Nestin expression in Müller glial cells in postnatal rat retina and its upregulation following optic nerve transection

Neuroscience ◽  
2006 ◽  
Vol 143 (1) ◽  
pp. 117-127 ◽  
Author(s):  
L.P. Xue ◽  
J. Lu ◽  
Q. Cao ◽  
C. Kaur ◽  
E.-A. Ling
Keyword(s):  
Optic Nerve ◽  
Glial Cells ◽  
Nerve Transection ◽  
Nestin Expression ◽  
Rat Retina ◽  
Müller Glial Cells ◽  
Optic Nerve Transection

scholarly journals Transcriptome profiling of the rat retina after optic nerve transection

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Masayuki Yasuda ◽  
Yuji Tanaka ◽  
Kazuko Omodaka ◽  
Koji M. Nishiguchi ◽  
Orie Nakamura ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Transcriptome Profiling ◽  
Nerve Transection ◽  
Rat Retina ◽  
Optic Nerve Transection

scholarly journals Nestin, A New Marker, Expressed in Müller Cells Following Retinal Injury

2010 ◽  
Vol 37 (5) ◽  
pp. 643-649 ◽  
Author(s):  
Liping Xue ◽  
Peng Ding ◽  
Libo Xiao ◽  
Min Hu ◽  
Zhulin Hu
Keyword(s):  
Optic Nerve ◽  
Structural Integrity ◽  
Müller Cells ◽  
Muller Cells ◽  
Nerve Transection ◽  
Nestin Expression ◽  
Experimental Glaucoma ◽  
Retinal Injury ◽  
Optic Nerve Transection ◽  
Immunofluorescence Labeling

Purpose:To investigate whether nestin would be a useful marker for retinal injury and also to ascertain a better understanding of the roles of Müller cells in the injured retina by the use of damaged rat retina.Methods:A total of 33 adult female Wistar rats were used in this study. Three were used as controls and the remaining as retinal injury modes (6 for hypoxia; 15 for experimental glaucoma and 9 for optic nerve transection). Double immunofluorescence labeling was carried out between nestin and glutamine synthetase (GS), and between glial fibrillary acidic protein (GFAP) and GS antisera in normal and pathological retinae.Results:The results showed that there were no nestin nor GFAP staining in mature Müller cells of the normal retina. A major finding was that nestin expression was induced in Müller cells subjected to hypoxia, glaucoma and optic nerve transection.Conclusions:These results suggest that nestin as well as GFAP (even more sensitive than GFAP) are useful and reliable biomarkers for retinal damage. The more intense expression of nestin, GFAP and GS in the end-feet of Müller cells suggest that they may help to maintain the retinal structural integrity and to enhance functional recovery in various retinal diseases.

Upregulation of ciliary neurotrophic factor in reactive Müller cells in the rat retina following optic nerve transection

2000 ◽  
Vol 868 (2) ◽  
pp. 358-362 ◽  
Author(s):  
Myung-Hoon Chun ◽  
Won-Kyu Ju ◽  
Keun-Young Kim ◽  
Mun-Yong Lee ◽  
Hans-Dieter Hofmann ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Neurotrophic Factor ◽  
Müller Cells ◽  
Ciliary Neurotrophic Factor ◽  
Muller Cells ◽  
Nerve Transection ◽  
Rat Retina ◽  
Optic Nerve Transection
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