Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain

2007 ◽  
Vol 28 (4) ◽  
pp. 813-818 ◽  
Author(s):  
R.D. Carliss ◽  
A. Radovsky ◽  
C.P. Chengelis ◽  
T.P. O’Neill ◽  
D.L. Shuey
Keyword(s):  
Oral Administration ◽  
Rat Brain ◽  
Neuronal Vacuolation

scholarly journals The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress

2019 ◽  
Vol 302 ◽  
pp. 22-27 ◽  
Author(s):  
Oluyomi Stephen Adeyemi ◽  
Rhoda Ananu Uloko ◽  
Oluwakemi Josephine Awakan ◽  
Anne Adebukola Adeyanju ◽  
David Adeiza Otohinoyi
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Oral Administration ◽  
Rat Brain ◽  
Kynurenine Pathway

Sodium Nitrite Alone Protects the Brain Microsomal Ca2+-ATPase Against Potassium Cyanide-induced Neurotoxicity In Rats

1997 ◽  
Vol 17 (6) ◽  
pp. 543-546 ◽  
Author(s):  
O. O. Odunuga ◽  
G. A. Adenuga
Keyword(s):  
Oral Administration ◽  
Atpase Activity ◽  
Rat Brain ◽  
Sodium Nitrite ◽  
Specific Activity ◽  
Potassium Cyanide ◽  
Protective Role ◽  
Short Term ◽  
Significant Difference ◽  
The Brain

The effect of a short-term oral administration of potassium cyanide (KCN) (200 ppm in diet) with or without sodium nitrite (NaNO2) pretreatment on rat brain microsomal Ca2± ATPase was investigated. The specific activity value of the enzyme significantly decreased (p<0.05) by 50% compared with control and by 63% for KCN-treated rats compared with KCN-treated rats pretreated with NaNO2. There was no significant difference at the h=0.05 level between the values obtained for the control and KCN-treated rats pretreated with NaNO2. These results show both that feeding lowers brain microsomal Ca2+-ATPase activity and that NaNO2 has a protective role (antidote function) in that respect.

scholarly journals Curcumin Reduce Sodium Fluoride-Induced Oxidative Stress in Rat Brain

2018 ◽  
Vol 15 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Nagapuri Kiran Kumar ◽  
Mesram Nageshwar ◽  
Karnati Pratap Reddy
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Oral Administration ◽  
Rat Brain ◽  
Sodium Fluoride ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
The Brain

This study reports the ameliorative role of curcumin against sodium fluoride (NaF) induced oxidative stress in the brain of rats. The rats were divided into control, NaF (20 mg/kg), NaF+Curcumin (20mg/kg) and Curcumin (20mg/kg) groups respectively and treated at everyday interval for 60 consecutive days. Oxidative stress markers in the brain were measured at 60th day. NaF treatment significantly increased LPO content, but decreased the level of GSH and activities of SOD, GPx, and CAT the brain of rats in comparison to the control rats. Oral administration of curcumin to fluoride exposed rats significantly reversed the content of lipid peroxidation, as well as enhanced the level of GSH and SOD, GPx and CAT activities to normal compared to NaF exposed rats. Thus, curcumin showed the potential to prevent sodium fluoride induced oxidative damage in the brain of rats and curcumin may be useful agents against neurodegeneration in the brain.

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