Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives

AbstractRisk-taking behavior and impulsivity are core features of bipolar disorder. Whether they are part of the inherited aspect of the illness is not clear. We aimed to evaluate risk-taking behavior as a potential endophenotype for bipolar disorders, and its relationship with impulsivity and illness features. The Balloon Analogue Risk Task (BART) and Barratt Impulsiveness Scale-11 (BIS-11) were used to assess risk-taking behavior and impulsivity respectively in 30 euthymic bipolar I patients (BD), their 25 asymptomatic first-degree relatives (BD-R), and 30 healthy controls (HC). The primary BART outcome measure was the behavioral adjustment score (number of pumps after trials where the balloon did not pop minus the number of pumps after trials where the balloon popped). BD (p< .001) and BD-R (p= .001) had similar and significantly lower adjustment scores than HC. Only BD scored significantly higher on BIS-11 total (p= .01) and motor (p= .04) subscales than HC. Neither the BART, nor impulsivity scores associated with illness features. A limitation of this study is medicated patients and a heterogeneous BD-R were included. Riskiness may be a candidate endophenotype for bipolar disorder as it appears independently from illness features, presents similarly in BD and BD-R groups and differs from impulsivity. (JINS, 2013,19, 1–9)

Download Full-text

Dexamethasone suppression test in early- and late-stage patients with bipolar disorder type I and first-degree relatives: a preliminary analysis

Pharmacopsychiatry ◽

10.1055/s-0033-1353270 ◽

2013 ◽

Vol 46 (06) ◽

Author(s):

GR Fries ◽

T Rein ◽

M Kauer-Sant'Anna

Keyword(s):

Bipolar Disorder ◽

Late Stage ◽

Preliminary Analysis ◽

Dexamethasone Suppression Test ◽

Type I ◽

First Degree Relatives ◽

Suppression Test ◽

Disorder Type ◽

Dexamethasone Suppression

Download Full-text

Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function

Acta Psychiatrica Scandinavica ◽

10.1111/acps.12922 ◽

2018 ◽

Vol 138 (4) ◽

pp. 325-335 ◽

Cited By ~ 14

Author(s):

C. Abé ◽

S. Rolstad ◽

P. Petrovic ◽

C.-J. Ekman ◽

T. Sparding ◽

...

Keyword(s):

Bipolar Disorder ◽

Executive Function ◽

Cortical Thickness ◽

Type I ◽

Disorder Type

Download Full-text

Neurocognition in Unaffected First-Degree Relatives of Patients With Bipolar Disorder Type I From India

SAGE Open ◽

10.1177/2158244011436351 ◽

2012 ◽

Vol 2 (1) ◽

pp. 215824401143635 ◽

Cited By ~ 4

Author(s):

Raman Deep Pattanayak ◽

Rajesh Sagar ◽

Manju Mehta

Keyword(s):

Bipolar Disorder ◽

Verbal Memory ◽

Formal Education ◽

Type I ◽

Trail Making Test ◽

Healthy Controls ◽

Cross Sectional ◽

First Degree Relatives ◽

Trail Making ◽

Disorder Type

The study aims to evaluate the neuropsychological functions of unaffected first-degree relatives of patients with bipolar disorder Type I (BD-I) in comparison with healthy controls. The method was a cross-sectional assessment of 20 first-degree relatives of patients with BD-I and 20 healthy controls. Inclusion criteria for all participants included age between 18 and 55 years, ≥5 years of formal education, right-handedness as per Edinburgh handedness inventory, absence of color blindness as per Ishihara’s isochromatic charts, and a score of >24 on Hindi mental state examination. None of the participants had a current or lifetime diagnosis of a mental disorder on Structured Clinical Interview for DSM-IV, Clinician Version. Neuropsychological assessment was conducted with Trail Making Test A and B, Stroop color and word test, N-Back Verbal Memory Test, and Post Graduate Institute (PGI) Memory Scale. Both the groups were comparable in age, gender distribution, and education. The unaffected first-degree relatives performed poorly on Trail Making Test B and (B-A), indicating a poor cognitive flexibility and set-shifting. The relative group also performed poorly on Mental Balance subtest of PGI Memory Scale. The unaffected first-degree relatives of patients with BD display certain impairments in dorsal prefrontal executive functions which can serve as vulnerability markers for BD.

Download Full-text

Lack of confirmation of thyroid endophenotype in Bipolar Disorder Type I and their first-degree relatives

Psychoneuroendocrinology ◽

10.1016/j.psyneuen.2014.09.032 ◽

2015 ◽

Vol 51 ◽

pp. 351-364 ◽

Cited By ~ 6

Author(s):

Jesus Cobo ◽

Olga Giménez-Palop ◽

Ester Patró ◽

Mireia Pérez ◽

Francisco Bleda ◽

...

Keyword(s):

Bipolar Disorder ◽

Type I ◽

First Degree Relatives ◽

Disorder Type

Download Full-text

Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Journal of Affective Disorders ◽

10.1016/j.jad.2014.08.016 ◽

2014 ◽

Vol 169 ◽

pp. 118-127 ◽

Cited By ~ 48

Author(s):

Jerome J. Maller ◽

Prasanthan Thaveenthiran ◽

Richard H. Thomson ◽

Susan McQueen ◽

Paul B. Fitzgerald

Keyword(s):

Bipolar Disorder ◽

White Matter ◽

Cortical Thickness ◽

White Matter Integrity ◽

Type I ◽

Disorder Type

Download Full-text

Cortical thickness, cortical surface area and subcortical volumes in schizophrenia and bipolar disorder patients with cannabis use

10.26226/morressier.5971be84d462b80290b52671 ◽

2017 ◽

Author(s):

Cecilie Bhandari Hartberg

Keyword(s):

Bipolar Disorder ◽

Surface Area ◽

Cortical Thickness ◽

Cannabis Use ◽

Cortical Surface ◽

Cortical Surface Area ◽

Subcortical Volumes

Download Full-text

Cytokine Polymorphisms in the Pathophysiology of Mood Disorders

CNS Spectrums ◽

10.1017/s1092852900020393 ◽

2009 ◽

Vol 14 (8) ◽

pp. 419-425 ◽

Cited By ~ 52

Author(s):

Mario Clerici ◽

Beatrice Arosio ◽

Emanuela Mundo ◽

Elisabetta Cattaneo ◽

Sara Pozzoli ◽

...

Keyword(s):

Bipolar Disorder ◽

Mood Disorders ◽

Lower Percentage ◽

Genetic Profile ◽

Type I ◽

Genotype Distribution ◽

Bipolar Ii ◽

Tnf Α ◽

Ifn Γ ◽

Disorder Type

ABSTRACTIntroduction: An increasing amount of data suggests that dysregulation of the immune system, including the cytokine network, is associated with the etiology and pathophysiology of mood disorders. Genes encoding cytokines are highly polymorphic and single nucleotide polymorphisms, associated with increased or reduced cytokine production, have been described. The aim of this study was to define the genetic immunologic scenario associated with major depressive disorder (MDD) and bipolar disorder.Methods: Eighty-four Italian outpatients affected by bipolar disorder type I, bipolar disorder type II, or MDD, and 363 healthy controls were enrolled into the study. We analyzed allele and genotype distribution of −308 (G/A) tumor necrosis factor-α (TNF-α), +874 (T/A) interferon-γ (IFN-γ), -174 (G/C) interleukin (IL)-6, and −1082 (G/A) IL-10 promoter polymorphisms by Polymerase Chain Reaction Sequence Specific Primers technique.Results: We observed different genotype and allele distributions of TNF-α, IFN-γ, and IL-10 polymorphisms in the three groups of patients analyzed. In particular, bipolar II patients were characterized by an absence of adenine (A) high producer allele of TNF-α (P<.001) and a lower percentage of TT high producer genotype of IFN-γ (P <.001); bipolar I individuals showed reduced percentage of AA low producer genotype of IL-10 (P<.001). Both bipolar I and bipolar II patients not carrying guanine (G) high producer IL-6 allele showed a lower mean age at onset (P=.048).Conclusion: These data support the existence of a genetic profile related to pro-inflammatory cytokines in patients affected by mood disorders. The differences observed across the three clinical phenotypes suggest the presence of different pathogenetic mechanisms involved in the susceptibility of phenotypically different mood disorders.

Download Full-text