scholarly journals Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation

Neuron ◽  
2020 ◽  
Vol 107 (3) ◽  
pp. 509-521.e7 ◽  
Author(s):  
David Vandael ◽  
Carolina Borges-Merjane ◽  
Xiaomin Zhang ◽  
Peter Jonas
Keyword(s):  
Mossy Fiber ◽  
Activity Patterns ◽  
Short Term ◽  
Natural Activity ◽  
Short Term Plasticity ◽  
Vesicle Pool

scholarly journals Short-Term Plasticity of Kainate Receptor-Mediated EPSCs Induced by NMDA Receptors at Hippocampal Mossy Fiber Synapses

2007 ◽  
Vol 27 (15) ◽  
pp. 3987-3993 ◽  
Author(s):  
N. Rebola ◽  
S. Sachidhanandam ◽  
D. Perrais ◽  
R. A. Cunha ◽  
C. Mulle
Keyword(s):  
Nmda Receptors ◽  
Mossy Fiber ◽  
Kainate Receptor ◽  
Short Term ◽  
Short Term Plasticity

scholarly journals Retrograde suppression of post-tetanic potentiation at the mossy fiber-CA3 pyramidal cell synapse

2020 ◽  
Author(s):  
Sachin Makani ◽  
Stefano Lutzu ◽  
Pablo J. Lituma ◽  
David L. Hunt ◽  
Pablo E. Castillo
Keyword(s):  
Metabotropic Glutamate Receptors ◽  
Granule Cells ◽  
Mossy Fiber ◽  
Hippocampal Slices ◽  
Dependent Manner ◽  
Short Term ◽  
Short Term Plasticity ◽  
Dentate Granule Cells ◽  
Post Tetanic Potentiation ◽  
Frequency Facilitation

ABSTRACTIn the hippocampus, the excitatory synapse between dentate granule cell axons – or mossy fibers (MF) – and CA3 pyramidal cells (MF-CA3) expresses robust forms of short-term plasticity, such as frequency facilitation and post-tetanic potentiation (PTP). These forms of plasticity are due to increases in neurotransmitter release, and can be engaged when dentate granule cells fire in bursts (e.g. during exploratory behaviors) and bring CA3 pyramidal neurons above threshold. While frequency facilitation at this synapse is limited by endogenous activation of presynaptic metabotropic glutamate receptors, whether MF-PTP can be regulated in an activity-dependent manner is unknown. Here, using physiologically relevant patterns of mossy fiber stimulation in acute mouse hippocampal slices, we found that disrupting postsynaptic Ca2+ dynamics increases MF-PTP, strongly suggesting a form of Ca2+-dependent retrograde suppression of this form of plasticity. PTP suppression requires a few seconds of MF bursting activity and Ca2+ release from internal stores. Our findings raise the possibility that the powerful MF-CA3 synapse can negatively regulate its own strength not only during PTP-inducing activity typical of normal exploratory behaviors, but also during epileptic activity.SIGNIFICANCE STATEMENTThe powerful mossy fiber-CA3 synapse exhibits strong forms of plasticity that are engaged during location-specific exploration, when dentate granule cells fire in bursts. While this synapse is well-known for its presynaptically-expressed LTP and LTD, much less is known about the robust changes that occur on a shorter time scale. How such short-term plasticity is regulated, in particular, remains poorly understood. Unexpectedly, an in vivo-like pattern of presynaptic activity induced robust post-tetanic potentiation (PTP) only when the postsynaptic cell was loaded with a high concentration of Ca2+ buffer, indicating a form of Ca2+–dependent retrograde suppression of PTP. Such suppression may have profound implications for how environmental cues are encoded into neural assemblies, and for limiting network hyperexcitability during seizures.

scholarly journals Target-Cell Specificity of Kainate Autoreceptor and Ca2+-Store-Dependent Short-Term Plasticity at Hippocampal Mossy Fiber Synapses

2008 ◽  
Vol 28 (49) ◽  
pp. 13139-13149 ◽  
Author(s):  
R. Scott ◽  
T. Lalic ◽  
D. M. Kullmann ◽  
M. Capogna ◽  
D. A. Rusakov
Keyword(s):  
Target Cell ◽  
Mossy Fiber ◽  
Short Term ◽  
Short Term Plasticity ◽  
Cell Specificity

scholarly journals Nonlinear transient amplification in recurrent neural networks with short-term plasticity

2021 ◽  
Author(s):  
Yue Kris Wu ◽  
Friedemann Zenke
Keyword(s):  
Specific Activity ◽  
Feedback Inhibition ◽  
Activity Patterns ◽  
Network Models ◽  
Critical Threshold ◽  
Short Term ◽  
Short Term Plasticity ◽  
Nonlinear Transient ◽  
Rapid Amplification ◽  
Nonlinear Operation

To rapidly process information, neural circuits have to amplify specific activity patterns transiently. How the brain performs this nonlinear operation remains elusive. Hebbian assemblies are one possibility whereby symmetric excitatory connections boost neuronal activity. However, such Hebbian amplification is often associated with dynamical slowing of network dynamics, non-transient attractor states, and pathological run-away activity. Feedback inhibition can alleviate these effects but typically linearizes responses and reduces amplification gain. At the same time, other alternative mechanisms rely on asymmetric connectivity, in conflict with the Hebbian doctrine. Here we propose nonlinear transient amplification (NTA), a plausible circuit mechanism that reconciles symmetric connectivity with rapid amplification while avoiding the above issues. NTA has two distinct temporal phases. Initially, positive feedback excitation selectively amplifies inputs that exceed a critical threshold. Subsequently, short-term plasticity quenches the run-away dynamics into an inhibition-stabilized network state. By characterizing NTA in supralinear network models, we establish that the resulting onset transients are stimulus selective and well-suited for speedy information processing. Further, we find that excitatory-inhibitory co-tuning widens the parameter regime in which NTA is possible. In summary, NTA provides a parsimonious explanation for how excitatory-inhibitory co-tuning and short-term plasticity collaborate in recurrent networks to achieve transient amplification.

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