This two-part series presents an integrative model for understanding and treating depression, encompassing the biological, psychological, social, and spiritual levels of the human being. Major depressive disorder may be seen as a dysregulated form of an adaptive response. Theories regarding the adaptive functions of depression drawn from psychology, evolutionary biology, ethology, neuroendocrinology, dream research, the philosophies of naturopathy and homeopathy, and the spiritual traditions of the Native Americans and other cultures are reviewed and synthesized. This model provides the basis for the rational application of a variety of complementary and conventional therapies.
Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder