scholarly journals Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models

2015 ◽  
Vol 36 (3) ◽  
pp. 1471-1482 ◽  
Author(s):  
Caroline Ménard ◽  
Rémi Quirion ◽  
Erika Vigneault ◽  
Sylvain Bouchard ◽  
Guylaine Ferland ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Rat Models ◽  
Postsynaptic Receptor ◽  
Vesicular Transporter ◽  
Aging Rat ◽  
Memory Status

scholarly journals The Effect of Saffron Aqueous Extract and Crocin on PTSD Rat Models: The Focus on Learning and Spatial Memory

2018 ◽  
Vol 26 (119) ◽  
pp. 34-42
Author(s):  
Sara Asalgoo ◽  
Gila Pirzad Jahromi ◽  
Boshra Hatef ◽  
Hedayat Sahraei ◽  
◽  
...  
Keyword(s):  
Spatial Memory ◽  
Aqueous Extract ◽  
Rat Models

scholarly journals Heme Oxygenase-1 Activity as a Correlate to Exercise-Mediated Amelioration of Cognitive Decline and Neuropathological Alterations in an Aging Rat Model of Dementia

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Andrea Kurucz ◽  
Mariann Bombicz ◽  
Rita Kiss ◽  
Dániel Priksz ◽  
Balázs Varga ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Spatial Memory ◽  
Heme Oxygenase ◽  
Rat Model ◽  
Aging Brain ◽  
Heme Oxygenase 1 ◽  
Free Access ◽  
Sedentary Control ◽  
Young Control ◽  
Aging Rat

Alzheimer’s disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed to examine the effect of voluntary exercise on spatial memory, imaging, and pathological abnormalities. Particular focus has been given to the role of heme oxygenase-1 (HO-1)—an important cellular cytoprotectant in preserving mental acuity—using an aging rat model of dementia. Male and female Wistar rats were segregated into six groups—namely, (i) aged sedentary (control) females (ASF, n=8); (ii) aged sedentary (control) males (ASM, n=8); (iii) aged running females (ARF, n=8); (iv) aged running males (ARM, n=8); (v) young control females (YCF, n=8); and (vi) young control males (YCM, n=8). Rats in the ARF and ARM groups had free access to a standardized inbuilt running wheel during the 3-month evaluation period. Spatial memory was investigated using the Morris Water Test, imaging and pathological alterations were assessed using positron emission tomography (PET) imaging and histopathological examinations (H&E, Congo red staining), respectively, and HO-1 enzyme activity assays were also conducted. The outcomes suggest that voluntary physical exercise mitigates impaired spatial memory and neuropathological changes exhibited by the aging sedentary group, via elevated HO-1 activity, contributing to the antioxidant capacity in the aging brain.

scholarly journals Memory-enhancing effects of goat milk in D-galactose-induced aging rat model

2020 ◽  
Vol 7 (1) ◽  
pp. 3563-3571
Author(s):  
Afifa Safdar ◽  
Khairunnuur Fairuz Azman ◽  
Rahimah Zakaria ◽  
Che Badariah Ab Aziz ◽  
Usman Rashid
Keyword(s):  
Spatial Memory ◽  
Rat Model ◽  
Memory Performance ◽  
Goat Milk ◽  
Treated Group ◽  
Control Group ◽  
Short Term ◽  
Significant Difference ◽  
Aging Rat

Introduction: Aging is a physiological process accompanied by cognitive decline, particularly in memory deterioration. D-galactose is a reducing monosaccharide which, if systemically exposed, causes accelerated senescence in several organs and is widely being used as an ideal agent to induce brain aging in animal models. Goat milk is a food of high nutritional value which has been demonstrated to possess strong antioxidant and anti-inflammatory properties. However, thus far, little is known of its possible effects on the brain, especially on memory during aging. The present study examined the efficiency of goat milk supplementation on memory performance in a D-galactose induced aging rat model. Methods: Fifty-two male Sprague Dawley rats were randomly divided into four groups: 1) control group, 2) goat milk treated group, 3) D-galactose treated group, and 4) goat milk plus D-galactose treated group. D-galactose (120 mg/kg subcutaneously) and/or goat milk (1 g/kg orally) were administered continuously for six weeks, preceded and followed by novel object recognition and T-maze tests. Results: Prior to goat milk and D-galactose administration, there was no significant difference (p>0.05) in memory performance among all groups. Six weeks of D-galactose administration significantly decreased (p<0.001) short-term, long-term and spatial memory performance. Goat milk supplementation in the D-galactose induced rats managed to protect against memory decline, as exhibited by significantly higher (p<0.0001) short-term, long-term and spatial memory performance of the D-galactose plus goat milk treated group, compared to the D-galactose treated group. Conclusion: In conclusion, goat milk possesses memoryenhancing effects and, hence. may be useful in protecting against age-related memory deficits.  

scholarly journals Effects of Sleep Deprivation in Young and Adult Rats: An Assessment of Memory and Anxiety

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Parvin Zareian ◽  
Mohsen Nategh
Keyword(s):  
Sleep Deprivation ◽  
Spatial Memory ◽  
Passive Avoidance ◽  
Age Groups ◽  
Avoidance Task ◽  
Adult Rats ◽  
Rem Sleep Deprivation ◽  
Sd Rats ◽  
Plus Maze ◽  
Memory Status

: As an important issue, sleep deprivation influences the cognition and mood of society. It both causes different effects on various individuals and age groups. However, the effects on various age groups are not well studied. The present study, which used a rat model of sleep deprivation, investigated the learning and memory status of sleep-deprived (SD) rats. Two groups of young and adult rats underwent 96 h of REM sleep deprivation by the inverted flowerpot method. Control groups were in the same condition but were could sleep normally. In behavioral groups, anxiety was assessed by an elevated plus-maze. Six weeks later, spatial memory was evaluated using the Morris water maze, and fear memory was assessed by passive avoidance learning. Based on the findings, SD increases anxiety in young rats. Regarding the spatial memory, young SD rats showed impairment in retrieval, but adult SD rats failed to learn the task as effectively as the controls. Memory retrieval in the passive avoidance task was impaired only in the adult SD rats. A different stage of memory affected by sleep deprivation in young and adult rats reflected varying mechanisms in these two age groups.

The Effect of Androgen Depletion and Replacement on the Epithelium of the Seminal Vesicle of the Aging Rat

1975 ◽  
Vol 33 ◽  
pp. 590-591
Author(s):  
Venita F. Allison
Keyword(s):  
Cell Proliferation ◽  
Seminal Vesicle ◽  
Male Rats ◽  
Target Cells ◽  
Cell Regeneration ◽  
Secretory Function ◽  
Electron Microscopic ◽  
Aging Rat ◽  
Microscopic Studies ◽  
Androgen Depletion

In 1930, Moore, Hughes and Gallager reported that after castration seminal vesicle epithelial cell atrophy occurred and that cell regeneration could be achieved with daily injections of testis extract. Electron microscopic studies have confirmed those observations and have shown that testosterone injections restore the epithelium of the seminal vesicle in adult castrated male rats. Studies concerned with the metabolism of androgens point out that dihydrotestosterone stimulates cell proliferation and that other metabolites of testosterone probably influence secretory function in certain target cells.Although the influence of androgens on adult seminal vesicle epithelial cytology is well documented, little is known of the effect of androgen depletion and replacement on those cells in aging animals. The present study is concerned with the effect of castration and testosterone injection on the epithelium of the seminal vesicle of aging rats.

Wechsler Memory Scale, Rivermead Behavioral Memory Test, and Everyday Memory Questionnaire in Healthy Adults and Alzheimer Patients

2002 ◽  
Vol 18 (1) ◽  
pp. 63-77 ◽  
Author(s):  
Anastasia Efklides ◽  
Efterpi Yiultsi ◽  
Theopisti Kangellidou ◽  
Fotini Kounti ◽  
Fotini Dina ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Semantic Memory ◽  
Memory Test ◽  
Healthy Adults ◽  
Gender Effects ◽  
Everyday Memory ◽  
Wechsler Memory Scale ◽  
Everyday Memory Questionnaire ◽  
Behavioral Memory ◽  
Memory Questionnaire

Summary: The Wechsler Memory Scale (WMS) is a laboratory-based memory test that has been criticized for its lack of ecological validity and for not testing long-term memory. A more recent memory test, which aims at testing everyday memory, is the Rivermead Behavioral Memory Test (RBMT); it tests prospective memory and other forms of memory not tapped by WMS. However, even this test does not capture all aspects of everyday memory problems often reported by adults. These problems are the object of the Everyday Memory Questionnaire (EMQ). This study aimed at identifying the relationships between these three memory tests. The differential effect of Alzheimer's disease (AD) on the above relationships was also studied. The sample consisted of 233 healthy adults (20 to 75+ years of age) and 39 AD patients (50 to 75 years of age). Confirmatory factor analysis revealed the following latent factors: Verbal Memory, Visual Reconstruction, Orientation, Message (action embedded in spatial context), Visual Recognition, Spatial Memory, New Learning/Association Forming, Prospective/Episodic Memory, and Metamemory. These first-order factors were further explained by two second-order factors: Semantic Memory and Coordination of Semantic and Visuo-Spatial Memory. This basic structure was preserved in the sample of AD patients, although AD patients performed less well on the WMS and the RBMT. Some interesting findings regarding semantic memory, face recognition, and metamemory in AD patients are also reported. Age, education, but no gender effects on memory performance were also detected.

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