

Cited By ~ 14

Author(s):

Ali Pourjavadi ◽

Mohadeseh Doroudian

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Synthesis And Characterization ◽

Drug Release Study ◽

Hydrolyzed Collagen ◽

Release Study

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Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Journal of Biomaterials Applications ◽

10.1177/0885328220952594 ◽

2020 ◽

pp. 088532822095259

Author(s):

Ke Ma ◽

Yongbin Cheng ◽

Xinran Wei ◽

Daijun Chen ◽

Xiaoli Zhao ◽

...

Keyword(s):

Drug Release ◽

Fluorescence Imaging ◽

Colloidal Stability ◽

Drug Loading ◽

Tumor Therapy ◽

Chitosan Nanoparticles ◽

Fluorescence Emission ◽

Controlled Drug Release ◽

Ph Sensitive ◽

One Pot

In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.

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