Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: An involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3β intracellular signaling pathway

Neuroscience ◽  
2007 ◽  
Vol 145 (2) ◽  
pp. 592-604 ◽  
Author(s):  
M. Kajta ◽  
H. Domin ◽  
G. Grynkiewicz ◽  
W. Lason
Keyword(s):  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Cell Cultures ◽  
Intracellular Signaling ◽  
Glycogen Synthase ◽  
Neuronal Cell ◽  
Glycogen Synthase Kinase 3Β ◽  
Intracellular Signaling Pathway ◽  
Neuronal Cell Cultures ◽  
Aryl Hydrocarbon

scholarly journals Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types—Tumour Microenvironment and Metabolism

2020 ◽  
Vol 22 (1) ◽  
pp. 141
Author(s):  
George Anderson
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Glycogen Synthase ◽  
Tumour Progression ◽  
Cell Types ◽  
Tumour Microenvironment ◽  
Future Research ◽  
Acetyl Coa ◽  
Dynamic Interactions ◽  
Aryl Hydrocarbon ◽  
Metabolic Interactions

This article reviews the dynamic interactions of the tumour microenvironment, highlighting the roles of acetyl-CoA and melatonergic pathway regulation in determining the interactions between oxidative phosphorylation (OXPHOS) and glycolysis across the array of cells forming the tumour microenvironment. Many of the factors associated with tumour progression and immune resistance, such as yin yang (YY)1 and glycogen synthase kinase (GSK)3β, regulate acetyl-CoA and the melatonergic pathway, thereby having significant impacts on the dynamic interactions of the different types of cells present in the tumour microenvironment. The association of the aryl hydrocarbon receptor (AhR) with immune suppression in the tumour microenvironment may be mediated by the AhR-induced cytochrome P450 (CYP)1b1-driven ‘backward’ conversion of melatonin to its immediate precursor N-acetylserotonin (NAS). NAS within tumours and released from tumour microenvironment cells activates the brain-derived neurotrophic factor (BDNF) receptor, TrkB, thereby increasing the survival and proliferation of cancer stem-like cells. Acetyl-CoA is a crucial co-substrate for initiation of the melatonergic pathway, as well as co-ordinating the interactions of OXPHOS and glycolysis in all cells of the tumour microenvironment. This provides a model of the tumour microenvironment that emphasises the roles of acetyl-CoA and the melatonergic pathway in shaping the dynamic intercellular metabolic interactions of the various cells within the tumour microenvironment. The potentiation of YY1 and GSK3β by O-GlcNAcylation will drive changes in metabolism in tumours and tumour microenvironment cells in association with their regulation of the melatonergic pathway. The emphasis on metabolic interactions across cell types in the tumour microenvironment provides novel future research and treatment directions.

scholarly journals Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

2016 ◽  
Vol 437 ◽  
pp. 190-200 ◽  
Author(s):  
Ping Gong ◽  
Zeynep Madak-Erdogan ◽  
Jodi A. Flaws ◽  
David J. Shapiro ◽  
John A. Katzenellenbogen ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Estrogen Receptor Α ◽  
Target Cells ◽  
Aryl Hydrocarbon

scholarly journals Microfluidic hydrogel layers with multiple gradients to stimulate and perfuse three-dimensional neuronal cell cultures

2009 ◽  
Vol 1 (1) ◽  
pp. 369-372 ◽  
Author(s):  
Anja Kunze ◽  
Arnaud Bertsch ◽  
Michele Giugliano ◽  
Philippe Renaud
Keyword(s):  
Cell Cultures ◽  
Three Dimensional ◽  
Neuronal Cell ◽  
Neuronal Cell Cultures

Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor

2013 ◽  
Vol 29 (10) ◽  
pp. 1201-1216 ◽  
Author(s):  
Svjetlana Medjakovic ◽  
Alfred Zoechling ◽  
Petra Gerster ◽  
Margarita M. Ivanova ◽  
Yun Teng ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon
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