scholarly journals Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease

2018 ◽  
Vol 72 ◽  
pp. 121-133 ◽  
Author(s):  
Rebecca Deering Brose ◽  
Elin Lehrmann ◽  
Yongqing Zhang ◽  
Roger H. Reeves ◽  
Kirby D. Smith ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Spatial Memory ◽  
Hippocampal Neurons ◽  
Model Of Alzheimer’S Disease

scholarly journals Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease

2018 ◽  
Vol 11 ◽  
Author(s):  
Silke Herzer ◽  
Cassidy Hagan ◽  
Johanna von Gerichten ◽  
Vanessa Dieterle ◽  
Bogdan Munteanu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Spatial Memory ◽  
Model Of Alzheimer’S Disease

scholarly journals miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Kai Zheng ◽  
Fan Hu ◽  
Yang Zhou ◽  
Juan Zhang ◽  
Jie Zheng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Signaling Pathway ◽  
Hippocampal Neurons ◽  
Therapeutic Strategy ◽  
Memory Deficits ◽  
Synaptic Activity ◽  
Memory Impairments ◽  
Model Of Alzheimer’S Disease

AbstractAberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer’s disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in a mouse model of AD. miR-135a-5p levels are significantly reduced in excitatory hippocampal neurons of AD model mice. This decrease is tau dependent and mediated by Foxd3. Inhibition of miR-135a-5p leads to synaptic disorder and memory impairments. Furthermore, excess Rock2 levels caused by loss of miR-135a-5p plays an important role in the synaptic disorder of AD via phosphorylation of Ser726 on adducin 1 (Add1). Blocking the phosphorylation of Ser726 on Add1 with a membrane-permeable peptide effectively rescues the memory impairments in AD mice. Taken together, these findings demonstrate that synaptic-related miR-135a-5p mediates synaptic/memory deficits in AD via the Rock2/Add1 signaling pathway, illuminating a potential therapeutic strategy for AD.

scholarly journals HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease

Aging Cell ◽  
2017 ◽  
Vol 16 (5) ◽  
pp. 1073-1082 ◽  
Author(s):  
Xiaolei Zhu ◽  
Sulei Wang ◽  
Linjie Yu ◽  
Jiali Jin ◽  
Xing Ye ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Spatial Memory ◽  
Model Of Alzheimer’S Disease
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