Long-term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons, following global cerebral ischemia and neuroprotective melatonin treatment, in rats

2008 ◽  
Vol 448 (1) ◽  
pp. 148-152 ◽  
Author(s):  
Dafne García-Chávez ◽  
Ignacio González-Burgos ◽  
Graciela Letechipía-Vallejo ◽  
Elisa López-Loeza ◽  
Gabriela Moralí ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Cerebral Ischemia ◽  
Pyramidal Neurons ◽  
Global Cerebral Ischemia ◽  
Melatonin Treatment ◽  
Term Evaluation

Long-term study of dendritic spines from hippocampal CA1 pyramidal cells, after neuroprotective melatonin treatment following global cerebral ischemia in rats

2007 ◽  
Vol 423 (2) ◽  
pp. 162-166 ◽  
Author(s):  
Ignacio González-Burgos ◽  
Graciela Letechipía-Vallejo ◽  
Elisa López-Loeza ◽  
Gabriela Moralí ◽  
Miguel Cervantes
Keyword(s):  
Cerebral Ischemia ◽  
Dendritic Spines ◽  
Pyramidal Cells ◽  
Global Cerebral Ischemia ◽  
Melatonin Treatment ◽  
Term Study ◽  
Ca1 Pyramidal Cells ◽  
Long Term Study ◽  
Hippocampal Ca1

Exploring the Role of Remote Ischemic Preconditioning In Long Term Cognitive Impairment after Global Ischemia-Reperfusion-Induced Vascular Dementia in Mice

2020 ◽  
Author(s):  
Amteshwar Singh Jaggi
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Vascular Dementia ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion ◽  
Remote Ischemic Preconditioning ◽  
Global Cerebral Ischemia ◽  
Cerebral Ischemic ◽  
The Brain

Aim: The aim of the present study is to explore the neuroprotective effects of remote ischemic preconditioning in long term cognitive impairment after global cerebral ischemia induced-vascular dementia in mice. Material and methods: The mice were subjected to global cerebral ischemia by occluding the bilateral common carotid arteries for 12 minutes followed by the 24 hours of the reperfusion. The remote ischemic preconditioning stimulus was delivered in the form of 4 cycles of ischemia/reperfusion for 5 minutes each. The cerebral ischemic injury induced-long term cognitive impairment-related learning and memory alterations was assessed using morris water maze, the motor performances of the animals were evaluated using rota-rod test and neurological severity score. The cerebral infract size of the brain were quantified using triphenyltetrazolium chloride staining. Results: Global cerebral ischemia causes long term memory impairment, decreases motor performances and increases the brain infract size in animals. The delivery of remote ischemic preconditioning stimulus significantly abolished the long-term cognitive impairment and ameliorates the motor performances as well as cerebral infract size in brain. Conclusion: The remote ischemic preconditioning mediates neuro protection against global cerebral ischemic injury induced long-term cognitive impairment.

An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia

2006 ◽  
Vol 34 (8) ◽  
pp. 2194-2200 ◽  
Author(s):  
Ruediger R. Noppens ◽  
Michael Christ ◽  
Ansgar M. Brambrink ◽  
Ines P. Koerner ◽  
Axel Heimann ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Hypertonic Saline ◽  
Hydroxyethyl Starch ◽  
Global Cerebral Ischemia ◽  
Term Outcome ◽  
Long Term Outcome

Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats

2018 ◽  
Vol 337 ◽  
pp. 173-182 ◽  
Author(s):  
Jacqueline Godinho ◽  
Rúbia Maria Weffort de Oliveira ◽  
Anacharis Babeto de Sa-Nakanishi ◽  
Cristiano Correia Bacarin ◽  
Claudia Hitomi Huzita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Ischemia ◽  
Ethyl Acetate ◽  
Ethyl Acetate Fraction ◽  
Global Cerebral Ischemia ◽  
Retrograde Memory

Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia

2010 ◽  
Vol 57 (7) ◽  
pp. 762-773 ◽  
Author(s):  
Johanna Gutiérrez-Vargas ◽  
John Fredy Castro-Álvarez ◽  
David Velásquez-Carvajal ◽  
Maria Natalia Montañez-Velásquez ◽  
Ángel Céspedes-Rubio ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Spatial Memory ◽  
Global Cerebral Ischemia ◽  
Rac1 Activity ◽  
Neuronal Pathology

scholarly journals Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Mary L Phillips ◽  
Holly Anne Robinson ◽  
Lucas Pozzo-Miller
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Social Memory ◽  
Autism Spectrum ◽  
Contributing Factors ◽  
Knockout Mouse Model ◽  
And Behavior ◽  
Social Memories

Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has deficits in social memory. Long-term excitation of mPFC-projecting vHIP neurons in wild-type mice impaired social memory, whereas their long-term inhibition in Rett mice rescued social memory deficits. The extent of social memory improvement was negatively correlated with vHIP-evoked responses in mPFC slices, on a mouse-per-mouse basis. Acute manipulations of the vHIP-mPFC projection affected social memory in a region and behavior selective manner, suggesting that proper vHIP-mPFC signaling is necessary to recall social memories. In addition, we identified an altered pattern of vHIP innervation of mPFC neurons, and increased synaptic strength of vHIP inputs onto layer five pyramidal neurons as contributing factors of aberrant vHIP-mPFC signaling in Rett mice.

scholarly journals Long-Term MRI Cell Tracking after Intraventricular Delivery in a Patient with Global Cerebral Ischemia and Prospects for Magnetic Navigation of Stem Cells within the CSF

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e97631 ◽  
Author(s):  
Miroslaw Janowski ◽  
Piotr Walczak ◽  
Tomasz Kropiwnicki ◽  
Elzbieta Jurkiewicz ◽  
Krystyna Domanska-Janik ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebral Ischemia ◽  
Cell Tracking ◽  
Global Cerebral Ischemia ◽  
Magnetic Navigation
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